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,  volume 2022 ,  issue 1 ,  pages M1307

Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic Acids and Evaluation of Cytotoxic Activity of the Products

Publication type: Journal Article
Publication date: 2021-12-22
MDPI
scimago Q4
wos Q4
SJR: 0.142
CiteScore: 0.9
Impact factor: 0.4
ISSN: 14228599
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract

2-Aryl-2-(3-indolyl)acetohydroxamic acids demonstrate promising antitumor activity, but quickly metabolize in vivo via glucuronidation of hydroxamic acid residue. In an attempt to improve their pharmacokinetics, methyl esters were synthesized via a newly developed protocol for chemoselective mono-methylation of hydroxamic acids. The cytotoxicity of these derivatives against the HeLa cell line was evaluated and found to be inferior compared to the parent lead compounds.

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Aksenov Aleksandr
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GOST |
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GOST Copy
Aksenov D. A. et al. Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic Acids and Evaluation of Cytotoxic Activity of the Products // MolBank. 2021. Vol. 2022. No. 1. p. M1307.
GOST all authors (up to 50) Copy
Aksenov D. A., Aksenov A., Prityko L. A., Aksenov N. A., Frolova L. V., Rubin M. Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic Acids and Evaluation of Cytotoxic Activity of the Products // MolBank. 2021. Vol. 2022. No. 1. p. M1307.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.3390/m1307
UR - https://doi.org/10.3390/m1307
TI - Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic Acids and Evaluation of Cytotoxic Activity of the Products
T2 - MolBank
AU - Aksenov, Dmitrii A
AU - Aksenov, Alexander V.
AU - Prityko, Lidiya A
AU - Aksenov, Nicolai A.
AU - Frolova, Liliya V
AU - Rubin, Michael
PY - 2021
DA - 2021/12/22
PB - MDPI
SP - M1307
IS - 1
VL - 2022
SN - 1422-8599
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2021_Aksenov,
author = {Dmitrii A Aksenov and Alexander V. Aksenov and Lidiya A Prityko and Nicolai A. Aksenov and Liliya V Frolova and Michael Rubin},
title = {Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic Acids and Evaluation of Cytotoxic Activity of the Products},
journal = {MolBank},
year = {2021},
volume = {2022},
publisher = {MDPI},
month = {dec},
url = {https://doi.org/10.3390/m1307},
number = {1},
pages = {M1307},
doi = {10.3390/m1307}
}
MLA
Cite this
MLA Copy
Aksenov, Dmitrii A., et al. “Methylation of 2-Aryl-2-(3-indolyl)acetohydroxamic Acids and Evaluation of Cytotoxic Activity of the Products.” MolBank, vol. 2022, no. 1, Dec. 2021, p. M1307. https://doi.org/10.3390/m1307.