Open Access
Nanomaterials, volume 12, issue 17, pages 3034
The Strong Protective Action of Ce3+/F− Combined Treatment on Tooth Enamel and Epithelial Cells
Popov Anton L.
1, 2
,
Zholobak Nadia M.
3
,
Kolmanovich Danil D.
1, 2
,
Ermakov Artem M.
2, 4
,
Popova Nelli R.
2
,
Chukavin Nikita N.
2, 4
,
Bazikyan Ernest A.
5
,
3
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv 03680, Ukraine
|
Publication type: Journal Article
Publication date: 2022-09-01
PubMed ID:
36080071
General Chemical Engineering
General Materials Science
Abstract
We studied the toxic effects of cerium and fluoride species on human dental pulp stem cells and epithelial cells of Cercopithecus aethiops as a surrogate for the human oral mucosa. The sequential use of CeCl3 and NH4F solutions in equimolar sub-toxic concentrations enabled the possible toxic effects of individual components to be avoided, ensuring the preservation of the metabolic activity of the cells due to the formation of CeF3 nanoparticles. Cerium fluoride nanoparticles and terbium-doped cerium fluoride nanoparticles exhibited neither cytotoxicity nor genotoxicity to dental pulp stem cells, even at high concentrations (10−4 M). In millimolar concentrations (from 10−5–10−6 M), these nanoparticles significantly increased the expression of genes responsible for the cell cycle, differentiation and proliferation. The formation of cerium fluoride on the surface of the mucous membrane and teeth provided protection against the development of carious lesions, periodontitis, ROS attacks and other inflammatory diseases of the oral cavity. Luminescent CeF3: Tb nanoparticles enabled the visualization of tooth enamel microcracks.
Citations by journals
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1
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 33.33%
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Biomedicines
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Biomedicines
1 publication, 33.33%
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Toxicology Mechanisms and Methods
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Toxicology Mechanisms and Methods
1 publication, 33.33%
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1
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Citations by publishers
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1
2
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 66.67%
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Taylor & Francis
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Taylor & Francis
1 publication, 33.33%
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1
2
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Popov A. L. et al. The Strong Protective Action of Ce3+/F− Combined Treatment on Tooth Enamel and Epithelial Cells // Nanomaterials. 2022. Vol. 12. No. 17. p. 3034.
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Popov A. L., Zholobak N. M., Shcherbakov A. B., Kozlova T. O., Kolmanovich D. D., Ermakov A. M., Popova N. R., Chukavin N. N., Bazikyan E. A., Ivanov V. K. The Strong Protective Action of Ce3+/F− Combined Treatment on Tooth Enamel and Epithelial Cells // Nanomaterials. 2022. Vol. 12. No. 17. p. 3034.
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TY - JOUR
DO - 10.3390/nano12173034
UR - https://doi.org/10.3390%2Fnano12173034
TI - The Strong Protective Action of Ce3+/F− Combined Treatment on Tooth Enamel and Epithelial Cells
T2 - Nanomaterials
AU - Zholobak, Nadia M.
AU - Kolmanovich, Danil D.
AU - Popova, Nelli R.
AU - Bazikyan, Ernest A.
AU - Popov, Anton L.
AU - Shcherbakov, Alexander B.
AU - Kozlova, Taisiya O.
AU - Ermakov, Artem M.
AU - Chukavin, Nikita N.
AU - Ivanov, Vladimir K.
PY - 2022
DA - 2022/09/01 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 3034
IS - 17
VL - 12
PMID - 36080071
SN - 2079-4991
ER -
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BibTex
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@article{2022_Popov,
author = {Nadia M. Zholobak and Danil D. Kolmanovich and Nelli R. Popova and Ernest A. Bazikyan and Anton L. Popov and Alexander B. Shcherbakov and Taisiya O. Kozlova and Artem M. Ermakov and Nikita N. Chukavin and Vladimir K. Ivanov},
title = {The Strong Protective Action of Ce3+/F− Combined Treatment on Tooth Enamel and Epithelial Cells},
journal = {Nanomaterials},
year = {2022},
volume = {12},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {sep},
url = {https://doi.org/10.3390%2Fnano12173034},
number = {17},
pages = {3034},
doi = {10.3390/nano12173034}
}
Cite this
MLA
Copy
Popov, Anton L., et al. “The Strong Protective Action of Ce3+/F− Combined Treatment on Tooth Enamel and Epithelial Cells.” Nanomaterials, vol. 12, no. 17, Sep. 2022, p. 3034. https://doi.org/10.3390%2Fnano12173034.