Open Access
A Novel Disulfide-Containing Polycationic Amphiphile: 1,28-Di[(cholest-5-en-3β-yl)disulfanyl]-4,25-dioxo-3,8,12,17,21,26-hexaazaoctacosane Tetrahydrochloride
Pavel A Puchkov
1
,
Elena V Shmendel
1
,
Valeria D Andreeva
1
,
Nina G. Morozova
1
,
Marina A Zenkova
2
,
Mikhail A Maslov
1
,
Publication type: Journal Article
Publication date: 2018-02-18
DOI:
10.3390/M981
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
The absence of highly effective delivery systems is a major challenge for gene therapy. Our work was aimed at the development of novel cationic liposomes possessing high transfection efficiency. For this purpose, a novel disulfide polycationic amphiphile 2S4 was synthesized. Cationic liposomes based on 2S4 and a helper lipid DOPE were formed by the thin film hydration method and exhibited effective plasmid DNA delivery into the HEK293 cells, with a transfection activity superior to that of the commercial agent Lipofectamine® 2000. Our results suggest that the polycationic amphiphile 2S4 is a promising candidate for in vitro nucleic acid delivery.
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Puchkov P. A. et al. A Novel Disulfide-Containing Polycationic Amphiphile: 1,28-Di[(cholest-5-en-3β-yl)disulfanyl]-4,25-dioxo-3,8,12,17,21,26-hexaazaoctacosane Tetrahydrochloride // MolBank. 2018. Vol. 2018. No. 1. p. M981.
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Puchkov P. A., Shmendel E. V., Andreeva V. D., Morozova N. G., Zenkova M. A., Maslov M. A., Maslov M. A Novel Disulfide-Containing Polycationic Amphiphile: 1,28-Di[(cholest-5-en-3β-yl)disulfanyl]-4,25-dioxo-3,8,12,17,21,26-hexaazaoctacosane Tetrahydrochloride // MolBank. 2018. Vol. 2018. No. 1. p. M981.
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TY - JOUR
DO - 10.3390/M981
UR - https://www.mdpi.com/1422-8599/2018/1/M981
TI - A Novel Disulfide-Containing Polycationic Amphiphile: 1,28-Di[(cholest-5-en-3β-yl)disulfanyl]-4,25-dioxo-3,8,12,17,21,26-hexaazaoctacosane Tetrahydrochloride
T2 - MolBank
AU - Puchkov, Pavel A
AU - Shmendel, Elena V
AU - Andreeva, Valeria D
AU - Morozova, Nina G.
AU - Zenkova, Marina A
AU - Maslov, Mikhail A
AU - Maslov, Michael
PY - 2018
DA - 2018/02/18
PB - MDPI
SP - M981
IS - 1
VL - 2018
SN - 1422-8599
ER -
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@article{2018_Puchkov,
author = {Pavel A Puchkov and Elena V Shmendel and Valeria D Andreeva and Nina G. Morozova and Marina A Zenkova and Mikhail A Maslov and Michael Maslov},
title = {A Novel Disulfide-Containing Polycationic Amphiphile: 1,28-Di[(cholest-5-en-3β-yl)disulfanyl]-4,25-dioxo-3,8,12,17,21,26-hexaazaoctacosane Tetrahydrochloride},
journal = {MolBank},
year = {2018},
volume = {2018},
publisher = {MDPI},
month = {feb},
url = {https://www.mdpi.com/1422-8599/2018/1/M981},
number = {1},
pages = {M981},
doi = {10.3390/M981}
}
Cite this
MLA
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Puchkov, Pavel A., et al. “A Novel Disulfide-Containing Polycationic Amphiphile: 1,28-Di[(cholest-5-en-3β-yl)disulfanyl]-4,25-dioxo-3,8,12,17,21,26-hexaazaoctacosane Tetrahydrochloride.” MolBank, vol. 2018, no. 1, Feb. 2018, p. M981. https://www.mdpi.com/1422-8599/2018/1/M981.
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