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Marine Drugs, volume 17, issue 10, pages 579

Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus

Girich (ivanets) Elena 1
Smetanina Olga 1
Rasin Anton 1
Popov Roman 1
Dyshlovoy Sergey A. 1, 3, 4, 5
von Amsberg Gunhild 4, 5
Menchinskaya Ekaterina 1
Tran Thanh Van 2
Afiyatullov Shamil 1
4
 
Laboratory of Experimental Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
5
 
Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, 20246 Hamburg, Germany
Publication typeJournal Article
Publication date2019-10-11
Journal: Marine Drugs
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor5.4
ISSN16603397
PubMed ID:  31614563
Drug Discovery
Pharmaceutical Science
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Abstract

Four new compounds were isolated from the Vietnamese marine sediment-derived fungus Aspergillus flocculosus, one aspyrone-related polyketide aspilactonol G (2), one meroterpenoid 12-epi-aspertetranone D (4), two drimane derivatives (7,9), together with five known metabolites (1,3,5,6,8,10). The structures of compounds 1–10 were established by NMR and MS techniques. The absolute stereoconfigurations of compounds 1 and 2 were determined by a modified Mosher’s method. The absolute configurations of compounds 4 and 7 were established by a combination of analysis of ROESY data and coupling constants as well as biogenetic considerations. Compounds 7 and 8 exhibited cytotoxic activity toward human prostate cancer 22Rv1, human breast cancer MCF-7, and murine neuroblastoma Neuro-2a cells.

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GOST Copy
Yurchenko A. N. et al. Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus // Marine Drugs. 2019. Vol. 17. No. 10. p. 579.
GOST all authors (up to 50) Copy
Yurchenko A. N., Trinh P. T. H., Girich (ivanets) E., Smetanina O., Rasin A., Popov R., Dyshlovoy S. A., von Amsberg G., Menchinskaya E., Tran T. V., Afiyatullov S. Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus // Marine Drugs. 2019. Vol. 17. No. 10. p. 579.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.3390/MD17100579
UR - https://doi.org/10.3390%2FMD17100579
TI - Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus
T2 - Marine Drugs
AU - Smetanina, Olga
AU - Rasin, Anton
AU - Popov, Roman
AU - von Amsberg, Gunhild
AU - Menchinskaya, Ekaterina
AU - Tran, Thanh Van
AU - Girich (ivanets), Elena
AU - Afiyatullov, Shamil
AU - Yurchenko, Anton N
AU - Trinh, Phan Thi Hoai
AU - Dyshlovoy, Sergey A.
PY - 2019
DA - 2019/10/11 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 579
IS - 10
VL - 17
PMID - 31614563
SN - 1660-3397
ER -
BibTex |
Cite this
BibTex Copy
@article{2019_Yurchenko
author = {Olga Smetanina and Anton Rasin and Roman Popov and Gunhild von Amsberg and Ekaterina Menchinskaya and Thanh Van Tran and Elena Girich (ivanets) and Shamil Afiyatullov and Anton N Yurchenko and Phan Thi Hoai Trinh and Sergey A. Dyshlovoy},
title = {Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus},
journal = {Marine Drugs},
year = {2019},
volume = {17},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {oct},
url = {https://doi.org/10.3390%2FMD17100579},
number = {10},
pages = {579},
doi = {10.3390/MD17100579}
}
MLA
Cite this
MLA Copy
Yurchenko, Anton N., et al. “Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus.” Marine Drugs, vol. 17, no. 10, Oct. 2019, p. 579. https://doi.org/10.3390%2FMD17100579.
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