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International Journal of Molecular Sciences
,  том 22 ,  издание 21 ,  страницы 11525

Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats

Gohar Tsakanova 1, 2
, 
Nelly Babayan 1, 3
, 
Elena Karalova 1, 4
, 
Lina Hakobyan 1
, 
Liana Abroyan 1
, 
Aida Avetisyan 1, 4
, 
Hranush Avagyan 1, 4
, 
Sona Hakobyan 1
, 
Arpine Poghosyan 1
, 
Bagrat Baghdasaryan 1
, 
Elina Arakelova 1, 2
, 
Violetta Ayvazyan 1
, 
Lusine Matevosyan 1, 2
, 
Arpine Navasardyan 2
, 
Hakob Davtyan 2
, 
Lilit Apresyan 1
, 
Arsham Yeremyan 2
, 
Rouben Aroutiounian 1, 3
, 
Andreyan N. Osipov 5, 6, 7
, 
B Grigoryan 2
, 
Zaven Karalyan 1
1
 
2
 
CANDLE Synchrotron Research Institute, Yerevan 0040, Armenia | 
3
 
4
 
5
 
6
 
7
 
Тип публикации: Journal Article
Дата публикации: 2021-10-26
MDPI
scimago Q1
wos Q1
БС1
SJR: 1.273
CiteScore: 9.0
Impact factor: 4.9
ISSN: 16616596, 14220067
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Краткое описание

The development of new laser-driven electron linear accelerators, providing unique ultrashort pulsed electron beams (UPEBs) with low repetition rates, opens new opportunities for radiotherapy and new fronts for radiobiological research in general. Considering the growing interest in the application of UPEBs in radiation biology and medicine, the aim of this study was to reveal the changes in immune system in response to low-energy laser-driven UPEB whole-body irradiation in rodents. Forty male albino Wistar rats were exposed to laser-driven UPEB irradiation, after which different immunological parameters were studied on the 1st, 3rd, 7th, 14th, and 28th day after irradiation. According to the results, this type of irradiation induces alterations in the rat immune system, particularly by increasing the production of pro- and anti-inflammatory cytokines and elevating the DNA damage rate. Moreover, such an immune response reaches its maximal levels on the third day after laser-driven UPEB whole-body irradiation, showing partial recovery on subsequent days with a total recovery on the 28th day. The results of this study provide valuable insight into the effect of laser-driven UPEB whole-body irradiation on the immune system of the animals and support further animal experiments on the role of this novel type of irradiation.

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Tsakanova G. et al. Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats // International Journal of Molecular Sciences. 2021. Vol. 22. No. 21. p. 11525.
ГОСТ со всеми авторами (до 50) Скопировать
Tsakanova G., Babayan N., Karalova E., Hakobyan L., Abroyan L., Avetisyan A., Avagyan H., Hakobyan S., Poghosyan A., Baghdasaryan B., Arakelova E., Ayvazyan V., Matevosyan L., Navasardyan A., Davtyan H., Apresyan L., Yeremyan A., Aroutiounian R., Osipov A. N., Grigoryan B., Karalyan Z. Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats // International Journal of Molecular Sciences. 2021. Vol. 22. No. 21. p. 11525.
RIS |
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TY - JOUR
DO - 10.3390/ijms222111525
UR - https://doi.org/10.3390/ijms222111525
TI - Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats
T2 - International Journal of Molecular Sciences
AU - Tsakanova, Gohar
AU - Babayan, Nelly
AU - Karalova, Elena
AU - Hakobyan, Lina
AU - Abroyan, Liana
AU - Avetisyan, Aida
AU - Avagyan, Hranush
AU - Hakobyan, Sona
AU - Poghosyan, Arpine
AU - Baghdasaryan, Bagrat
AU - Arakelova, Elina
AU - Ayvazyan, Violetta
AU - Matevosyan, Lusine
AU - Navasardyan, Arpine
AU - Davtyan, Hakob
AU - Apresyan, Lilit
AU - Yeremyan, Arsham
AU - Aroutiounian, Rouben
AU - Osipov, Andreyan N.
AU - Grigoryan, B
AU - Karalyan, Zaven
PY - 2021
DA - 2021/10/26
PB - MDPI
SP - 11525
IS - 21
VL - 22
PMID - 34768958
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2021_Tsakanova,
author = {Gohar Tsakanova and Nelly Babayan and Elena Karalova and Lina Hakobyan and Liana Abroyan and Aida Avetisyan and Hranush Avagyan and Sona Hakobyan and Arpine Poghosyan and Bagrat Baghdasaryan and Elina Arakelova and Violetta Ayvazyan and Lusine Matevosyan and Arpine Navasardyan and Hakob Davtyan and Lilit Apresyan and Arsham Yeremyan and Rouben Aroutiounian and Andreyan N. Osipov and B Grigoryan and Zaven Karalyan},
title = {Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats},
journal = {International Journal of Molecular Sciences},
year = {2021},
volume = {22},
publisher = {MDPI},
month = {oct},
url = {https://doi.org/10.3390/ijms222111525},
number = {21},
pages = {11525},
doi = {10.3390/ijms222111525}
}
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Tsakanova, Gohar, et al. “Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats.” International Journal of Molecular Sciences, vol. 22, no. 21, Oct. 2021, p. 11525. https://doi.org/10.3390/ijms222111525.