Quinolin-4-ones: Methods of Synthesis and Application in Medicine
Quinolinones, also called quinolones, are a group of heterocyclic compounds with a broad spectrum of biological activities. These compounds occur naturally in plants and microorganisms but can also be obtained synthetically. The first synthesis of quinolinones took place at the end of the 19th century, and the most recent methods were published just a few years ago. They allow for obtaining an unlimited number of analogs differing in biological properties. In this review, we described the plethora of methods leading to quinolin-4-ones. Several of these compounds have been used as antibiotics for over four decades, but recently, their antiproliferative effects have been of particular interest to researchers. This review summarizes the experimental progress made in the synthetic development of various routes leading to quinoline-4-ones and presents an overview of the structures, their evolution, and their relation to activity.
Топ-30
Журналы
|
1
|
|
|
Pharmaceuticals
1 публикация, 25%
|
|
|
RSC Advances
1 публикация, 25%
|
|
|
Journal of Organic Chemistry
1 публикация, 25%
|
|
|
Organic and Biomolecular Chemistry
1 публикация, 25%
|
|
|
1
|
Издатели
|
1
2
|
|
|
Royal Society of Chemistry (RSC)
2 публикации, 50%
|
|
|
MDPI
1 публикация, 25%
|
|
|
American Chemical Society (ACS)
1 публикация, 25%
|
|
|
1
2
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.