Open Access
Asperindoles A-D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp KMM 4676
Тип публикации: Journal Article
Дата публикации: 2018-07-09
scimago Q1
wos Q1
БС1
SJR: 1.030
CiteScore: 10.1
Impact factor: 5.4
ISSN: 16603397
PubMed ID:
29987238
Drug Discovery
Pharmaceutical Science
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Краткое описание
Four new indole-diterpene alkaloids asperindoles A–D (1–4) and the known p-terphenyl derivative 3″-hydroxyterphenyllin (5) were isolated from the marine-derived strain of the fungus Aspergillus sp., associated with an unidentified colonial ascidian. The structures of 1–5 were established by 2D NMR and HRESIMS data. The absolute configurations of all stereocenters of 1–4 were determined by the combination of ROESY data, coupling constants analysis, and biogenetic considerations. Asperindoles C and D contain a 2-hydroxyisobutyric acid (2-HIBA) residue, rarely found in natural compounds. Asperindole A exhibits cytotoxic activity against hormone therapy-resistant PC-3 and 22Rv1, as well as hormone therapy-sensitive human prostate cancer cells, and induces apoptosis in these cells at low-micromolar concentrations.
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ГОСТ
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Ivanets E. et al. Asperindoles A-D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp KMM 4676 // Marine Drugs. 2018. Vol. 16. No. 7. p. 232.
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Ivanets E., Yurchenko A., Smetanina O., Rasin A., Zhuravleva O., Pivkin M., Popov R., von Amsberg G., Afiyatullov S., Dyshlovoy S. A. Asperindoles A-D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp KMM 4676 // Marine Drugs. 2018. Vol. 16. No. 7. p. 232.
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RIS
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TY - JOUR
DO - 10.3390/MD16070232
UR - https://doi.org/10.3390/MD16070232
TI - Asperindoles A-D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp KMM 4676
T2 - Marine Drugs
AU - Ivanets, Elena
AU - Yurchenko, Anton
AU - Smetanina, Olga
AU - Rasin, Anton
AU - Zhuravleva, Olesya
AU - Pivkin, Mikhail
AU - Popov, Roman
AU - von Amsberg, Gunhild
AU - Afiyatullov, Shamil
AU - Dyshlovoy, Sergey A.
PY - 2018
DA - 2018/07/09
PB - MDPI
SP - 232
IS - 7
VL - 16
PMID - 29987238
SN - 1660-3397
ER -
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BibTex (до 50 авторов)
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@article{2018_Ivanets,
author = {Elena Ivanets and Anton Yurchenko and Olga Smetanina and Anton Rasin and Olesya Zhuravleva and Mikhail Pivkin and Roman Popov and Gunhild von Amsberg and Shamil Afiyatullov and Sergey A. Dyshlovoy},
title = {Asperindoles A-D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp KMM 4676},
journal = {Marine Drugs},
year = {2018},
volume = {16},
publisher = {MDPI},
month = {jul},
url = {https://doi.org/10.3390/MD16070232},
number = {7},
pages = {232},
doi = {10.3390/MD16070232}
}
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MLA
Скопировать
Ivanets, Elena, et al. “Asperindoles A-D and a p-Terphenyl Derivative from the Ascidian-Derived Fungus Aspergillus sp KMM 4676.” Marine Drugs, vol. 16, no. 7, Jul. 2018, p. 232. https://doi.org/10.3390/MD16070232.