Open Access
International Journal of Molecular Sciences, volume 21, issue 18, pages 6961
Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers
Kashapov Ruslan
1
,
Gabdrakhmanov Dinar
1
,
Kuznetsov Denis
1
,
Pavlov Rais
1
,
Petrov Konstantin
1
,
Zakharova Lucia
1
,
Sinyashin Oleg
1
Publication type: Journal Article
Publication date: 2020-09-22
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
PubMed ID:
32971917
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
This review focuses on synthetic and natural amphiphilic systems prepared from straight-chain and macrocyclic compounds capable of self-assembly with the formation of nanoscale aggregates of different morphology and their application as drug carriers. Since numerous biological species (lipid membrane, bacterial cell wall, mucous membrane, corneal epithelium, biopolymers, e.g., proteins, nucleic acids) bear negatively charged fragments, much attention is paid to cationic carriers providing high affinity for encapsulated drugs to targeted cells. First part of the review is devoted to self-assembling and functional properties of surfactant systems, with special attention focusing on cationic amphiphiles, including those bearing natural or cleavable fragments. Further, lipid formulations, especially liposomes, are discussed in terms of their fabrication and application for intracellular drug delivery. This section highlights several features of these carriers, including noncovalent modification of lipid formulations by cationic surfactants, pH-responsive properties, endosomal escape, etc. Third part of the review deals with nanocarriers based on macrocyclic compounds, with such important characteristics as mucoadhesive properties emphasized. In this section, different combinations of cyclodextrin platform conjugated with polymers is considered as drug delivery systems with synergetic effect that improves solubility, targeting and biocompatibility of formulations.
Citations by journals
Citations by publishers
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5
10
15
20
25
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
21 publications, 36.21%
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Elsevier
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Elsevier
13 publications, 22.41%
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Pleiades Publishing
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Pleiades Publishing
6 publications, 10.34%
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Springer Nature
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Springer Nature
5 publications, 8.62%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
2 publications, 3.45%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
2 publications, 3.45%
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Bentham Science
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Bentham Science
2 publications, 3.45%
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Wiley
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Wiley
2 publications, 3.45%
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Thomas Telford
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Thomas Telford
1 publication, 1.72%
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IOP Publishing
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IOP Publishing
1 publication, 1.72%
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Taylor & Francis
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Taylor & Francis
1 publication, 1.72%
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5
10
15
20
25
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Kashapov R. et al. Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers // International Journal of Molecular Sciences. 2020. Vol. 21. No. 18. p. 6961.
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Kashapov R., Gaynanova G., Gabdrakhmanov D., Kuznetsov D., Pavlov R., Petrov K., Zakharova L., Sinyashin O. Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers // International Journal of Molecular Sciences. 2020. Vol. 21. No. 18. p. 6961.
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TY - JOUR
DO - 10.3390/ijms21186961
UR - https://doi.org/10.3390%2Fijms21186961
TI - Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers
T2 - International Journal of Molecular Sciences
AU - Kashapov, Ruslan
AU - Kuznetsov, Denis
AU - Pavlov, Rais
AU - Petrov, Konstantin
AU - Zakharova, Lucia
AU - Sinyashin, Oleg
AU - Gaynanova, Gulnara
AU - Gabdrakhmanov, Dinar
PY - 2020
DA - 2020/09/22 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 6961
IS - 18
VL - 21
PMID - 32971917
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2020_Kashapov,
author = {Ruslan Kashapov and Denis Kuznetsov and Rais Pavlov and Konstantin Petrov and Lucia Zakharova and Oleg Sinyashin and Gulnara Gaynanova and Dinar Gabdrakhmanov},
title = {Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers},
journal = {International Journal of Molecular Sciences},
year = {2020},
volume = {21},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {sep},
url = {https://doi.org/10.3390%2Fijms21186961},
number = {18},
pages = {6961},
doi = {10.3390/ijms21186961}
}
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Kashapov, Ruslan, et al. “Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers.” International Journal of Molecular Sciences, vol. 21, no. 18, Sep. 2020, p. 6961. https://doi.org/10.3390%2Fijms21186961.