Open Access
The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification
Carrow Wells
1
,
Hassan Al-Ali
2, 3
,
David M Andrews
4
,
Alison D Axtman
1
,
Ivan Dikic
5, 6, 7
,
Daniel Ebner
8
,
Peter Ettmayer
9
,
Christian Fischer
10
,
Mathias Frederiksen
11
,
Robert E Futrell
1
,
Nathanael S. Gray
12, 13
,
Stephanie B Hatch
14
,
S. Knapp
6, 15, 16
,
Ulrich Lücking
17
,
Michael Michaelides
18
,
Caitlin E Mills
19
,
Susanne Müller
6, 15, 16
,
Dafydd Owen
20
,
Alfredo Picado
1
,
Kumar S Saikatendu
21
,
Martin Schröder
6, 15, 16
,
Alexandra Stolz
5, 6, 15
,
Mariana Tellechea
5, 6, 15
,
Brandon J Turunen
22
,
Santiago Vilar
3
,
Jinhua Wang
12, 13
,
William J. Zuercher
1
,
Timothy M. Willson
1
,
David H. Drewry
1
3
Truvitech LLC, Miami, FL 33136, USA
|
9
Boehringer Ingelheim RCV GmbH & Co KG, 1121 Vienna, Austria
|
10
MSD, 33 Avenue Louis Pasteur, Boston, MA 02115, USA
|
11
Novartis Institutes for Biomedical Research, Novartis Campus, 4056 Basel, Switzerland
|
17
Bayer Pharma AG, Drug Discovery, Müllerstrasse 178, 13353 Berlin, Germany
|
18
Oncology Discovery, AbbVie, 1 North Waukegan Road, North Chicago, IL 60064, USA
|
20
Discovery Network Group, Pfizer Medicine Design, Cambridge, MA 02139, USA
|
21
Global Research Externalization, Takeda California, Inc., 9625 Towne Center Drive, San Diego, CA 92121, USA
|
22
GlaxoSmithKline, Chemical Biology, 1250 S Collegeville Rd, Collegeville, PA 19426, USA
|
Publication type: Journal Article
Publication date: 2021-01-08
scimago Q1
wos Q1
SJR: 1.273
CiteScore: 9.0
Impact factor: 4.9
ISSN: 16616596, 14220067
PubMed ID:
33429995
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
5
6
7
|
|
|
Pharmacological Research
7 publications, 8.64%
|
|
|
Journal of Medicinal Chemistry
6 publications, 7.41%
|
|
|
Methods in Molecular Biology
4 publications, 4.94%
|
|
|
Molecules
3 publications, 3.7%
|
|
|
RSC Medicinal Chemistry
3 publications, 3.7%
|
|
|
ACS Chemical Biology
3 publications, 3.7%
|
|
|
bioRxiv
3 publications, 3.7%
|
|
|
Drug Discovery Today
3 publications, 3.7%
|
|
|
Pharmaceutics
2 publications, 2.47%
|
|
|
Nature Communications
2 publications, 2.47%
|
|
|
Communications Chemistry
2 publications, 2.47%
|
|
|
Nature Chemical Biology
2 publications, 2.47%
|
|
|
European Journal of Medicinal Chemistry
2 publications, 2.47%
|
|
|
Alzheimer's and Dementia: Translational Research and Clinical Interventions
2 publications, 2.47%
|
|
|
Drug Development Research
1 publication, 1.23%
|
|
|
International Journal of Molecular Sciences
1 publication, 1.23%
|
|
|
Pharmaceuticals
1 publication, 1.23%
|
|
|
Journal of Lipid Research
1 publication, 1.23%
|
|
|
Software Impacts
1 publication, 1.23%
|
|
|
SLAS Discovery
1 publication, 1.23%
|
|
|
Plant Direct
1 publication, 1.23%
|
|
|
Current Protocols
1 publication, 1.23%
|
|
|
ChemBioChem
1 publication, 1.23%
|
|
|
Expert Opinion on Drug Discovery
1 publication, 1.23%
|
|
|
Science advances
1 publication, 1.23%
|
|
|
Annual Review of Biochemistry
1 publication, 1.23%
|
|
|
iScience
1 publication, 1.23%
|
|
|
Phytochemicals in Agriculture and Food [Working Title]
1 publication, 1.23%
|
|
|
Journal of Proteome Research
1 publication, 1.23%
|
|
|
1
2
3
4
5
6
7
|
Publishers
|
2
4
6
8
10
12
14
16
18
|
|
|
Elsevier
17 publications, 20.99%
|
|
|
Springer Nature
12 publications, 14.81%
|
|
|
Cold Spring Harbor Laboratory
12 publications, 14.81%
|
|
|
American Chemical Society (ACS)
11 publications, 13.58%
|
|
|
MDPI
8 publications, 9.88%
|
|
|
Wiley
5 publications, 6.17%
|
|
|
Royal Society of Chemistry (RSC)
3 publications, 3.7%
|
|
|
American Society for Biochemistry and Molecular Biology
1 publication, 1.23%
|
|
|
SAGE
1 publication, 1.23%
|
|
|
Taylor & Francis
1 publication, 1.23%
|
|
|
American Association for the Advancement of Science (AAAS)
1 publication, 1.23%
|
|
|
Annual Reviews
1 publication, 1.23%
|
|
|
IntechOpen
1 publication, 1.23%
|
|
|
PeerJ
1 publication, 1.23%
|
|
|
Frontiers Media S.A.
1 publication, 1.23%
|
|
|
eLife Sciences Publications
1 publication, 1.23%
|
|
|
Ovid Technologies (Wolters Kluwer Health)
1 publication, 1.23%
|
|
|
Public Library of Science (PLoS)
1 publication, 1.23%
|
|
|
Oxford University Press
1 publication, 1.23%
|
|
|
2
4
6
8
10
12
14
16
18
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
81
Total citations:
81
Citations from 2024:
24
(29.62%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Wells C. et al. The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification // International Journal of Molecular Sciences. 2021. Vol. 22. No. 2. p. 566.
GOST all authors (up to 50)
Copy
Wells C., Al-Ali H., Andrews D. M., Asquith C. R. M., Axtman A. D., Dikic I., Ebner D., Ettmayer P., Fischer C., Frederiksen M., Futrell R. E., Gray N., Hatch S. B., Knapp S., Lücking U., Michaelides M., Mills C. E., Müller S., Owen D., Picado A., Saikatendu K. S., Schröder M., Stolz A., Tellechea M., Turunen B. J., Vilar S., Wang J., Zuercher W. J., Willson T. M., Drewry D. H. The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification // International Journal of Molecular Sciences. 2021. Vol. 22. No. 2. p. 566.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/ijms22020566
UR - https://doi.org/10.3390/ijms22020566
TI - The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification
T2 - International Journal of Molecular Sciences
AU - Wells, Carrow
AU - Al-Ali, Hassan
AU - Andrews, David M
AU - Asquith, Christopher R M
AU - Axtman, Alison D
AU - Dikic, Ivan
AU - Ebner, Daniel
AU - Ettmayer, Peter
AU - Fischer, Christian
AU - Frederiksen, Mathias
AU - Futrell, Robert E
AU - Gray, Nathanael S.
AU - Hatch, Stephanie B
AU - Knapp, S.
AU - Lücking, Ulrich
AU - Michaelides, Michael
AU - Mills, Caitlin E
AU - Müller, Susanne
AU - Owen, Dafydd
AU - Picado, Alfredo
AU - Saikatendu, Kumar S
AU - Schröder, Martin
AU - Stolz, Alexandra
AU - Tellechea, Mariana
AU - Turunen, Brandon J
AU - Vilar, Santiago
AU - Wang, Jinhua
AU - Zuercher, William J.
AU - Willson, Timothy M.
AU - Drewry, David H.
PY - 2021
DA - 2021/01/08
PB - MDPI
SP - 566
IS - 2
VL - 22
PMID - 33429995
SN - 1661-6596
SN - 1422-0067
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Wells,
author = {Carrow Wells and Hassan Al-Ali and David M Andrews and Christopher R M Asquith and Alison D Axtman and Ivan Dikic and Daniel Ebner and Peter Ettmayer and Christian Fischer and Mathias Frederiksen and Robert E Futrell and Nathanael S. Gray and Stephanie B Hatch and S. Knapp and Ulrich Lücking and Michael Michaelides and Caitlin E Mills and Susanne Müller and Dafydd Owen and Alfredo Picado and Kumar S Saikatendu and Martin Schröder and Alexandra Stolz and Mariana Tellechea and Brandon J Turunen and Santiago Vilar and Jinhua Wang and William J. Zuercher and Timothy M. Willson and David H. Drewry},
title = {The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification},
journal = {International Journal of Molecular Sciences},
year = {2021},
volume = {22},
publisher = {MDPI},
month = {jan},
url = {https://doi.org/10.3390/ijms22020566},
number = {2},
pages = {566},
doi = {10.3390/ijms22020566}
}
Cite this
MLA
Copy
Wells, Carrow, et al. “The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification.” International Journal of Molecular Sciences, vol. 22, no. 2, Jan. 2021, p. 566. https://doi.org/10.3390/ijms22020566.