Open Access
Marine Drugs, volume 16, issue 7, pages 232
Asperindoles A-D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp KMM 4676
Ivanets Elena
1
,
Yurchenko Anton
1
,
Smetanina Olga
1
,
Rasin Anton
1
,
Zhuravleva Olesya
1, 2
,
Pivkin Mikhail
1
,
Popov Roman
1
,
von Amsberg Gunhild
3
,
Afiyatullov Shamil
1
,
Dyshlovoy Sergey A.
1, 2, 3
3
Laboratory of Experimental Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
|
Publication type: Journal Article
Publication date: 2018-07-09
PubMed ID:
29987238
Drug Discovery
Pharmaceutical Science
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Abstract
Four new indole-diterpene alkaloids asperindoles A–D (1–4) and the known p-terphenyl derivative 3″-hydroxyterphenyllin (5) were isolated from the marine-derived strain of the fungus Aspergillus sp., associated with an unidentified colonial ascidian. The structures of 1–5 were established by 2D NMR and HRESIMS data. The absolute configurations of all stereocenters of 1–4 were determined by the combination of ROESY data, coupling constants analysis, and biogenetic considerations. Asperindoles C and D contain a 2-hydroxyisobutyric acid (2-HIBA) residue, rarely found in natural compounds. Asperindole A exhibits cytotoxic activity against hormone therapy-resistant PC-3 and 22Rv1, as well as hormone therapy-sensitive human prostate cancer cells, and induces apoptosis in these cells at low-micromolar concentrations.
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Citations by publishers
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1 publication, 2.44%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Ivanets E. et al. Asperindoles A-D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp KMM 4676 // Marine Drugs. 2018. Vol. 16. No. 7. p. 232.
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Ivanets E., Yurchenko A., Smetanina O., Rasin A., Zhuravleva O., Pivkin M., Popov R., von Amsberg G., Afiyatullov S., Dyshlovoy S. A. Asperindoles A-D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp KMM 4676 // Marine Drugs. 2018. Vol. 16. No. 7. p. 232.
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TY - JOUR
DO - 10.3390/MD16070232
UR - https://doi.org/10.3390%2FMD16070232
TI - Asperindoles A-D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp KMM 4676
T2 - Marine Drugs
AU - Yurchenko, Anton
AU - Smetanina, Olga
AU - Rasin, Anton
AU - Popov, Roman
AU - von Amsberg, Gunhild
AU - Ivanets, Elena
AU - Zhuravleva, Olesya
AU - Pivkin, Mikhail
AU - Afiyatullov, Shamil
AU - Dyshlovoy, Sergey A.
PY - 2018
DA - 2018/07/09 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 232
IS - 7
VL - 16
PMID - 29987238
SN - 1660-3397
ER -
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@article{2018_Ivanets,
author = {Anton Yurchenko and Olga Smetanina and Anton Rasin and Roman Popov and Gunhild von Amsberg and Elena Ivanets and Olesya Zhuravleva and Mikhail Pivkin and Shamil Afiyatullov and Sergey A. Dyshlovoy},
title = {Asperindoles A-D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp KMM 4676},
journal = {Marine Drugs},
year = {2018},
volume = {16},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jul},
url = {https://doi.org/10.3390%2FMD16070232},
number = {7},
pages = {232},
doi = {10.3390/MD16070232}
}
Cite this
MLA
Copy
Ivanets, Elena, et al. “Asperindoles A-D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp KMM 4676.” Marine Drugs, vol. 16, no. 7, Jul. 2018, p. 232. https://doi.org/10.3390%2FMD16070232.