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International Journal of Molecular Sciences, volume 24, issue 23, pages 16601

Identification of Anti-Neuroinflammatory Bioactive Compounds in Essential Oils and Aqueous Distillation Residues Obtained from Commercial Varieties of Cannabis sativa L.

Michela Freschi 1
Irene Rinaldi 1
Eugenia Mazzara 2
Tullia Maraldi 3
Marco Malaguti 1
Cecilia Prata 4
Publication typeJournal Article
Publication date2023-11-22
scimago Q1
wos Q2
SJR1.179
CiteScore8.1
Impact factor4.9
ISSN16616596, 14220067
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract

Neuroinflammation, which is mainly triggered by microglia, is a key contributor to multiple neurodegenerative diseases. Natural products, and in particular Cannabis sativa L., due to its richness in phytochemical components, represent ideal candidates to counteract neuroinflammation. We previously characterized different C. sativa commercial varieties which showed significantly different chemical profiles. On these bases, the aim of this study was to evaluate essential oils and aqueous distillation residues from the inflorescences of three different hemp varieties for their anti-neuroinflammatory activity in BV-2 microglial cells. Cells were pretreated with aqueous residues or essential oils and then activated with LPS. Unlike essential oils, aqueous residues showed negligible effects in terms of anti-inflammatory activity. Among the essential oils, the one obtained from ‘Gorilla Glue’ was the most effective in inhibiting pro-inflammatory mediators and in upregulating anti-inflammatory ones through the modulation of the p38 MAPK/NF-κB pathway. Moreover, the sesquiterpenes (E)-caryophyllene, α-humulene, and caryophyllene oxide were identified as the main contributors to the essential oils’ anti-inflammatory activity. To our knowledge, the anti-neuroinflammatory activity of α-humulene has not been previously described. In conclusion, our work shows that C. sativa essential oils characterized by high levels of sesquiterpenes can be promising candidates in the prevention/counteraction of neuroinflammation.

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Barbalace M. C. et al. Identification of Anti-Neuroinflammatory Bioactive Compounds in Essential Oils and Aqueous Distillation Residues Obtained from Commercial Varieties of Cannabis sativa L. // International Journal of Molecular Sciences. 2023. Vol. 24. No. 23. p. 16601.
GOST all authors (up to 50) Copy
Barbalace M. C., Freschi M., Rinaldi I., Mazzara E., Maraldi T., Malaguti M., Prata C., Maggi F., Petrelli R., Hrelia S., Angeloni C. Identification of Anti-Neuroinflammatory Bioactive Compounds in Essential Oils and Aqueous Distillation Residues Obtained from Commercial Varieties of Cannabis sativa L. // International Journal of Molecular Sciences. 2023. Vol. 24. No. 23. p. 16601.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3390/ijms242316601
UR - https://doi.org/10.3390/ijms242316601
TI - Identification of Anti-Neuroinflammatory Bioactive Compounds in Essential Oils and Aqueous Distillation Residues Obtained from Commercial Varieties of Cannabis sativa L.
T2 - International Journal of Molecular Sciences
AU - Barbalace, Maria Cristina
AU - Freschi, Michela
AU - Rinaldi, Irene
AU - Mazzara, Eugenia
AU - Maraldi, Tullia
AU - Malaguti, Marco
AU - Prata, Cecilia
AU - Maggi, Filippo
AU - Petrelli, Riccardo
AU - Hrelia, Silvana
AU - Angeloni, Cristina
PY - 2023
DA - 2023/11/22
PB - MDPI
SP - 16601
IS - 23
VL - 24
SN - 1661-6596
SN - 1422-0067
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Barbalace,
author = {Maria Cristina Barbalace and Michela Freschi and Irene Rinaldi and Eugenia Mazzara and Tullia Maraldi and Marco Malaguti and Cecilia Prata and Filippo Maggi and Riccardo Petrelli and Silvana Hrelia and Cristina Angeloni},
title = {Identification of Anti-Neuroinflammatory Bioactive Compounds in Essential Oils and Aqueous Distillation Residues Obtained from Commercial Varieties of Cannabis sativa L.},
journal = {International Journal of Molecular Sciences},
year = {2023},
volume = {24},
publisher = {MDPI},
month = {nov},
url = {https://doi.org/10.3390/ijms242316601},
number = {23},
pages = {16601},
doi = {10.3390/ijms242316601}
}
MLA
Cite this
MLA Copy
Barbalace, Maria Cristina, et al. “Identification of Anti-Neuroinflammatory Bioactive Compounds in Essential Oils and Aqueous Distillation Residues Obtained from Commercial Varieties of Cannabis sativa L..” International Journal of Molecular Sciences, vol. 24, no. 23, Nov. 2023, p. 16601. https://doi.org/10.3390/ijms242316601.
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