Open Access
Open access
Marine Drugs, volume 18, issue 12, pages 608

Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera

Publication typeJournal Article
Publication date2020-11-30
Journal: Marine Drugs
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor5.4
ISSN16603397
PubMed ID:  33266016
Drug Discovery
Pharmaceutical Science
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Abstract

Low molecular weight secondary metabolites of marine fungi Aspergillus flocculosus, Aspergillus terreus and Penicillium sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds were determined by 1D and 2D NMR and HR-ESI-MS techniques. Stereochemistry of some compounds was established based on ECD data. A chemical structure of asterriquinone F (6) was thoroughly described for the first time. Anthraquinone (13) was firstly obtained from a natural source. Neuroprotective influences of the isolated compounds against 6-OHDA, paraquat and rotenone toxicity were investigated. 4-Hydroxyscytalone (1), 4-hydroxy-6-dehydroxyscytalone (2) and demethylcitreoviranol (3) have shown significant increasing of paraquat- and rotenone-treated Neuro-2a cell viability and anti-ROS activity.

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Girich E. V. et al. Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera // Marine Drugs. 2020. Vol. 18. No. 12. p. 608.
GOST all authors (up to 50) Copy
Girich E. V., Yurchenko A. N., Smetanina O. F., Trinh P. T. H., Ngoc N. T. D., Pivkin M. V., Popov R. S., Pislyagin E., Menchinskaya E. S., Chingizova E. A., Afiyatullov S. S., YURCHENKO E. Y. Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera // Marine Drugs. 2020. Vol. 18. No. 12. p. 608.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3390/MD18120608
UR - https://doi.org/10.3390%2FMD18120608
TI - Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera
T2 - Marine Drugs
AU - Smetanina, Olga F
AU - Ngoc, Ngo Thi Duy
AU - Pivkin, Mikhail V
AU - Popov, Roman S
AU - Menchinskaya, Ekaterina S
AU - Chingizova, Ekaterina A
AU - Afiyatullov, Shamil S
AU - Girich, Elena V
AU - Yurchenko, Anton N
AU - Trinh, Phan Thi Hoai
AU - Pislyagin, E.A.
AU - YURCHENKO, EKATERINA Y.
PY - 2020
DA - 2020/11/30 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 608
IS - 12
VL - 18
PMID - 33266016
SN - 1660-3397
ER -
BibTex |
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BibTex Copy
@article{2020_Girich,
author = {Olga F Smetanina and Ngo Thi Duy Ngoc and Mikhail V Pivkin and Roman S Popov and Ekaterina S Menchinskaya and Ekaterina A Chingizova and Shamil S Afiyatullov and Elena V Girich and Anton N Yurchenko and Phan Thi Hoai Trinh and E.A. Pislyagin and EKATERINA Y. YURCHENKO},
title = {Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera},
journal = {Marine Drugs},
year = {2020},
volume = {18},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {nov},
url = {https://doi.org/10.3390%2FMD18120608},
number = {12},
pages = {608},
doi = {10.3390/MD18120608}
}
MLA
Cite this
MLA Copy
Girich, Elena V., et al. “Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera.” Marine Drugs, vol. 18, no. 12, Nov. 2020, p. 608. https://doi.org/10.3390%2FMD18120608.
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