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Molecules
,  том 30 ,  издание 1 ,  страницы 117

Novel Chlorin with a HYNIC: Synthesis, 99mTc-Radiolabeling, and Initial Preclinical Evaluation

Alexander Popov 1
, 
Nikita Suvorov 1
, 
Maria Larkina 2, 3
, 
Evgenii Plotnikov 2, 3
, 
Ruslan Varvashenya 2, 3
, 
Vitalina Bodenko 2, 3
, 
Gleb Yanovich 2, 3
, 
Petr Ostroverkhov 1
, 
Maxim Usachev 1
, 
Elena Filonenko 1, 4
, 
Mikhail V Belousov 5
, 
Mikhail Grin 1
1
 
2
 
3
 
4
 
5
 
Тип публикации: Journal Article
Дата публикации: 2024-12-31
MDPI
scimago Q1
wos Q2
БС1
SJR: 0.865
CiteScore: 8.6
Impact factor: 4.6
ISSN: 14203049
Краткое описание

The use of radiopharmaceuticals for diagnostics in oncology allows for the detection of the disease at an early stage. Among diagnostic radionuclides, 99mTc is a promising isotope that has been used to create several drugs for clinical use. One of the most effective 99mTc chelators is 6-hydrazinylnicotinic acid (HYNIC), which, when combined with various vector molecules, can be used for targeted delivery of radionuclides to tumor tissues. At the same time, it is known that tetrapyrrole macrocycles are capable of selective accumulation in tumors, and thus can be used to target radiopharmaceuticals with 99mTc. In this work, the conjugate of natural chlorin and HYNIC was obtained, and preliminary preclinical studies were carried out on its radiocomplex with 99mTc.

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Топ-30

Журналы

1
Biochemistry (Moscow)
Biochemistry (Moscow), 1, 100%
Biochemistry (Moscow)
1 публикация, 100%
1

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1
Pleiades Publishing
Pleiades Publishing, 1, 100%
Pleiades Publishing
1 публикация, 100%
1
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Popov A. et al. Novel Chlorin with a HYNIC: Synthesis, 99mTc-Radiolabeling, and Initial Preclinical Evaluation // Molecules. 2024. Vol. 30. No. 1. p. 117.
ГОСТ со всеми авторами (до 50) Скопировать
Popov A., Suvorov N., Larkina M., Plotnikov E., Varvashenya R., Bodenko V., Yanovich G., Ostroverkhov P., Usachev M., Filonenko E., Belousov M. V., Grin M. Novel Chlorin with a HYNIC: Synthesis, 99mTc-Radiolabeling, and Initial Preclinical Evaluation // Molecules. 2024. Vol. 30. No. 1. p. 117.
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TY - JOUR
DO - 10.3390/molecules30010117
UR - https://www.mdpi.com/1420-3049/30/1/117
TI - Novel Chlorin with a HYNIC: Synthesis, 99mTc-Radiolabeling, and Initial Preclinical Evaluation
T2 - Molecules
AU - Popov, Alexander
AU - Suvorov, Nikita
AU - Larkina, Maria
AU - Plotnikov, Evgenii
AU - Varvashenya, Ruslan
AU - Bodenko, Vitalina
AU - Yanovich, Gleb
AU - Ostroverkhov, Petr
AU - Usachev, Maxim
AU - Filonenko, Elena
AU - Belousov, Mikhail V
AU - Grin, Mikhail
PY - 2024
DA - 2024/12/31
PB - MDPI
SP - 117
IS - 1
VL - 30
SN - 1420-3049
ER -
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@article{2024_Popov,
author = {Alexander Popov and Nikita Suvorov and Maria Larkina and Evgenii Plotnikov and Ruslan Varvashenya and Vitalina Bodenko and Gleb Yanovich and Petr Ostroverkhov and Maxim Usachev and Elena Filonenko and Mikhail V Belousov and Mikhail Grin},
title = {Novel Chlorin with a HYNIC: Synthesis, 99mTc-Radiolabeling, and Initial Preclinical Evaluation},
journal = {Molecules},
year = {2024},
volume = {30},
publisher = {MDPI},
month = {dec},
url = {https://www.mdpi.com/1420-3049/30/1/117},
number = {1},
pages = {117},
doi = {10.3390/molecules30010117}
}
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Popov, Alexander, et al. “Novel Chlorin with a HYNIC: Synthesis, 99mTc-Radiolabeling, and Initial Preclinical Evaluation.” Molecules, vol. 30, no. 1, Dec. 2024, p. 117. https://www.mdpi.com/1420-3049/30/1/117.