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,  volume 2023 ,  issue 1 ,  pages M1572

(3-(1H-Indol-3-yl)-2-(7,8,12,13-tetraoxa-10-azaspiro[5.7]tridecan-10-yl)propanoic acid) with Cytotoxic Activity

Publication type: Journal Article
Publication date: 2023-02-01
MDPI
scimago Q4
wos Q4
SJR: 0.142
CiteScore: 0.9
Impact factor: 0.4
ISSN: 14228599
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract

An efficient method for the synthesis of 3-(1H-indol-3-yl)-2-(7,8,12,13-tetraoxa-10-azaspiro[5.7]tridecan-10-yl)propanoic acid) via condensation of 7,8,10,12,13-pentaoxaspiro[5.7]tridecane with tryptophan under the action of a catalyst based on Sm(NO3)3·6H2O has been developed. A high cytotoxic activity of eight-membered azadiperoxide against tumor cells Jurkat, K562, U937, and HL60 was established. Additionally, this compound is an inducer of apoptosis and affects the cell cycle.

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Makhmudiyarova N. N. et al. (3-(1H-Indol-3-yl)-2-(7,8,12,13-tetraoxa-10-azaspiro[5.7]tridecan-10-yl)propanoic acid) with Cytotoxic Activity // MolBank. 2023. Vol. 2023. No. 1. p. M1572.
GOST all authors (up to 50) Copy
Makhmudiyarova N. N., Ishmukhametova I. R., Dzhemileva L. U., Dzhemilev U. M. (3-(1H-Indol-3-yl)-2-(7,8,12,13-tetraoxa-10-azaspiro[5.7]tridecan-10-yl)propanoic acid) with Cytotoxic Activity // MolBank. 2023. Vol. 2023. No. 1. p. M1572.
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TY - JOUR
DO - 10.3390/m1572
UR - https://doi.org/10.3390/m1572
TI - (3-(1H-Indol-3-yl)-2-(7,8,12,13-tetraoxa-10-azaspiro[5.7]tridecan-10-yl)propanoic acid) with Cytotoxic Activity
T2 - MolBank
AU - Makhmudiyarova, Nataliya N.
AU - Ishmukhametova, Irina R.
AU - Dzhemileva, Lilya U.
AU - Dzhemilev, Usein M.
PY - 2023
DA - 2023/02/01
PB - MDPI
SP - M1572
IS - 1
VL - 2023
SN - 1422-8599
ER -
BibTex |
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@article{2023_Makhmudiyarova,
author = {Nataliya N. Makhmudiyarova and Irina R. Ishmukhametova and Lilya U. Dzhemileva and Usein M. Dzhemilev},
title = {(3-(1H-Indol-3-yl)-2-(7,8,12,13-tetraoxa-10-azaspiro[5.7]tridecan-10-yl)propanoic acid) with Cytotoxic Activity},
journal = {MolBank},
year = {2023},
volume = {2023},
publisher = {MDPI},
month = {feb},
url = {https://doi.org/10.3390/m1572},
number = {1},
pages = {M1572},
doi = {10.3390/m1572}
}
MLA
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Makhmudiyarova, Nataliya N., et al. “(3-(1H-Indol-3-yl)-2-(7,8,12,13-tetraoxa-10-azaspiro[5.7]tridecan-10-yl)propanoic acid) with Cytotoxic Activity.” MolBank, vol. 2023, no. 1, Feb. 2023, p. M1572. https://doi.org/10.3390/m1572.