Open Access
Nanomaterials, volume 11, issue 6, pages 1459
Magnetic Nanodiscs—A New Promising Tool for Microsurgery of Malignant Neoplasms
Zamay Tatiana N.
1, 2
,
Prokopenko Vladimir S.
3
,
Zamay Sergey S
4
,
Lukyanenko Kirill A.
1, 2, 5
,
Kolovskaya Olga S
1, 2
,
Orlov Vitaly A
6, 7
,
Zamay Galina S
1, 2
,
Galeev Rinat G
8
,
Narodov Andrey A
9
,
Kichkailo Anna S.
1, 2
8
JSC «NPP «Radiosviaz», 660021 Krasnoyarsk, Russia
|
Publication type: Journal Article
Publication date: 2021-05-31
PubMed ID:
34072903
General Chemical Engineering
General Materials Science
Abstract
Magnetomechanical therapy is one of the most perspective directions in tumor microsurgery. According to the analysis of recent publications, it can be concluded that a nanoscalpel could become an instrument sufficient for cancer microsurgery. It should possess the following properties: (1) nano- or microsized; (2) affinity and specificity to the targets on tumor cells; (3) remote control. This nano- or microscalpel should include at least two components: (1) a physical nanostructure (particle, disc, plates) with the ability to transform the magnetic moment to mechanical torque; (2) a ligand—a molecule (antibody, aptamer, etc.) allowing the scalpel precisely target tumor cells. Literature analysis revealed that the most suitable nanoscalpel structures are anisotropic, magnetic micro- or nanodiscs with high-saturation magnetization and the absence of remanence, facilitating scalpel remote control via the magnetic field. Additionally, anisotropy enhances the transmigration of the discs to the tumor. To date, four types of magnetic microdiscs have been used for tumor destruction: synthetic antiferromagnetic P-SAF (perpendicular) and SAF (in-plane), vortex Py, and three-layer non-magnetic–ferromagnet–non-magnetic systems with flat quasi-dipole magnetic structures. In the current review, we discuss the biological effects of magnetic discs, the mechanisms of action, and the toxicity in alternating or rotating magnetic fields in vitro and in vivo. Based on the experimental data presented in the literature, we conclude that the targeted and remotely controlled magnetic field nanoscalpel is an effective and safe instrument for cancer therapy or theranostics.
Citations by journals
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1
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Journal Physics D: Applied Physics
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1 publication, 16.67%
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International Journal of Molecular Sciences
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1 publication, 16.67%
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Citations by publishers
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1
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IOP Publishing
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IOP Publishing
1 publication, 16.67%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 16.67%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 16.67%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
1 publication, 16.67%
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1
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- Statistics recalculated weekly.
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Zamay T. N. et al. Magnetic Nanodiscs—A New Promising Tool for Microsurgery of Malignant Neoplasms // Nanomaterials. 2021. Vol. 11. No. 6. p. 1459.
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Zamay T. N., Prokopenko V. S., Zamay S. S., Lukyanenko K. A., Kolovskaya O. S., Orlov V. A., Zamay G. S., Galeev R. G., Narodov A. A., Kichkailo A. S. Magnetic Nanodiscs—A New Promising Tool for Microsurgery of Malignant Neoplasms // Nanomaterials. 2021. Vol. 11. No. 6. p. 1459.
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TY - JOUR
DO - 10.3390/nano11061459
UR - https://doi.org/10.3390%2Fnano11061459
TI - Magnetic Nanodiscs—A New Promising Tool for Microsurgery of Malignant Neoplasms
T2 - Nanomaterials
AU - Zamay, Galina S
AU - Kolovskaya, Olga S
AU - Galeev, Rinat G
AU - Narodov, Andrey A
AU - Kichkailo, Anna S.
AU - Zamay, Tatiana N.
AU - Prokopenko, Vladimir S.
AU - Zamay, Sergey S
AU - Lukyanenko, Kirill A.
AU - Orlov, Vitaly A
PY - 2021
DA - 2021/05/31 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1459
IS - 6
VL - 11
PMID - 34072903
SN - 2079-4991
ER -
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@article{2021_Zamay,
author = {Galina S Zamay and Olga S Kolovskaya and Rinat G Galeev and Andrey A Narodov and Anna S. Kichkailo and Tatiana N. Zamay and Vladimir S. Prokopenko and Sergey S Zamay and Kirill A. Lukyanenko and Vitaly A Orlov},
title = {Magnetic Nanodiscs—A New Promising Tool for Microsurgery of Malignant Neoplasms},
journal = {Nanomaterials},
year = {2021},
volume = {11},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {may},
url = {https://doi.org/10.3390%2Fnano11061459},
number = {6},
pages = {1459},
doi = {10.3390/nano11061459}
}
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Zamay, Tatiana N., et al. “Magnetic Nanodiscs—A New Promising Tool for Microsurgery of Malignant Neoplasms.” Nanomaterials, vol. 11, no. 6, May. 2021, p. 1459. https://doi.org/10.3390%2Fnano11061459.