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Open access
Future Pharmacology, volume 4, issue 3, pages 590-625

Cannabinoids from C. sativa L.: Systematic Review on Potential Pharmacological Effects against Infectious Diseases Downstream and Multidrug-Resistant Pathogens

Adriana Ribeiro 1
Rahaf Alsayyed 2
Daniele Oliveira 3, 4
Rui Loureiro 1
Helena Cabral-Marques 1
2
 
Independent Researcher, 1100-000 Lisboa, Portugal
3
 
Centro Hospitalar de Setúbal, 2910-549 Setúbal, Portugal
4
 
Hospital da Luz Setúbal, 2900-722 Setúbal, Portugal
Publication typeJournal Article
Publication date2024-09-09
SJR
CiteScore
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ISSN26739879
Abstract

Cannabis sativa L. has garnered attention as a potential source for new antimicrobial agents, particularly due to the increased prevalence of microbial resistance to conventional antimicrobials and the emergence of multidrug-resistant pathogens. This review, conducted according to the PRISMA 2020 statement, systematically analyzed the antimicrobial properties of C. sativa extracts and cannabinoids against various bacteria, fungi, viruses, and parasites. Data were collected from the scientific literature (102 papers) and clinical trials (5 studies) from 2014 to June 2024. Findings revealed that cannabinoids, especially CBD, demonstrate significant antimicrobial activity against Gram-positive bacteria like MRSA, Gram-negative bacteria such as Pseudomonas aeruginosa, various Candida species, SARS-CoV-2, and HIV. Additionally, CBD showed efficacy against parasitic infections like Echinococcus granulosus and Leishmania species. These results suggest that cannabinoids may represent a new class of antimicrobial agents with unique and diverse mechanisms of action, potentially effective in broad-spectrum therapies. This study highlights the urgent need for further research and standardized clinical trials to validate these findings and to develop cannabinoid-based treatments. The antimicrobial properties of C. sativa align with WHO priorities and support global health initiatives, offering promising avenues for addressing antimicrobial resistance and improving public health outcomes.

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GOST Copy
Ribeiro A. et al. Cannabinoids from C. sativa L.: Systematic Review on Potential Pharmacological Effects against Infectious Diseases Downstream and Multidrug-Resistant Pathogens // Future Pharmacology. 2024. Vol. 4. No. 3. pp. 590-625.
GOST all authors (up to 50) Copy
Ribeiro A., Alsayyed R., Oliveira D., Loureiro R., Cabral-Marques H. Cannabinoids from C. sativa L.: Systematic Review on Potential Pharmacological Effects against Infectious Diseases Downstream and Multidrug-Resistant Pathogens // Future Pharmacology. 2024. Vol. 4. No. 3. pp. 590-625.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3390/futurepharmacol4030033
UR - https://www.mdpi.com/2673-9879/4/3/33
TI - Cannabinoids from C. sativa L.: Systematic Review on Potential Pharmacological Effects against Infectious Diseases Downstream and Multidrug-Resistant Pathogens
T2 - Future Pharmacology
AU - Ribeiro, Adriana
AU - Alsayyed, Rahaf
AU - Oliveira, Daniele
AU - Loureiro, Rui
AU - Cabral-Marques, Helena
PY - 2024
DA - 2024/09/09
PB - MDPI
SP - 590-625
IS - 3
VL - 4
SN - 2673-9879
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2024_Ribeiro,
author = {Adriana Ribeiro and Rahaf Alsayyed and Daniele Oliveira and Rui Loureiro and Helena Cabral-Marques},
title = {Cannabinoids from C. sativa L.: Systematic Review on Potential Pharmacological Effects against Infectious Diseases Downstream and Multidrug-Resistant Pathogens},
journal = {Future Pharmacology},
year = {2024},
volume = {4},
publisher = {MDPI},
month = {sep},
url = {https://www.mdpi.com/2673-9879/4/3/33},
number = {3},
pages = {590--625},
doi = {10.3390/futurepharmacol4030033}
}
MLA
Cite this
MLA Copy
Ribeiro, Adriana, et al. “Cannabinoids from C. sativa L.: Systematic Review on Potential Pharmacological Effects against Infectious Diseases Downstream and Multidrug-Resistant Pathogens.” Future Pharmacology, vol. 4, no. 3, Sep. 2024, pp. 590-625. https://www.mdpi.com/2673-9879/4/3/33.
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