Open Access
Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1- Position
1
Chemistry Department, Faculty of Science-Girls College 838, Dammam 31113, Saudi Arabia
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Publication type: Journal Article
Publication date: 2001-06-30
DOI:
10.3390/60700621
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Novel 1-[6-(p-tolyl) pyridazin-3-yl]pyrazole-o-aminonitriles (3a-c) were formed using 3-hydrazino-6-(p-tolyl)pyridazine (2) and ketene S,S-acetals (1a), S,N-acetals (1b) or tetracyanoethylene (1c). The pyrazole-o-aminonitriles (3a-c) were in turn used as precursors for the preparation of previously unreported 1-[6-(p-tolyl)-pyridazin-3-yl]pyrazolo[3,4-d]pyrimidines (8, 9, 13-20) and 7-[6-( p-tolyl) pyridazin-3-yl]2-arylpyrazolo[3,4-d]1,2,4-triazolo[5,1-f]pyrimidines (10-12) which are expected to possess considerable chemical and pharmacological activities.
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35
Total citations:
35
Citations from 2025:
1
(2.86%)
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MLA
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GOST
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Al Afaleq E., Abubshait S. Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1- Position // Molecules. 2001. Vol. 6. No. 7. pp. 621-638.
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Al Afaleq E., Abubshait S. Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1- Position // Molecules. 2001. Vol. 6. No. 7. pp. 621-638.
Cite this
RIS
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TY - JOUR
DO - 10.3390/60700621
UR - https://doi.org/10.3390/60700621
TI - Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1- Position
T2 - Molecules
AU - Al Afaleq, Eljazi
AU - Abubshait, Samar
PY - 2001
DA - 2001/06/30
PB - MDPI
SP - 621-638
IS - 7
VL - 6
SN - 1420-3049
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2001_Al Afaleq,
author = {Eljazi Al Afaleq and Samar Abubshait},
title = {Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1- Position},
journal = {Molecules},
year = {2001},
volume = {6},
publisher = {MDPI},
month = {jun},
url = {https://doi.org/10.3390/60700621},
number = {7},
pages = {621--638},
doi = {10.3390/60700621}
}
Cite this
MLA
Copy
Al Afaleq, Eljazi, and Samar Abubshait. “Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1- Position.” Molecules, vol. 6, no. 7, Jun. 2001, pp. 621-638. https://doi.org/10.3390/60700621.