Open Access
Pharmaceutics, volume 10, issue 4, pages 284
HSA—Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer Therapy
Semkina Alevtina
2
,
Naumenko Victor
3
,
Plotnikova Ekaterina
4
,
Yakubovskaya Raisa
4
,
Abakumov Artem
5
,
Majouga Alexander
3, 6, 7
,
Grin Michael
5
,
Chekhonin Vladimir
2
,
Abakumov Maxim
2, 3
Publication type: Journal Article
Publication date: 2018-12-17
PubMed ID:
30562981
Pharmaceutical Science
Abstract
Background: Photodynamic therapy (PDT) is a promising technique for cancer treatment; however, low tissue permeability for irradiating light and insufficient photosensitizer (PS) accumulation in tumors limit its clinical potential. Nanoparticles are engineered to improve selective drug delivery to tumor sites, but its accumulation is highly variable between tumors and patients. Identifying PS accumulation peak in a personalized manner is crucial for therapeutic outcome. Magnetic nanoparticles (MNPs) provide opportunity for tracking drug accumulation in dynamics using non-invasive magnetic resonance imaging (MRI). The purpose of the study was to evaluate MNP loaded with PS as a theranostic tool for treating cancer in mice xenograft colon cancer models. Methods: MNPs coated with human serum albumin (HSA) were loaded with bacteriochlorine a. MRI, atomic emission spectroscopy (AES) and fluorescent imaging were used to study MNP and drug accumulation rates and dynamics in CT26 tumors. Tumor growth curves were evaluated in animals that received PDT at different time points upon MNP systemic injection. Results: Peak MNP accumulation in tumors was detected by MRI 60 min post injection (pi) and the data were verified by AES and fluorescent imaging. Up to 17% of injected dose/g of tissue was delivered to malignant tissues 24 h after injection. Consistent with MRI predicted drug accumulation peak PDT performed 60 min after intravenous injection was more efficient in inhibiting tumor growth than treatment scheduled 30 min and 240 min pi. Conclusions: PS loading on HAS-coated MNPs is a perspective approach to increase drug delivery to tumor site. Tracking for MNP accumulation by MRI can be used to predict drug concentration peak in tumors and to adjust PDT time scheduling for improved antitumor response.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Ostroverkhov P. et al. HSA—Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer Therapy // Pharmaceutics. 2018. Vol. 10. No. 4. p. 284.
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Ostroverkhov P., Semkina A., Naumenko V., Plotnikova E., Yakubovskaya R., Vodopyanov S., Abakumov A., Majouga A., Grin M., Chekhonin V., Abakumov M. HSA—Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer Therapy // Pharmaceutics. 2018. Vol. 10. No. 4. p. 284.
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TY - JOUR
DO - 10.3390/pharmaceutics10040284
UR - https://doi.org/10.3390%2Fpharmaceutics10040284
TI - HSA—Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer Therapy
T2 - Pharmaceutics
AU - Semkina, Alevtina
AU - Naumenko, Victor
AU - Abakumov, Artem
AU - Chekhonin, Vladimir
AU - Abakumov, Maxim
AU - Plotnikova, Ekaterina
AU - Yakubovskaya, Raisa
AU - Majouga, Alexander
AU - Grin, Michael
AU - Vodopyanov, Stepan
AU - Ostroverkhov, Petr
PY - 2018
DA - 2018/12/17 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 284
IS - 4
VL - 10
PMID - 30562981
SN - 1999-4923
ER -
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@article{2018_Ostroverkhov,
author = {Alevtina Semkina and Victor Naumenko and Artem Abakumov and Vladimir Chekhonin and Maxim Abakumov and Ekaterina Plotnikova and Raisa Yakubovskaya and Alexander Majouga and Michael Grin and Stepan Vodopyanov and Petr Ostroverkhov},
title = {HSA—Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer Therapy},
journal = {Pharmaceutics},
year = {2018},
volume = {10},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {dec},
url = {https://doi.org/10.3390%2Fpharmaceutics10040284},
number = {4},
pages = {284},
doi = {10.3390/pharmaceutics10040284}
}
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Ostroverkhov, Petr, et al. “HSA—Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer Therapy.” Pharmaceutics, vol. 10, no. 4, Dec. 2018, p. 284. https://doi.org/10.3390%2Fpharmaceutics10040284.