Open Access
Membranes, volume 12, issue 6, pages 618
Extracellular Particles as Carriers of Cholesterol Not Associated with Lipoproteins
Landa Sergey
1, 2
,
Verlov Nikolay
1, 3
,
Fedorova Natalia
1
,
Filatov Mikhail
1
,
Pantina Rimma
1
,
Burdakov Vladimir
1
,
Varfolomeeva Elena
1
,
Emanuel Vladimir
2
1
3
Saint Petersburg Clinical Research and Practical Center of Specialized Types of Medical Care (Oncological), 196605 Saint Petersburg, Russia
|
Publication type: Journal Article
Publication date: 2022-06-14
Process Chemistry and Technology
Chemical Engineering (miscellaneous)
Filtration and Separation
Abstract
Exosomes and exomeres are the smallest microparticles ranging from 20 to 130 nm in diameter. They are found in almost all biological fluids. Exosomes and exomeres are of considerable interest since they can be involved in intercellular signaling and are biological markers of the state of cells, which can be used for diagnostics. The nomenclature of exosomes remains poorly developed. Most researchers try to classify them based on the mode of formation, physicochemical characteristics, and the presence of tetrasporin markers CD9, CD63, and CD81. The data presented in this work show that although exomeres carry tetrasporin biomarkers, they differ from exosomes strongly in lipid composition, especially in cholesterol content. The production of exomeres by cells is associated with the synthesis of cholesterol in cells and is expressed or suppressed by regulators of the synthesis of mevalonate, an intermediate product of cholesterol metabolism. In addition, the work shows that the concentration of extracellular particles in the body correlates with the concentration of cholesterol in the plasma, but weakly correlates with the concentration of cholesterol in lipoproteins. This suggests that not all plasma cholesterol is associated with lipoproteins, as previously thought.
Citations by journals
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1
2
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PLoS ONE
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PLoS ONE
2 publications, 40%
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Vaccines
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Vaccines
1 publication, 20%
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Cancer Letters
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Cancer Letters
1 publication, 20%
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1
2
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Citations by publishers
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1
2
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Public Library of Science (PLoS)
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Public Library of Science (PLoS)
2 publications, 40%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 20%
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Elsevier
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Elsevier
1 publication, 20%
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1
2
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- We do not take into account publications that without a DOI.
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Landa S. et al. Extracellular Particles as Carriers of Cholesterol Not Associated with Lipoproteins // Membranes. 2022. Vol. 12. No. 6. p. 618.
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Landa S., Verlov N., Fedorova N., Filatov M., Pantina R., Burdakov V., Varfolomeeva E., Emanuel V. Extracellular Particles as Carriers of Cholesterol Not Associated with Lipoproteins // Membranes. 2022. Vol. 12. No. 6. p. 618.
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TY - JOUR
DO - 10.3390/membranes12060618
UR - https://doi.org/10.3390%2Fmembranes12060618
TI - Extracellular Particles as Carriers of Cholesterol Not Associated with Lipoproteins
T2 - Membranes
AU - Landa, Sergey
AU - Filatov, Mikhail
AU - Pantina, Rimma
AU - Burdakov, Vladimir
AU - Varfolomeeva, Elena
AU - Emanuel, Vladimir
AU - Verlov, Nikolay
AU - Fedorova, Natalia
PY - 2022
DA - 2022/06/14 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 618
IS - 6
VL - 12
SN - 2077-0375
ER -
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@article{2022_Landa,
author = {Sergey Landa and Mikhail Filatov and Rimma Pantina and Vladimir Burdakov and Elena Varfolomeeva and Vladimir Emanuel and Nikolay Verlov and Natalia Fedorova},
title = {Extracellular Particles as Carriers of Cholesterol Not Associated with Lipoproteins},
journal = {Membranes},
year = {2022},
volume = {12},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jun},
url = {https://doi.org/10.3390%2Fmembranes12060618},
number = {6},
pages = {618},
doi = {10.3390/membranes12060618}
}
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MLA
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Landa, Sergey, et al. “Extracellular Particles as Carriers of Cholesterol Not Associated with Lipoproteins.” Membranes, vol. 12, no. 6, Jun. 2022, p. 618. https://doi.org/10.3390%2Fmembranes12060618.
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