Open Access
Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera
Elena V Girich
1
,
Olga F Smetanina
1
,
Ngo Thi Duy Ngoc
2
,
Mikhail V Pivkin
1
,
Roman S Popov
1
,
E.A. Pislyagin
1
,
Ekaterina S Menchinskaya
1
,
Shamil S Afiyatullov
1
,
Publication type: Journal Article
Publication date: 2020-11-30
PubMed ID:
33266016
Drug Discovery
Pharmaceutical Science
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Abstract
Low molecular weight secondary metabolites of marine fungi Aspergillus flocculosus, Aspergillus terreus and Penicillium sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds were determined by 1D and 2D NMR and HR-ESI-MS techniques. Stereochemistry of some compounds was established based on ECD data. A chemical structure of asterriquinone F (6) was thoroughly described for the first time. Anthraquinone (13) was firstly obtained from a natural source. Neuroprotective influences of the isolated compounds against 6-OHDA, paraquat and rotenone toxicity were investigated. 4-Hydroxyscytalone (1), 4-hydroxy-6-dehydroxyscytalone (2) and demethylcitreoviranol (3) have shown significant increasing of paraquat- and rotenone-treated Neuro-2a cell viability and anti-ROS activity.
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Metrics
28
Total citations:
28
Citations from 2024:
8
(28%)
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MLA
Cite this
GOST
Copy
Girich E. V. et al. Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera // Marine Drugs. 2020. Vol. 18. No. 12. p. 608.
GOST all authors (up to 50)
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Girich E. V., Yurchenko A. N., Smetanina O. F., Trinh P. T. H., Ngoc N. T. D., Pivkin M. V., Popov R. S., Pislyagin E., Menchinskaya E. S., Chingizova E. A., Afiyatullov S. S., YURCHENKO E. Y. Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera // Marine Drugs. 2020. Vol. 18. No. 12. p. 608.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/MD18120608
UR - https://www.mdpi.com/1660-3397/18/12/608
TI - Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera
T2 - Marine Drugs
AU - Girich, Elena V
AU - Yurchenko, Anton N
AU - Smetanina, Olga F
AU - Trinh, Phan Thi Hoai
AU - Ngoc, Ngo Thi Duy
AU - Pivkin, Mikhail V
AU - Popov, Roman S
AU - Pislyagin, E.A.
AU - Menchinskaya, Ekaterina S
AU - Chingizova, Ekaterina A
AU - Afiyatullov, Shamil S
AU - YURCHENKO, EKATERINA Y.
PY - 2020
DA - 2020/11/30
PB - MDPI
SP - 608
IS - 12
VL - 18
PMID - 33266016
SN - 1660-3397
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Girich,
author = {Elena V Girich and Anton N Yurchenko and Olga F Smetanina and Phan Thi Hoai Trinh and Ngo Thi Duy Ngoc and Mikhail V Pivkin and Roman S Popov and E.A. Pislyagin and Ekaterina S Menchinskaya and Ekaterina A Chingizova and Shamil S Afiyatullov and EKATERINA Y. YURCHENKO},
title = {Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera},
journal = {Marine Drugs},
year = {2020},
volume = {18},
publisher = {MDPI},
month = {nov},
url = {https://www.mdpi.com/1660-3397/18/12/608},
number = {12},
pages = {608},
doi = {10.3390/MD18120608}
}
Cite this
MLA
Copy
Girich, Elena V., et al. “Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera.” Marine Drugs, vol. 18, no. 12, Nov. 2020, p. 608. https://www.mdpi.com/1660-3397/18/12/608.