Open Access
Advances in Applying Computer-Aided Drug Design for Neurodegenerative Diseases
Mootaz M Salman
1, 2
,
Zaid Al-Obaidi
3, 4
,
Philip Kitchen
5
,
Andrea Loreto
1, 6
,
Roslyn Bill
5
,
Richard Wade-Martins
1, 2
1
3
Department of Pharmaceutical Chemistry, College of Pharmacy, University of Alkafeel, Najaf 54001, Iraq
|
Тип публикации: Journal Article
Дата публикации: 2021-04-28
scimago Q1
wos Q1
БС1
SJR: 1.273
CiteScore: 9.0
Impact factor: 4.9
ISSN: 16616596, 14220067
PubMed ID:
33925236
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Краткое описание
Neurodegenerative diseases (NDs) including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease are incurable and affect millions of people worldwide. The development of treatments for this unmet clinical need is a major global research challenge. Computer-aided drug design (CADD) methods minimize the huge number of ligands that could be screened in biological assays, reducing the cost, time, and effort required to develop new drugs. In this review, we provide an introduction to CADD and examine the progress in applying CADD and other molecular docking studies to NDs. We provide an updated overview of potential therapeutic targets for various NDs and discuss some of the advantages and disadvantages of these tools.
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Метрики
102
Всего цитирований:
102
Цитирований c 2024:
32
(31.38%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Salman M. M. et al. Advances in Applying Computer-Aided Drug Design for Neurodegenerative Diseases // International Journal of Molecular Sciences. 2021. Vol. 22. No. 9. p. 4688.
ГОСТ со всеми авторами (до 50)
Скопировать
Salman M. M., Al-Obaidi Z., Kitchen P., Loreto A., Bill R., Wade-Martins R. Advances in Applying Computer-Aided Drug Design for Neurodegenerative Diseases // International Journal of Molecular Sciences. 2021. Vol. 22. No. 9. p. 4688.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.3390/ijms22094688
UR - https://doi.org/10.3390/ijms22094688
TI - Advances in Applying Computer-Aided Drug Design for Neurodegenerative Diseases
T2 - International Journal of Molecular Sciences
AU - Salman, Mootaz M
AU - Al-Obaidi, Zaid
AU - Kitchen, Philip
AU - Loreto, Andrea
AU - Bill, Roslyn
AU - Wade-Martins, Richard
PY - 2021
DA - 2021/04/28
PB - MDPI
SP - 4688
IS - 9
VL - 22
PMID - 33925236
SN - 1661-6596
SN - 1422-0067
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2021_Salman,
author = {Mootaz M Salman and Zaid Al-Obaidi and Philip Kitchen and Andrea Loreto and Roslyn Bill and Richard Wade-Martins},
title = {Advances in Applying Computer-Aided Drug Design for Neurodegenerative Diseases},
journal = {International Journal of Molecular Sciences},
year = {2021},
volume = {22},
publisher = {MDPI},
month = {apr},
url = {https://doi.org/10.3390/ijms22094688},
number = {9},
pages = {4688},
doi = {10.3390/ijms22094688}
}
Цитировать
MLA
Скопировать
Salman, Mootaz M., et al. “Advances in Applying Computer-Aided Drug Design for Neurodegenerative Diseases.” International Journal of Molecular Sciences, vol. 22, no. 9, Apr. 2021, p. 4688. https://doi.org/10.3390/ijms22094688.