Open Access
Asperindoles A-D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp KMM 4676
Elena Ivanets
1
,
Anton Yurchenko
1
,
Olga Smetanina
1
,
Anton Rasin
1
,
Olesya Zhuravleva
1, 2
,
Mikhail Pivkin
1
,
Roman Popov
1
,
Gunhild von Amsberg
3
,
Shamil Afiyatullov
1
,
Sergey A. Dyshlovoy
1, 2, 3
Publication type: Journal Article
Publication date: 2018-07-09
PubMed ID:
29987238
Drug Discovery
Pharmaceutical Science
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Abstract
Four new indole-diterpene alkaloids asperindoles A–D (1–4) and the known p-terphenyl derivative 3″-hydroxyterphenyllin (5) were isolated from the marine-derived strain of the fungus Aspergillus sp., associated with an unidentified colonial ascidian. The structures of 1–5 were established by 2D NMR and HRESIMS data. The absolute configurations of all stereocenters of 1–4 were determined by the combination of ROESY data, coupling constants analysis, and biogenetic considerations. Asperindoles C and D contain a 2-hydroxyisobutyric acid (2-HIBA) residue, rarely found in natural compounds. Asperindole A exhibits cytotoxic activity against hormone therapy-resistant PC-3 and 22Rv1, as well as hormone therapy-sensitive human prostate cancer cells, and induces apoptosis in these cells at low-micromolar concentrations.
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45
Total citations:
45
Citations from 2024:
5
(11%)
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GOST
Copy
Ivanets E. et al. Asperindoles A-D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp KMM 4676 // Marine Drugs. 2018. Vol. 16. No. 7. p. 232.
GOST all authors (up to 50)
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Ivanets E., Yurchenko A., Smetanina O., Rasin A., Zhuravleva O., Pivkin M., Popov R., von Amsberg G., Afiyatullov S., Dyshlovoy S. A. Asperindoles A-D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp KMM 4676 // Marine Drugs. 2018. Vol. 16. No. 7. p. 232.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/MD16070232
UR - https://doi.org/10.3390/MD16070232
TI - Asperindoles A-D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp KMM 4676
T2 - Marine Drugs
AU - Ivanets, Elena
AU - Yurchenko, Anton
AU - Smetanina, Olga
AU - Rasin, Anton
AU - Zhuravleva, Olesya
AU - Pivkin, Mikhail
AU - Popov, Roman
AU - von Amsberg, Gunhild
AU - Afiyatullov, Shamil
AU - Dyshlovoy, Sergey A.
PY - 2018
DA - 2018/07/09
PB - MDPI
SP - 232
IS - 7
VL - 16
PMID - 29987238
SN - 1660-3397
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Ivanets,
author = {Elena Ivanets and Anton Yurchenko and Olga Smetanina and Anton Rasin and Olesya Zhuravleva and Mikhail Pivkin and Roman Popov and Gunhild von Amsberg and Shamil Afiyatullov and Sergey A. Dyshlovoy},
title = {Asperindoles A-D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp KMM 4676},
journal = {Marine Drugs},
year = {2018},
volume = {16},
publisher = {MDPI},
month = {jul},
url = {https://doi.org/10.3390/MD16070232},
number = {7},
pages = {232},
doi = {10.3390/MD16070232}
}
Cite this
MLA
Copy
Ivanets, Elena, et al. “Asperindoles A-D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp KMM 4676.” Marine Drugs, vol. 16, no. 7, Jul. 2018, p. 232. https://doi.org/10.3390/MD16070232.