Open Access
Non-Small Cell Lung Cancer Harboring Concurrent EGFR Genomic Alterations: A Systematic Review and Critical Appraisal of the Double Dilemma
Valerio Gristina
1
,
Maria La Mantia
1
,
Antonio Galvano
1
,
Sofia Cutaia
1
,
Nadia Barraco
1
,
Marta Castiglia
1
,
Alessandro Perez
1
,
Marco Bono
1
,
Federica Iacono
1
,
Martina Greco
1
,
Katia Calcara
1
,
Valentina Calò
1
,
Sergio Rizzo
1
,
Lorena Incorvaia
1
,
Maria Chiara Lisanti
1
,
Giulia Santanelli
1
,
Delia Sardo
1
,
Sara Inguglia
1
,
Lavinia Insalaco
1
,
Luisa Castellana
1
,
Stefania Cusenza
1
,
Gianni Pantuso
1
,
Antonio Russo
1
,
Viviana Bazan
2
Publication type: Journal Article
Publication date: 2021-06-04
scimago Q2
wos Q3
SJR: 0.403
CiteScore: 2.3
Impact factor: 1.1
ISSN: 26735261
General Medicine
Abstract
The molecular pathways which promote lung cancer cell features have been broadly explored, leading to significant improvement in prognostic and diagnostic strategies. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have dramatically altered the treatment approach for patients with metastatic non-small cell lung cancer (NSCLC). Latest investigations by using next-generation sequencing (NGS) have shown that other oncogenic driver mutations, believed mutually exclusive for decades, could coexist in EGFR-mutated NSCLC patients. However, the exact clinical and pathological role of concomitant genomic aberrations needs to be investigated. In this systematic review, we aimed to summarize the recent data on the oncogenic role of concurrent genomic alterations, by specifically evaluating the characteristics, the pathological significance, and their potential impact on the treatment approach.
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Total citations:
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Citations from 2024:
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(35%)
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BibTex |
MLA
Cite this
GOST
Copy
Gristina V. et al. Non-Small Cell Lung Cancer Harboring Concurrent EGFR Genomic Alterations: A Systematic Review and Critical Appraisal of the Double Dilemma // Journal of Molecular Pathology. 2021. Vol. 2. No. 2. pp. 173-196.
GOST all authors (up to 50)
Copy
Gristina V., La Mantia M., Galvano A., Cutaia S., Barraco N., Castiglia M., Perez A., Bono M., Iacono F., Greco M., Calcara K., Calò V., Rizzo S., Incorvaia L., Lisanti M. C., Santanelli G., Sardo D., Inguglia S., Insalaco L., Castellana L., Cusenza S., Pantuso G., Russo A., Bazan V. Non-Small Cell Lung Cancer Harboring Concurrent EGFR Genomic Alterations: A Systematic Review and Critical Appraisal of the Double Dilemma // Journal of Molecular Pathology. 2021. Vol. 2. No. 2. pp. 173-196.
Cite this
RIS
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TY - JOUR
DO - 10.3390/jmp2020016
UR - https://doi.org/10.3390/jmp2020016
TI - Non-Small Cell Lung Cancer Harboring Concurrent EGFR Genomic Alterations: A Systematic Review and Critical Appraisal of the Double Dilemma
T2 - Journal of Molecular Pathology
AU - Gristina, Valerio
AU - La Mantia, Maria
AU - Galvano, Antonio
AU - Cutaia, Sofia
AU - Barraco, Nadia
AU - Castiglia, Marta
AU - Perez, Alessandro
AU - Bono, Marco
AU - Iacono, Federica
AU - Greco, Martina
AU - Calcara, Katia
AU - Calò, Valentina
AU - Rizzo, Sergio
AU - Incorvaia, Lorena
AU - Lisanti, Maria Chiara
AU - Santanelli, Giulia
AU - Sardo, Delia
AU - Inguglia, Sara
AU - Insalaco, Lavinia
AU - Castellana, Luisa
AU - Cusenza, Stefania
AU - Pantuso, Gianni
AU - Russo, Antonio
AU - Bazan, Viviana
PY - 2021
DA - 2021/06/04
PB - MDPI
SP - 173-196
IS - 2
VL - 2
SN - 2673-5261
ER -
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BibTex (up to 50 authors)
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@article{2021_Gristina,
author = {Valerio Gristina and Maria La Mantia and Antonio Galvano and Sofia Cutaia and Nadia Barraco and Marta Castiglia and Alessandro Perez and Marco Bono and Federica Iacono and Martina Greco and Katia Calcara and Valentina Calò and Sergio Rizzo and Lorena Incorvaia and Maria Chiara Lisanti and Giulia Santanelli and Delia Sardo and Sara Inguglia and Lavinia Insalaco and Luisa Castellana and Stefania Cusenza and Gianni Pantuso and Antonio Russo and Viviana Bazan},
title = {Non-Small Cell Lung Cancer Harboring Concurrent EGFR Genomic Alterations: A Systematic Review and Critical Appraisal of the Double Dilemma},
journal = {Journal of Molecular Pathology},
year = {2021},
volume = {2},
publisher = {MDPI},
month = {jun},
url = {https://doi.org/10.3390/jmp2020016},
number = {2},
pages = {173--196},
doi = {10.3390/jmp2020016}
}
Cite this
MLA
Copy
Gristina, Valerio, et al. “Non-Small Cell Lung Cancer Harboring Concurrent EGFR Genomic Alterations: A Systematic Review and Critical Appraisal of the Double Dilemma.” Journal of Molecular Pathology, vol. 2, no. 2, Jun. 2021, pp. 173-196. https://doi.org/10.3390/jmp2020016.