Open Access
Marine Drugs, volume 20, issue 9, pages 584
Cytotoxic Drimane-Type Sesquiterpenes from Co-Culture of the Marine-Derived Fungi Aspergillus carneus KMM 4638 and Beauveria felina (=Isaria felina) KMM 4639
Zhuravleva Olesya I
1, 2
,
Belousova Elena B
1, 2
,
Antonov Alexandr S.
1
,
Khudyakova Yuliya V
1
,
Rasin Anton B
1
,
Menchinskaya Ekaterina S
1
,
Trinh Phan Thi Hoai
3
,
Publication type: Journal Article
Publication date: 2022-09-19
PubMed ID:
36135773
Drug Discovery
Pharmaceutical Science
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Abstract
Chemical investigation of a coculture of the marine-derived fungi Beauveria felina KMM 4639 and Aspergillus carneus KMM 4638 led to the identification of three new drimane-type sesquiterpenes, asperflavinoids B, D and E (2, 4, 5), and nine previously reported related compounds. The structures of these compounds were established using spectroscopic methods and by comparison with known analogues. We also investigated the cytotoxic activity of the isolated compounds against several cancer and normal cell lines. Asperflavinoid C (3) and ustusolate E (9) exerted a significant effect on human breast cancer MCF-7 cell viability, with IC50 values of 10 µM, and induced in caspase-dependent apoptosis and arrest of the MCF-7 cell cycle in the G2/M phase in these cells.
Citations by journals
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1
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Microorganisms
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Microorganisms
1 publication, 12.5%
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Archives of Pharmacal Research
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Archives of Pharmacal Research
1 publication, 12.5%
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Biomolecules
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Biomolecules
1 publication, 12.5%
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Molecules
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Molecules
1 publication, 12.5%
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Fitoterapia
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Fitoterapia
1 publication, 12.5%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 12.5%
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Phytochemistry
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Phytochemistry
1 publication, 12.5%
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Natural Product Reports
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Natural Product Reports
1 publication, 12.5%
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1
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Citations by publishers
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1
2
3
4
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 50%
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Elsevier
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Elsevier
2 publications, 25%
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Pharmaceutical Society of Korea
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Pharmaceutical Society of Korea
1 publication, 12.5%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
1 publication, 12.5%
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1
2
3
4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Zhuravleva O. I. et al. Cytotoxic Drimane-Type Sesquiterpenes from Co-Culture of the Marine-Derived Fungi Aspergillus carneus KMM 4638 and Beauveria felina (=Isaria felina) KMM 4639 // Marine Drugs. 2022. Vol. 20. No. 9. p. 584.
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Zhuravleva O. I., Belousova E. B., Oleinikova G. K., Antonov A. S., Khudyakova Y. V., Rasin A. B., Menchinskaya E. S., Trinh P. T. H., Yurchenko A. N., YURCHENKO E. Y. Cytotoxic Drimane-Type Sesquiterpenes from Co-Culture of the Marine-Derived Fungi Aspergillus carneus KMM 4638 and Beauveria felina (=Isaria felina) KMM 4639 // Marine Drugs. 2022. Vol. 20. No. 9. p. 584.
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TY - JOUR
DO - 10.3390/md20090584
UR - https://doi.org/10.3390%2Fmd20090584
TI - Cytotoxic Drimane-Type Sesquiterpenes from Co-Culture of the Marine-Derived Fungi Aspergillus carneus KMM 4638 and Beauveria felina (=Isaria felina) KMM 4639
T2 - Marine Drugs
AU - Belousova, Elena B
AU - Oleinikova, Galina K
AU - Antonov, Alexandr S.
AU - Khudyakova, Yuliya V
AU - Rasin, Anton B
AU - Menchinskaya, Ekaterina S
AU - Trinh, Phan Thi Hoai
AU - Zhuravleva, Olesya I
AU - Yurchenko, Anton N
AU - YURCHENKO, EKATERINA Y.
PY - 2022
DA - 2022/09/19 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 584
IS - 9
VL - 20
PMID - 36135773
SN - 1660-3397
ER -
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@article{2022_Zhuravleva,
author = {Elena B Belousova and Galina K Oleinikova and Alexandr S. Antonov and Yuliya V Khudyakova and Anton B Rasin and Ekaterina S Menchinskaya and Phan Thi Hoai Trinh and Olesya I Zhuravleva and Anton N Yurchenko and EKATERINA Y. YURCHENKO},
title = {Cytotoxic Drimane-Type Sesquiterpenes from Co-Culture of the Marine-Derived Fungi Aspergillus carneus KMM 4638 and Beauveria felina (=Isaria felina) KMM 4639},
journal = {Marine Drugs},
year = {2022},
volume = {20},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {sep},
url = {https://doi.org/10.3390%2Fmd20090584},
number = {9},
pages = {584},
doi = {10.3390/md20090584}
}
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MLA
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Zhuravleva, Olesya I., et al. “Cytotoxic Drimane-Type Sesquiterpenes from Co-Culture of the Marine-Derived Fungi Aspergillus carneus KMM 4638 and Beauveria felina (=Isaria felina) KMM 4639.” Marine Drugs, vol. 20, no. 9, Sep. 2022, p. 584. https://doi.org/10.3390%2Fmd20090584.