Open Access
Marine Drugs, volume 16, issue 11, pages 457
Neuroprotective Activity of Some Marine Fungal Metabolites in the 6-Hydroxydopamin- and Paraquat-Induced Parkinson's Disease Models
Menchinskaya Ekaterina
1
,
Pislyagin E.A.
1
,
Trinh Phan
2, 3
,
Ivanets Elena
4
,
Smetanina Olga
4
,
Publication type: Journal Article
Publication date: 2018-11-21
PubMed ID:
30469376
Drug Discovery
Pharmaceutical Science
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Abstract
A new melatonin analogue 6-hydroxy-N-acetyl-β-oxotryptamine (1) was isolated from the marine-derived fungus Penicillium sp. KMM 4672. It is the second case of melatonin-related compounds isolation from microfilamentous fungi. The neuroprotective activities of this metabolite, as well as 3-methylorsellinic acid (2) and 8-methoxy-3,5-dimethylisochroman-6-ol (3) from Penicillium sp. KMM 4672, candidusin A (4) and 4″-dehydroxycandidusin A (5) from Aspergillus sp. KMM 4676, and diketopiperazine mactanamide (6) from Aspergillus flocculosus, were investigated in the 6-hydroxydopamine (6-OHDA)- and paraquat (PQ)-induced Parkinson’s disease (PD) cell models. All of them protected Neuro2a cells against the damaging influence of 6-OHDA to varying degrees. This effect may be realized via a reactive oxygen species (ROS) scavenging pathway. The new melatonin analogue more effectively protected Neuro2A cells against the 6-OHDA-induced neuronal death, in comparison with melatonin, as well as against the PQ-induced neurotoxicity. Dehydroxylation at C-3″ and C-4″ significantly increased free radical scavenging and neuroprotective activity of candidusin-related p-terphenyl polyketides in both the 6-OHDA- and PQ-induced PD models.
Citations by journals
|
1
2
3
4
5
|
|
|
Marine Drugs
|
Marine Drugs
5 publications, 17.24%
|
|
International Journal of Molecular Sciences
|
International Journal of Molecular Sciences
4 publications, 13.79%
|
|
Molecules
|
Molecules
3 publications, 10.34%
|
|
RSC Advances
|
RSC Advances
2 publications, 6.9%
|
|
Biomedicines
|
Biomedicines
1 publication, 3.45%
|
|
Journal of Fungi
|
Journal of Fungi
1 publication, 3.45%
|
|
Phytochemistry
|
Phytochemistry
1 publication, 3.45%
|
|
PLoS ONE
|
PLoS ONE
1 publication, 3.45%
|
|
Marine Life Science & Technology
|
Marine Life Science & Technology
1 publication, 3.45%
|
|
Pharmacological Research
|
Pharmacological Research
1 publication, 3.45%
|
|
Chinese Journal of Chemistry
|
Chinese Journal of Chemistry
1 publication, 3.45%
|
|
Brazilian Journal of Microbiology
|
Brazilian Journal of Microbiology
1 publication, 3.45%
|
|
Natural Product Reports
|
Natural Product Reports
1 publication, 3.45%
|
|
CNS and Neurological Disorders - Drug Targets
|
CNS and Neurological Disorders - Drug Targets
1 publication, 3.45%
|
|
Oxygen
|
Oxygen
1 publication, 3.45%
|
|
Metabolites
|
Metabolites
1 publication, 3.45%
|
|
Neurodegenerative disease management
|
Neurodegenerative disease management
1 publication, 3.45%
|
|
1
2
3
4
5
|
Citations by publishers
|
2
4
6
8
10
12
14
16
|
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
16 publications, 55.17%
|
|
Royal Society of Chemistry (RSC)
|
Royal Society of Chemistry (RSC)
3 publications, 10.34%
|
|
Elsevier
|
Elsevier
2 publications, 6.9%
|
|
Springer Nature
|
Springer Nature
2 publications, 6.9%
|
|
Public Library of Science (PLoS)
|
Public Library of Science (PLoS)
1 publication, 3.45%
|
|
Wiley
|
Wiley
1 publication, 3.45%
|
|
Bentham Science
|
Bentham Science
1 publication, 3.45%
|
|
Future Medicine
|
Future Medicine
1 publication, 3.45%
|
|
2
4
6
8
10
12
14
16
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2019,2020,2021,2022,2023],"ids":[0,0,0,0,0],"codes":[0,0,0,0,0],"imageUrls":["","","","",""],"datasets":[{"label":"Citations number","data":[4,4,9,4,8],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["13.79","13.79","31.03","13.79","27.59"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Marine Drugs","International Journal of Molecular Sciences","Molecules","RSC Advances","Biomedicines","Journal of Fungi","Phytochemistry","PLoS ONE","Marine Life Science & Technology","Pharmacological Research","Chinese Journal of Chemistry","Brazilian Journal of Microbiology","Natural Product Reports","CNS and Neurological Disorders - Drug Targets","Oxygen","Metabolites","Neurodegenerative disease management"],"ids":[23709,14627,1770,3100,24421,3021,2920,24963,29210,4321,7222,16977,15252,1046,29084,17024,17656],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/AN2jnDN59NmKaS4CWLHAGstADL2DbnatQScsFA6C_medium.webp"],"datasets":[{"label":"","data":[5,4,3,2,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[17.24,13.79,10.34,6.9,3.45,3.45,3.45,3.45,3.45,3.45,3.45,3.45,3.45,3.45,3.45,3.45,3.45],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Multidisciplinary Digital Publishing Institute (MDPI)","Royal Society of Chemistry (RSC)","Elsevier","Springer Nature","Public Library of Science (PLoS)","Wiley","Bentham Science","Future Medicine"],"ids":[202,123,17,8,344,11,39,6949],"codes":[0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/AN2jnDN59NmKaS4CWLHAGstADL2DbnatQScsFA6C_medium.webp"],"datasets":[{"label":"","data":[16,3,2,2,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[55.17,10.34,6.9,6.9,3.45,3.45,3.45,3.45],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Yurchenko E. et al. Neuroprotective Activity of Some Marine Fungal Metabolites in the 6-Hydroxydopamin- and Paraquat-Induced Parkinson's Disease Models // Marine Drugs. 2018. Vol. 16. No. 11. p. 457.
GOST all authors (up to 50)
Copy
Yurchenko E., Menchinskaya E., Pislyagin E., Trinh P., Ivanets E., Smetanina O., Yurchenko A. Neuroprotective Activity of Some Marine Fungal Metabolites in the 6-Hydroxydopamin- and Paraquat-Induced Parkinson's Disease Models // Marine Drugs. 2018. Vol. 16. No. 11. p. 457.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/MD16110457
UR - https://doi.org/10.3390%2FMD16110457
TI - Neuroprotective Activity of Some Marine Fungal Metabolites in the 6-Hydroxydopamin- and Paraquat-Induced Parkinson's Disease Models
T2 - Marine Drugs
AU - Yurchenko, Ekaterina
AU - Menchinskaya, Ekaterina
AU - Smetanina, Olga
AU - Yurchenko, Anton
AU - Trinh, Phan
AU - Ivanets, Elena
AU - Pislyagin, E.A.
PY - 2018
DA - 2018/11/21 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 457
IS - 11
VL - 16
PMID - 30469376
SN - 1660-3397
ER -
Cite this
BibTex
Copy
@article{2018_Yurchenko,
author = {Ekaterina Yurchenko and Ekaterina Menchinskaya and Olga Smetanina and Anton Yurchenko and Phan Trinh and Elena Ivanets and E.A. Pislyagin},
title = {Neuroprotective Activity of Some Marine Fungal Metabolites in the 6-Hydroxydopamin- and Paraquat-Induced Parkinson's Disease Models},
journal = {Marine Drugs},
year = {2018},
volume = {16},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {nov},
url = {https://doi.org/10.3390%2FMD16110457},
number = {11},
pages = {457},
doi = {10.3390/MD16110457}
}
Cite this
MLA
Copy
Yurchenko, Ekaterina, et al. “Neuroprotective Activity of Some Marine Fungal Metabolites in the 6-Hydroxydopamin- and Paraquat-Induced Parkinson's Disease Models.” Marine Drugs, vol. 16, no. 11, Nov. 2018, p. 457. https://doi.org/10.3390%2FMD16110457.