Open Access
Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic Acids and Evaluation of Cytotoxic Activity of the Products
Тип публикации: Journal Article
Дата публикации: 2021-12-22
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Краткое описание
2-Aryl-2-(3-indolyl)acetohydroxamic acids demonstrate promising antitumor activity, but quickly metabolize in vivo via glucuronidation of hydroxamic acid residue. In an attempt to improve their pharmacokinetics, methyl esters were synthesized via a newly developed protocol for chemoselective mono-methylation of hydroxamic acids. The cytotoxicity of these derivatives against the HeLa cell line was evaluated and found to be inferior compared to the parent lead compounds.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Топ-30
Журналы
|
1
|
|
|
Molecules
1 публикация, 33.33%
|
|
|
Russian Chemical Reviews
1 публикация, 33.33%
|
|
|
Russian Journal of General Chemistry
1 публикация, 33.33%
|
|
|
1
|
Издатели
|
1
|
|
|
MDPI
1 публикация, 33.33%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 публикация, 33.33%
|
|
|
Pleiades Publishing
1 публикация, 33.33%
|
|
|
1
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.
Вы ученый?
Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Метрики
3
Всего цитирований:
3
Цитирований c 2025:
1
(33.33%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Aksenov D. A. et al. Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic Acids and Evaluation of Cytotoxic Activity of the Products // MolBank. 2021. Vol. 2022. No. 1. p. M1307.
ГОСТ со всеми авторами (до 50)
Скопировать
Aksenov D. A., Aksenov A., Prityko L. A., Aksenov N. A., Frolova L. V., Rubin M. Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic Acids and Evaluation of Cytotoxic Activity of the Products // MolBank. 2021. Vol. 2022. No. 1. p. M1307.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.3390/m1307
UR - https://doi.org/10.3390/m1307
TI - Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic Acids and Evaluation of Cytotoxic Activity of the Products
T2 - MolBank
AU - Aksenov, Dmitrii A
AU - Aksenov, Alexander V.
AU - Prityko, Lidiya A
AU - Aksenov, Nicolai A.
AU - Frolova, Liliya V
AU - Rubin, Michael
PY - 2021
DA - 2021/12/22
PB - MDPI
SP - M1307
IS - 1
VL - 2022
SN - 1422-8599
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2021_Aksenov,
author = {Dmitrii A Aksenov and Alexander V. Aksenov and Lidiya A Prityko and Nicolai A. Aksenov and Liliya V Frolova and Michael Rubin},
title = {Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic Acids and Evaluation of Cytotoxic Activity of the Products},
journal = {MolBank},
year = {2021},
volume = {2022},
publisher = {MDPI},
month = {dec},
url = {https://doi.org/10.3390/m1307},
number = {1},
pages = {M1307},
doi = {10.3390/m1307}
}
Цитировать
MLA
Скопировать
Aksenov, Dmitrii A., et al. “Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic Acids and Evaluation of Cytotoxic Activity of the Products.” MolBank, vol. 2022, no. 1, Dec. 2021, p. M1307. https://doi.org/10.3390/m1307.
Лаборатории
Профили