Open Access
Viruses, volume 14, issue 4, pages 831
Two Novel Lytic Bacteriophages Infecting Enterococcus spp. Are Promising Candidates for Targeted Antibacterial Therapy
Tkachev Pavel V
1
,
Pchelin Ivan M
1
,
Azarov Daniil V
1
,
Gorshkov Andrey Nikolaevich
2, 3
,
Shamova Olga V
1
,
Dmitriev Alexander V
1
,
Publication type: Journal Article
Publication date: 2022-04-16
PubMed ID:
35458561
Infectious Diseases
Virology
Abstract
The rapid emergence of antibiotic resistance is of major concern globally. Among the most worrying pathogenic bacteria are vancomycin-resistant enterococci. Phage therapy is a highly promising method for controlling enterococcal infections. In this study, we described two virulent tailed bacteriophages possessing lytic activity against Enterococcus faecalis and E. faecium isolates. The SSsP-1 bacteriophage belonged to the Saphexavirus genus of the Siphoviridae family, and the GVEsP-1 bacteriophage belonged to the Schiekvirus genus of Herelleviridae. The genomes of both viruses carried putative components of anti-CRISPR systems and did not contain known genes coding for antibiotic-resistance determinants and virulence factors. The conservative arrangement of protein-coding sequences in Saphexavirus and Schiekvirus genomes taken together with positive results of treating enterococcal peritonitis in an animal infection model imply the potential suitability of GVEsP-1 and SSsP-1 bacteriophages for clinical applications.
Citations by journals
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1
2
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Viruses
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Viruses
2 publications, 25%
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Microorganisms
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Microorganisms
1 publication, 12.5%
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Antibiotics
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Antibiotics
1 publication, 12.5%
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Russian Journal for Personalized Medicine
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Russian Journal for Personalized Medicine
1 publication, 12.5%
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Microbiology spectrum
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Microbiology spectrum
1 publication, 12.5%
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Journal of Pharmaceutical Sciences
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Journal of Pharmaceutical Sciences
1 publication, 12.5%
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1
2
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Citations by publishers
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1
2
3
4
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 50%
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|
Almazov National Medical Research Centre
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Almazov National Medical Research Centre
1 publication, 12.5%
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American Society for Microbiology
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American Society for Microbiology
1 publication, 12.5%
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Elsevier
|
Elsevier
1 publication, 12.5%
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Springer Nature
|
Springer Nature
1 publication, 12.5%
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1
2
3
4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Tkachev P. V. et al. Two Novel Lytic Bacteriophages Infecting Enterococcus spp. Are Promising Candidates for Targeted Antibacterial Therapy // Viruses. 2022. Vol. 14. No. 4. p. 831.
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Tkachev P. V., Pchelin I. M., Azarov D. V., Gorshkov A. N., Shamova O. V., Dmitriev A. V., Goncharov A. E. Two Novel Lytic Bacteriophages Infecting Enterococcus spp. Are Promising Candidates for Targeted Antibacterial Therapy // Viruses. 2022. Vol. 14. No. 4. p. 831.
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TY - JOUR
DO - 10.3390/v14040831
UR - https://doi.org/10.3390%2Fv14040831
TI - Two Novel Lytic Bacteriophages Infecting Enterococcus spp. Are Promising Candidates for Targeted Antibacterial Therapy
T2 - Viruses
AU - Azarov, Daniil V
AU - Shamova, Olga V
AU - Dmitriev, Alexander V
AU - Tkachev, Pavel V
AU - Pchelin, Ivan M
AU - Gorshkov, Andrey Nikolaevich
AU - Goncharov, Artemiy E.
PY - 2022
DA - 2022/04/16 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 831
IS - 4
VL - 14
PMID - 35458561
SN - 1999-4915
ER -
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BibTex
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@article{2022_Tkachev,
author = {Daniil V Azarov and Olga V Shamova and Alexander V Dmitriev and Pavel V Tkachev and Ivan M Pchelin and Andrey Nikolaevich Gorshkov and Artemiy E. Goncharov},
title = {Two Novel Lytic Bacteriophages Infecting Enterococcus spp. Are Promising Candidates for Targeted Antibacterial Therapy},
journal = {Viruses},
year = {2022},
volume = {14},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {apr},
url = {https://doi.org/10.3390%2Fv14040831},
number = {4},
pages = {831},
doi = {10.3390/v14040831}
}
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MLA
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Tkachev, Pavel V., et al. “Two Novel Lytic Bacteriophages Infecting Enterococcus spp. Are Promising Candidates for Targeted Antibacterial Therapy.” Viruses, vol. 14, no. 4, Apr. 2022, p. 831. https://doi.org/10.3390%2Fv14040831.