Open Access
Synthesis of New 1,2,3,4-Tetrahydroquinoline Hybrid of Ibuprofen and Its Biological Evaluation
Publication type: Journal Article
Publication date: 2022-03-07
DOI:
10.3390/m1350
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
Herein we report the obtaining of 1-(3,4-dihydroquinolin-1(2H)-yl)-2- (4-isobutylphenyl)propan-1-one and its characterization. The newly obtained hybrid and its derivatives (hybrids of ibuprofen with 1,2,3,4-tetrahydroisoquinoline, and piperidine) were screened for their in vitro antioxidant, antitryptic, and inhibition of albumin denaturation activity. The lipophilicity was established using both reversed-phase thin layer chromatography and in silico calculations.
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Citations from 2024:
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(58.33%)
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Manolov S., Ivanov I., Bojilov D. Synthesis of New 1,2,3,4-Tetrahydroquinoline Hybrid of Ibuprofen and Its Biological Evaluation // MolBank. 2022. Vol. 2022. No. 1. p. M1350.
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Manolov S., Ivanov I., Bojilov D. Synthesis of New 1,2,3,4-Tetrahydroquinoline Hybrid of Ibuprofen and Its Biological Evaluation // MolBank. 2022. Vol. 2022. No. 1. p. M1350.
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TY - JOUR
DO - 10.3390/m1350
UR - https://doi.org/10.3390/m1350
TI - Synthesis of New 1,2,3,4-Tetrahydroquinoline Hybrid of Ibuprofen and Its Biological Evaluation
T2 - MolBank
AU - Manolov, Stanimir
AU - Ivanov, Iliyan
AU - Bojilov, Dimitar
PY - 2022
DA - 2022/03/07
PB - MDPI
SP - M1350
IS - 1
VL - 2022
SN - 1422-8599
ER -
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BibTex (up to 50 authors)
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@article{2022_Manolov,
author = {Stanimir Manolov and Iliyan Ivanov and Dimitar Bojilov},
title = {Synthesis of New 1,2,3,4-Tetrahydroquinoline Hybrid of Ibuprofen and Its Biological Evaluation},
journal = {MolBank},
year = {2022},
volume = {2022},
publisher = {MDPI},
month = {mar},
url = {https://doi.org/10.3390/m1350},
number = {1},
pages = {M1350},
doi = {10.3390/m1350}
}
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MLA
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Manolov, Stanimir, et al. “Synthesis of New 1,2,3,4-Tetrahydroquinoline Hybrid of Ibuprofen and Its Biological Evaluation.” MolBank, vol. 2022, no. 1, Mar. 2022, p. M1350. https://doi.org/10.3390/m1350.