Open Access
Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus
Elena Girich (ivanets)
1
,
Olga Smetanina
1
,
Anton Rasin
1
,
Roman Popov
1
,
Sergey A. Dyshlovoy
1, 3, 4, 5
,
Gunhild von Amsberg
4, 5
,
Ekaterina Menchinskaya
1
,
Thanh Van Tran
2
,
Shamil Afiyatullov
1
Publication type: Journal Article
Publication date: 2019-10-11
PubMed ID:
31614563
Drug Discovery
Pharmaceutical Science
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Abstract
Four new compounds were isolated from the Vietnamese marine sediment-derived fungus Aspergillus flocculosus, one aspyrone-related polyketide aspilactonol G (2), one meroterpenoid 12-epi-aspertetranone D (4), two drimane derivatives (7,9), together with five known metabolites (1,3,5,6,8,10). The structures of compounds 1–10 were established by NMR and MS techniques. The absolute stereoconfigurations of compounds 1 and 2 were determined by a modified Mosher’s method. The absolute configurations of compounds 4 and 7 were established by a combination of analysis of ROESY data and coupling constants as well as biogenetic considerations. Compounds 7 and 8 exhibited cytotoxic activity toward human prostate cancer 22Rv1, human breast cancer MCF-7, and murine neuroblastoma Neuro-2a cells.
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Total citations:
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Citations from 2024:
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(24%)
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MLA
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GOST
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Yurchenko A. N. et al. Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus // Marine Drugs. 2019. Vol. 17. No. 10. p. 579.
GOST all authors (up to 50)
Copy
Yurchenko A. N., Trinh P. T. H., Girich (ivanets) E., Smetanina O., Rasin A., Popov R., Dyshlovoy S. A., von Amsberg G., Menchinskaya E., Tran T. V., Afiyatullov S. Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus // Marine Drugs. 2019. Vol. 17. No. 10. p. 579.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/MD17100579
UR - https://doi.org/10.3390/MD17100579
TI - Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus
T2 - Marine Drugs
AU - Yurchenko, Anton N
AU - Trinh, Phan Thi Hoai
AU - Girich (ivanets), Elena
AU - Smetanina, Olga
AU - Rasin, Anton
AU - Popov, Roman
AU - Dyshlovoy, Sergey A.
AU - von Amsberg, Gunhild
AU - Menchinskaya, Ekaterina
AU - Tran, Thanh Van
AU - Afiyatullov, Shamil
PY - 2019
DA - 2019/10/11
PB - MDPI
SP - 579
IS - 10
VL - 17
PMID - 31614563
SN - 1660-3397
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Yurchenko,
author = {Anton N Yurchenko and Phan Thi Hoai Trinh and Elena Girich (ivanets) and Olga Smetanina and Anton Rasin and Roman Popov and Sergey A. Dyshlovoy and Gunhild von Amsberg and Ekaterina Menchinskaya and Thanh Van Tran and Shamil Afiyatullov},
title = {Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus},
journal = {Marine Drugs},
year = {2019},
volume = {17},
publisher = {MDPI},
month = {oct},
url = {https://doi.org/10.3390/MD17100579},
number = {10},
pages = {579},
doi = {10.3390/MD17100579}
}
Cite this
MLA
Copy
Yurchenko, Anton N., et al. “Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus.” Marine Drugs, vol. 17, no. 10, Oct. 2019, p. 579. https://doi.org/10.3390/MD17100579.