Open Access
International Journal of Molecular Sciences, volume 24, issue 9, pages 8269
SARS-CoV-2 Binding and Neutralization Properties of Peptides Derived from N-Terminus of Human ACE2
Irina V Astrakhantseva
1
,
Alina E. Ershova
1
,
Sergei A Chuvpilo
1
,
Aydar A Ishmukhametov
3, 4
,
Marina S. Drutskaya
5
,
Liubov I Kozlovskaya
3, 4
,
Sergei A. Nedospasov
1, 5
Publication type: Journal Article
Publication date: 2023-05-05
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
The binding properties of synthetic and recombinant peptides derived from N-terminal part of ACE2, the main receptor for SARS-CoV-2, were evaluated. Additionally, the ability of these peptides to prevent virus entry in vitro was addressed using both pseudovirus particles decorated with the S protein, as well as through infection of Vero cells with live SARS-CoV-2 virus. Surprisingly, in spite of effective binding to S protein, all linear peptides of various lengths failed to neutralize the viral infection in vitro. However, the P1st peptide that was chemically “stapled” in order to stabilize its alpha-helical structure was able to interfere with virus entry into ACE2-expressing cells. Interestingly, this peptide also neutralized pseudovirus particles decorated with S protein derived from the Omicron BA.1 virus, in spite of variations in key amino acid residues contacting ACE2.
Top-30
Citations by journals
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1
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Computers in Biology and Medicine
1 publication, 33.33%
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International Journal of Molecular Sciences
1 publication, 33.33%
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Russian Chemical Reviews
1 publication, 33.33%
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1
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Citations by publishers
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1
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Elsevier
1 publication, 33.33%
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 33.33%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 33.33%
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1
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Astrakhantseva I. V. et al. SARS-CoV-2 Binding and Neutralization Properties of Peptides Derived from N-Terminus of Human ACE2 // International Journal of Molecular Sciences. 2023. Vol. 24. No. 9. p. 8269.
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Astrakhantseva I. V., Ershova A. E., Chuvpilo S. A., Kruglova N. S., Ishmukhametov A. A., Drutskaya M. S., Kozlovskaya L., Nedospasov S. A. SARS-CoV-2 Binding and Neutralization Properties of Peptides Derived from N-Terminus of Human ACE2 // International Journal of Molecular Sciences. 2023. Vol. 24. No. 9. p. 8269.
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TY - JOUR
DO - 10.3390/ijms24098269
UR - https://doi.org/10.3390/ijms24098269
TI - SARS-CoV-2 Binding and Neutralization Properties of Peptides Derived from N-Terminus of Human ACE2
T2 - International Journal of Molecular Sciences
AU - Astrakhantseva, Irina V
AU - Ershova, Alina E.
AU - Chuvpilo, Sergei A
AU - Kruglova, Natal’ya S.
AU - Ishmukhametov, Aydar A
AU - Drutskaya, Marina S.
AU - Kozlovskaya, Liubov I
AU - Nedospasov, Sergei A.
PY - 2023
DA - 2023/05/05 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 8269
IS - 9
VL - 24
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2023_Astrakhantseva,
author = {Irina V Astrakhantseva and Alina E. Ershova and Sergei A Chuvpilo and Natal’ya S. Kruglova and Aydar A Ishmukhametov and Marina S. Drutskaya and Liubov I Kozlovskaya and Sergei A. Nedospasov},
title = {SARS-CoV-2 Binding and Neutralization Properties of Peptides Derived from N-Terminus of Human ACE2},
journal = {International Journal of Molecular Sciences},
year = {2023},
volume = {24},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {may},
url = {https://doi.org/10.3390/ijms24098269},
number = {9},
pages = {8269},
doi = {10.3390/ijms24098269}
}
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Astrakhantseva, Irina V., et al. “SARS-CoV-2 Binding and Neutralization Properties of Peptides Derived from N-Terminus of Human ACE2.” International Journal of Molecular Sciences, vol. 24, no. 9, May. 2023, p. 8269. https://doi.org/10.3390/ijms24098269.
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