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Polymers, volume 15, issue 15, pages 3167

Development of Nonwoven Fibrous Materials Based on Poly-3-Hydroxybutyrate with a High Content of α-Tricalcium Phosphate

Kristina G. Gasparyan 1, 2
Alexander Yu Fedotov 3
Pavel V. Lobzhanidze 3
Oleg V. Baranov 3
Alexey A. Egorov 3
Vladimir P Sirotinkin 3
Vladimir S. Komlev 3
Show full list: 9 authors
Publication typeJournal Article
Publication date2023-07-26
Journal: Polymers
scimago Q1
wos Q1
SJR0.800
CiteScore8.0
Impact factor4.7
ISSN20734360
General Chemistry
Polymers and Plastics
Abstract

α-tricalcium (α-TCP) phosphate is widely used as an osteoinductive biocompatible material, serving as an alternative to synthetic porous bone materials. The objective of this study is to obtain a highly filled fibrous nonwoven material composed of poly-3-hydroxybutyrate (PHB) and α-TCP and to investigate the morphology, structure, and properties of the composite obtained by the electrospinning method (ES). The addition of α-TCP had a significant effect on the supramolecular structure of the material, allowing it to control the crystallinity of the material, which was accompanied by changes in mechanical properties, FTIR spectra, and XRD curves. The obtained results open the way to the creation of new osteoconductive materials with a controlled release of the source of calcium into the living organism.

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