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MDPI
Technologies
,  volume 11 ,  issue 3 ,  pages 77

Injectable Hydrated Calcium Phosphate Bone-like Paste: Synthesis, In Vitro, and In Vivo Biocompatibility Assessment

Anastasia Yu. Teterina 1
, 
Vladislav V. Minaychev 1, 2
, 
Polina V. Smirnova 1
, 
M I Kobyakova 1, 2
, 
Igor V. Smirnov 1
, 
Roman S. Fadeev 2
, 
Alexey A. Egorov 1
, 
Artem A Ashmarin 1
, 
Kira V. Pyatina 2
, 
Anatoliy S. Senotov 2
, 
Irina S. Fadeeva 1, 2
, 
Vladimir S. Komlev 1
1
 
2
 
Publication type: Journal Article
Publication date: 2023-06-15
MDPI
scimago Q1
wos Q1
SJR: 0.880
CiteScore: 8.5
Impact factor: 3.6
ISSN: 22277080
Computer Science (miscellaneous)
Abstract

The injectable hydrated calcium phosphate bone-like paste (hCPP) was developed with suitable rheological characteristics, enabling unhindered injection through standard 23G needles. In vitro assays showed the cytocompatibility of hCPP with mesenchymal embryonic C3H10T1/2 cell cultures. The hCPP was composed of aggregated micro-sized particles with sphere-like shapes and low crystallinity. The ability of hCPP particles to adsorb serum proteins (FBS) was investigated. The hCPP demonstrated high protein adsorption capacity, indicating its potential in various biomedical applications. The results of the in vivo assay upon subcutaneous injection in Wistar rats indicated nontoxicity and biocompatibility of experimental hCPP, as well as gradual resorption of hCPP, comparable to the period of bone regeneration. The data obtained are of great interest for the development of commercial highly effective osteoplastic materials for bone tissue regeneration and augmentation.

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Teterina A. Y. et al. Injectable Hydrated Calcium Phosphate Bone-like Paste: Synthesis, In Vitro, and In Vivo Biocompatibility Assessment // Technologies. 2023. Vol. 11. No. 3. p. 77.
GOST all authors (up to 50) Copy
Teterina A. Y., Minaychev V. V., Smirnova P. V., Kobyakova M. I., Smirnov I. V., Fadeev R. S., Egorov A. A., Ashmarin A. A., Pyatina K. V., Senotov A. S., Fadeeva I. S., Komlev V. S. Injectable Hydrated Calcium Phosphate Bone-like Paste: Synthesis, In Vitro, and In Vivo Biocompatibility Assessment // Technologies. 2023. Vol. 11. No. 3. p. 77.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3390/technologies11030077
UR - https://doi.org/10.3390/technologies11030077
TI - Injectable Hydrated Calcium Phosphate Bone-like Paste: Synthesis, In Vitro, and In Vivo Biocompatibility Assessment
T2 - Technologies
AU - Teterina, Anastasia Yu.
AU - Minaychev, Vladislav V.
AU - Smirnova, Polina V.
AU - Kobyakova, M I
AU - Smirnov, Igor V.
AU - Fadeev, Roman S.
AU - Egorov, Alexey A.
AU - Ashmarin, Artem A
AU - Pyatina, Kira V.
AU - Senotov, Anatoliy S.
AU - Fadeeva, Irina S.
AU - Komlev, Vladimir S.
PY - 2023
DA - 2023/06/15
PB - MDPI
SP - 77
IS - 3
VL - 11
SN - 2227-7080
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Teterina,
author = {Anastasia Yu. Teterina and Vladislav V. Minaychev and Polina V. Smirnova and M I Kobyakova and Igor V. Smirnov and Roman S. Fadeev and Alexey A. Egorov and Artem A Ashmarin and Kira V. Pyatina and Anatoliy S. Senotov and Irina S. Fadeeva and Vladimir S. Komlev},
title = {Injectable Hydrated Calcium Phosphate Bone-like Paste: Synthesis, In Vitro, and In Vivo Biocompatibility Assessment},
journal = {Technologies},
year = {2023},
volume = {11},
publisher = {MDPI},
month = {jun},
url = {https://doi.org/10.3390/technologies11030077},
number = {3},
pages = {77},
doi = {10.3390/technologies11030077}
}
MLA
Cite this
MLA Copy
Teterina, Anastasia Yu., et al. “Injectable Hydrated Calcium Phosphate Bone-like Paste: Synthesis, In Vitro, and In Vivo Biocompatibility Assessment.” Technologies, vol. 11, no. 3, Jun. 2023, p. 77. https://doi.org/10.3390/technologies11030077.