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Molecules
,  том 29 ,  издание 3 ,  страницы 613

Penisimplicins A and B: Novel Polyketide–Peptide Hybrid Alkaloids from the Fungus Penicillium simplicissimum JXCC5

Тип публикации: Journal Article
Дата публикации: 2024-01-27
MDPI
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SJR: 0.915
CiteScore: 8.6
Impact factor: 4.6
ISSN: 14203049
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
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In this study, two previously undescribed nitrogen-containing compounds, penisimplicins A (1) and B (2), were isolated from Penicillium simplicissimum JXCC5. The structures of 1 and 2 were elucidated on the basis of comprehensive spectroscopic data analysis, including 1D and 2D NMR and HRESIMS data. The absolute configuration of 2 was determined by Marfey’s method, ECD calculation, and DP4+ analysis. Both structures of 1 and 2 feature an unprecedented manner of amino acid-derivatives attaching to a polyketide moiety by C-C bond. The postulated biosynthetic pathways for 1 and 2 were discussed. Additionally, compound 1 exhibited significant acetylcholinesterase inhibitory activity, with IC50 values of 6.35 μM.

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Wang Q. et al. Penisimplicins A and B: Novel Polyketide–Peptide Hybrid Alkaloids from the Fungus Penicillium simplicissimum JXCC5 // Molecules. 2024. Vol. 29. No. 3. p. 613.
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Wang Q., Gao Y., Yao J., Zhou L., Chen H. P., Liu J. Penisimplicins A and B: Novel Polyketide–Peptide Hybrid Alkaloids from the Fungus Penicillium simplicissimum JXCC5 // Molecules. 2024. Vol. 29. No. 3. p. 613.
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TY - JOUR
DO - 10.3390/molecules29030613
UR - https://doi.org/10.3390/molecules29030613
TI - Penisimplicins A and B: Novel Polyketide–Peptide Hybrid Alkaloids from the Fungus Penicillium simplicissimum JXCC5
T2 - Molecules
AU - Wang, Qing-Yuan
AU - Gao, Yang
AU - Yao, Jian-Neng
AU - Zhou, Li
AU - Chen, He Ping
AU - Liu, Ji-Kai
PY - 2024
DA - 2024/01/27
PB - MDPI
SP - 613
IS - 3
VL - 29
PMID - 38338359
SN - 1420-3049
ER -
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@article{2024_Wang,
author = {Qing-Yuan Wang and Yang Gao and Jian-Neng Yao and Li Zhou and He Ping Chen and Ji-Kai Liu},
title = {Penisimplicins A and B: Novel Polyketide–Peptide Hybrid Alkaloids from the Fungus Penicillium simplicissimum JXCC5},
journal = {Molecules},
year = {2024},
volume = {29},
publisher = {MDPI},
month = {jan},
url = {https://doi.org/10.3390/molecules29030613},
number = {3},
pages = {613},
doi = {10.3390/molecules29030613}
}
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Wang, Qing-Yuan, et al. “Penisimplicins A and B: Novel Polyketide–Peptide Hybrid Alkaloids from the Fungus Penicillium simplicissimum JXCC5.” Molecules, vol. 29, no. 3, Jan. 2024, p. 613. https://doi.org/10.3390/molecules29030613.
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