Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus
Four new compounds were isolated from the Vietnamese marine sediment-derived fungus Aspergillus flocculosus, one aspyrone-related polyketide aspilactonol G (2), one meroterpenoid 12-epi-aspertetranone D (4), two drimane derivatives (7,9), together with five known metabolites (1,3,5,6,8,10). The structures of compounds 1–10 were established by NMR and MS techniques. The absolute stereoconfigurations of compounds 1 and 2 were determined by a modified Mosher’s method. The absolute configurations of compounds 4 and 7 were established by a combination of analysis of ROESY data and coupling constants as well as biogenetic considerations. Compounds 7 and 8 exhibited cytotoxic activity toward human prostate cancer 22Rv1, human breast cancer MCF-7, and murine neuroblastoma Neuro-2a cells.
Citations by journals
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Marine Drugs
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4 publications, 20%
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Molecules
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3 publications, 15%
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1 publication, 5%
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Journal of Fungi
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Journal of Fungi
1 publication, 5%
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Frontiers in Chemistry
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Frontiers in Chemistry
1 publication, 5%
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Phytochemistry
1 publication, 5%
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World Journal of Microbiology and Biotechnology
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World Journal of Microbiology and Biotechnology
1 publication, 5%
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Brazilian Journal of Microbiology
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Brazilian Journal of Microbiology
1 publication, 5%
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Angewandte Chemie
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Angewandte Chemie
1 publication, 5%
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Angewandte Chemie - International Edition
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Angewandte Chemie - International Edition
1 publication, 5%
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Organic and Biomolecular Chemistry
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Organic and Biomolecular Chemistry
1 publication, 5%
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Natural Product Reports
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Natural Product Reports
1 publication, 5%
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Handbook of Research on Trends in the Diagnosis and Treatment of Chronic Conditions
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Handbook of Research on Trends in the Diagnosis and Treatment of Chronic Conditions
1 publication, 5%
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Chemistry and Biodiversity
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Chemistry and Biodiversity
1 publication, 5%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
8 publications, 40%
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Wiley
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Wiley
3 publications, 15%
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Springer Nature
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Springer Nature
2 publications, 10%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
2 publications, 10%
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Bentham Science
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Bentham Science
1 publication, 5%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 5%
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Elsevier
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Elsevier
1 publication, 5%
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IGI Global
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IGI Global
1 publication, 5%
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