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Fermentation, volume 9, issue 4, pages 337

A Study of the Metabolic Profiles of Penicillium dimorphosporum KMM 4689 Which Led to Its Re-Identification as Penicillium hispanicum

Nesterenko Liliana E. ^{1, 2}

Popov Nikita S ¹

Zhuravleva Olesya I ^{1, 2}

Kirichuk Natalya N ¹

Chausova Victoria ¹

Krasnov Kirill ³

Pivkin Mikhail V ¹

YURCHENKO EKATERINA Y. ¹

Исаева М. А. ¹

Yurchenko Anton N ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch of Russian Academy of Science, Prospect 100-Letiya Vladivostoka, 159, 690022 Vladivostok, Russia |

Institute of High Technologies and Advanced Materials, Far Eastern Federal University, 10 Ajax Bay, Russky Island, 690922 Vladivostok, Russia |

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya ul., 3, 142290 Pushchino, Russia |

Publication type: Journal Article

Publication date: 2023-03-28

Multidisciplinary Digital Publishing Institute (MDPI)

Journal: Fermentation

Quartile SCImago

Quartile WOS

Impact factor: 3.7

ISSN: 23115637

DOI: 10.3390/fermentation9040337

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Plant Science

Food Science

Biochemistry, Genetics and Molecular Biology (miscellaneous)

Abstract

Changes in cultivation conditions, in particular salinity and temperature, affect the production of secondary fungal metabolites. In this work, the extracts of fungus previously described as Penicillium dimorphosporum cultivated in various salinity and temperature conditions were investigated using HPLC UV/MS techniques, and their DPPH radical scavenging and cytotoxicity activities against human prostate cancer PC-3 cells and rat cardiomyocytes H9c2 were tested. In total, 25 compounds, including 13 desoxyisoaustamide-related alkaloids and eight anthraquinones, were identified in the studied extracts and their relative amounts were estimated. The production of known neuroprotective alkaloids 5, 6 and other brevianamide alkaloids was increased in hypersaline and high-temperature conditions, and this may be an adaptation to extreme conditions. On the other hand, hyposalinity stress may induce the synthesis of unidentified antioxidants with low cytotoxicity that could be very interesting for future investigation. The study of secondary metabolites of the strain KMM 4689 showed that although brevianamide-related alkaloids and anthraquinone pigments are widely distributed in various fungi, these metabolites have not been described for P. dimorphosporum and related species. For this reason, the strain KMM 4689 was re-sequenced using the β-tubulin gene and ITS regions as molecular markers and further identified as P. hispanicum.

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Nesterenko L. E. et al. A Study of the Metabolic Profiles of Penicillium dimorphosporum KMM 4689 Which Led to Its Re-Identification as Penicillium hispanicum // Fermentation. 2023. Vol. 9. No. 4. p. 337.

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Nesterenko L. E., Popov N. S., Zhuravleva O. I., Kirichuk N. N., Chausova V., Krasnov K., Pivkin M. V., YURCHENKO E. Y., Исаева М. А., Yurchenko A. N. A Study of the Metabolic Profiles of Penicillium dimorphosporum KMM 4689 Which Led to Its Re-Identification as Penicillium hispanicum // Fermentation. 2023. Vol. 9. No. 4. p. 337.

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TY - JOUR

DO - 10.3390/fermentation9040337

UR - https://doi.org/10.3390%2Ffermentation9040337

TI - A Study of the Metabolic Profiles of Penicillium dimorphosporum KMM 4689 Which Led to Its Re-Identification as Penicillium hispanicum

T2 - Fermentation

AU - Nesterenko, Liliana E.

AU - Popov, Nikita S

AU - Zhuravleva, Olesya I

AU - Kirichuk, Natalya N

AU - Chausova, Victoria

AU - Krasnov, Kirill

AU - Pivkin, Mikhail V

AU - YURCHENKO, EKATERINA Y.

AU - Исаева, М. А.

AU - Yurchenko, Anton N

PY - 2023

DA - 2023/03/28 00:00:00

PB - Multidisciplinary Digital Publishing Institute (MDPI)

SP - 337

IS - 4

VL - 9

SN - 2311-5637

ER -

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@article{2023_Nesterenko,

author = {Liliana E. Nesterenko and Nikita S Popov and Olesya I Zhuravleva and Natalya N Kirichuk and Victoria Chausova and Kirill Krasnov and Mikhail V Pivkin and EKATERINA Y. YURCHENKO and М. А. Исаева and Anton N Yurchenko},

title = {A Study of the Metabolic Profiles of Penicillium dimorphosporum KMM 4689 Which Led to Its Re-Identification as Penicillium hispanicum},

journal = {Fermentation},

year = {2023},

volume = {9},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

month = {mar},

url = {https://doi.org/10.3390%2Ffermentation9040337},

number = {4},

pages = {337},

doi = {10.3390/fermentation9040337}

}

MLA

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Nesterenko, Liliana E., et al. “A Study of the Metabolic Profiles of Penicillium dimorphosporum KMM 4689 Which Led to Its Re-Identification as Penicillium hispanicum.” Fermentation, vol. 9, no. 4, Mar. 2023, p. 337. https://doi.org/10.3390%2Ffermentation9040337.

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Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

Journal

Fermentation

Quartile SCImago

Quartile WOS

Impact factor

3.7

ISSN

23115637 (Electronic)

Labs

Laboratory of biologically active compounds

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