Open Access
International Journal of Molecular Sciences, volume 24, issue 2, pages 1232
Structural and Functional RNA Motifs of SARS-CoV-2 and Influenza A Virus as a Target of Viral Inhibitors
Izabela Szczesniak
1
,
Agnieszka Baliga Gil
1
,
Aleksandra Jarmolowicz
1
,
Marta Soszynska Jozwiak
1
,
Elzbieta Kierzek
1
1
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland
|
Publication type: Journal Article
Publication date: 2023-01-08
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic, whereas the influenza A virus (IAV) causes seasonal epidemics and occasional pandemics. Both viruses lead to widespread infection and death. SARS-CoV-2 and the influenza virus are RNA viruses. The SARS-CoV-2 genome is an approximately 30 kb, positive sense, 5′ capped single-stranded RNA molecule. The influenza A virus genome possesses eight single-stranded negative-sense segments. The RNA secondary structure in the untranslated and coding regions is crucial in the viral replication cycle. The secondary structure within the RNA of SARS-CoV-2 and the influenza virus has been intensively studied. Because the whole of the SARS-CoV-2 and influenza virus replication cycles are dependent on RNA with no DNA intermediate, the RNA is a natural and promising target for the development of inhibitors. There are a lot of RNA-targeting strategies for regulating pathogenic RNA, such as small interfering RNA for RNA interference, antisense oligonucleotides, catalytic nucleic acids, and small molecules. In this review, we summarized the knowledge about the inhibition of SARS-CoV-2 and influenza A virus propagation by targeting their RNA secondary structure.
Top-30
Citations by journals
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1 publication, 9.09%
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Advanced Biotechnology
1 publication, 9.09%
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Proceedings of the National Academy of Sciences of the United States of America
1 publication, 9.09%
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1 publication, 9.09%
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1 publication, 9.09%
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Russian Chemical Reviews
1 publication, 9.09%
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1
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Citations by publishers
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3
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Elsevier
3 publications, 27.27%
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Springer Nature
2 publications, 18.18%
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 18.18%
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Taylor & Francis
1 publication, 9.09%
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Proceedings of the National Academy of Sciences (PNAS)
1 publication, 9.09%
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IWA Publishing
1 publication, 9.09%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 9.09%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Szczesniak I. et al. Structural and Functional RNA Motifs of SARS-CoV-2 and Influenza A Virus as a Target of Viral Inhibitors // International Journal of Molecular Sciences. 2023. Vol. 24. No. 2. p. 1232.
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Szczesniak I., Baliga Gil A., Jarmolowicz A., Soszynska Jozwiak M., Kierzek E. Structural and Functional RNA Motifs of SARS-CoV-2 and Influenza A Virus as a Target of Viral Inhibitors // International Journal of Molecular Sciences. 2023. Vol. 24. No. 2. p. 1232.
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TY - JOUR
DO - 10.3390/ijms24021232
UR - https://doi.org/10.3390/ijms24021232
TI - Structural and Functional RNA Motifs of SARS-CoV-2 and Influenza A Virus as a Target of Viral Inhibitors
T2 - International Journal of Molecular Sciences
AU - Szczesniak, Izabela
AU - Baliga Gil, Agnieszka
AU - Jarmolowicz, Aleksandra
AU - Soszynska Jozwiak, Marta
AU - Kierzek, Elzbieta
PY - 2023
DA - 2023/01/08 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1232
IS - 2
VL - 24
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2023_Szczesniak,
author = {Izabela Szczesniak and Agnieszka Baliga Gil and Aleksandra Jarmolowicz and Marta Soszynska Jozwiak and Elzbieta Kierzek},
title = {Structural and Functional RNA Motifs of SARS-CoV-2 and Influenza A Virus as a Target of Viral Inhibitors},
journal = {International Journal of Molecular Sciences},
year = {2023},
volume = {24},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jan},
url = {https://doi.org/10.3390/ijms24021232},
number = {2},
pages = {1232},
doi = {10.3390/ijms24021232}
}
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Szczesniak, Izabela, et al. “Structural and Functional RNA Motifs of SARS-CoV-2 and Influenza A Virus as a Target of Viral Inhibitors.” International Journal of Molecular Sciences, vol. 24, no. 2, Jan. 2023, p. 1232. https://doi.org/10.3390/ijms24021232.