Open Access
Molecules, volume 25, issue 1, pages 61
Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus
Smetanina Olga F
1
,
Girich (ivanets) Elena V
1
,
Antonov Alexander S
1
,
Dyshlovoy Sergey A.
1, 3, 4, 5
,
von Amsberg Gunhild
3, 4
,
Kim Natalya Y
1
,
Chingizova Ekaterina A
1
,
Pislyagin E.A.
1
,
Menchinskaya Ekaterina S
1
,
Van Tran Thi Thanh
2
,
Afiyatullov Shamil S
1
3
Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, 20246 Hamburg, Germany
|
4
Laboratory of Experimental Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
|
Publication type: Journal Article
Publication date: 2019-12-23
PubMed ID:
31878044
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Seven known echinulin-related indolediketopiperazine alkaloids (1–7) were isolated from the Vietnamese sediment-derived fungus Aspergillus niveoglaucus. Using chiral HPLC, the enantiomers of cryptoechinuline B (1) were isolated as individual compounds for the first time. (+)-Cryptoechinuline B (1a) exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson’s disease. (−)-Cryptoechinuline B (1b) and neoechinulin C (5) protected the neuronal cells against paraquat-induced damage in a Parkinson’s disease model. Neoechinulin B (4) exhibited cytoprotective activity in a rotenone-induced model, and neoechinulin (7) showed activity in the 6-OHDA-induced model.
Citations by journals
1
2
3
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|
Marine Drugs
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Marine Drugs
3 publications, 27.27%
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Molecules
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Molecules
2 publications, 18.18%
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Plants
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Plants
1 publication, 9.09%
|
Biomolecules
|
Biomolecules
1 publication, 9.09%
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Brazilian Journal of Microbiology
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Brazilian Journal of Microbiology
1 publication, 9.09%
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Journal of Agricultural and Food Chemistry
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Journal of Agricultural and Food Chemistry
1 publication, 9.09%
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RSC Advances
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RSC Advances
1 publication, 9.09%
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Neurodegenerative disease management
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Neurodegenerative disease management
1 publication, 9.09%
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1
2
3
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Citations by publishers
1
2
3
4
5
6
7
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
7 publications, 63.64%
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Springer Nature
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Springer Nature
1 publication, 9.09%
|
American Chemical Society (ACS)
|
American Chemical Society (ACS)
1 publication, 9.09%
|
Royal Society of Chemistry (RSC)
|
Royal Society of Chemistry (RSC)
1 publication, 9.09%
|
Future Medicine
|
Future Medicine
1 publication, 9.09%
|
1
2
3
4
5
6
7
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Smetanina O. F. et al. Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus // Molecules. 2019. Vol. 25. No. 1. p. 61.
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Smetanina O. F., Yurchenko A. N., Girich (ivanets) E. V., Trinh P. T. H., Antonov A. S., Dyshlovoy S. A., von Amsberg G., Kim N. Y., Chingizova E. A., Pislyagin E., Menchinskaya E. S., YURCHENKO E. Y., Van T. T. T., Afiyatullov S. S. Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus // Molecules. 2019. Vol. 25. No. 1. p. 61.
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TY - JOUR
DO - 10.3390/MOLECULES25010061
UR - https://doi.org/10.3390%2FMOLECULES25010061
TI - Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus
T2 - Molecules
AU - Smetanina, Olga F
AU - Girich (ivanets), Elena V
AU - Antonov, Alexander S
AU - von Amsberg, Gunhild
AU - Kim, Natalya Y
AU - Chingizova, Ekaterina A
AU - Menchinskaya, Ekaterina S
AU - Van, Tran Thi Thanh
AU - Afiyatullov, Shamil S
AU - Yurchenko, Anton N
AU - Trinh, Phan Thi Hoai
AU - Dyshlovoy, Sergey A.
AU - Pislyagin, E.A.
AU - YURCHENKO, EKATERINA Y.
PY - 2019
DA - 2019/12/23 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 61
IS - 1
VL - 25
PMID - 31878044
SN - 1420-3049
ER -
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@article{2019_Smetanina,
author = {Olga F Smetanina and Elena V Girich (ivanets) and Alexander S Antonov and Gunhild von Amsberg and Natalya Y Kim and Ekaterina A Chingizova and Ekaterina S Menchinskaya and Tran Thi Thanh Van and Shamil S Afiyatullov and Anton N Yurchenko and Phan Thi Hoai Trinh and Sergey A. Dyshlovoy and E.A. Pislyagin and EKATERINA Y. YURCHENKO},
title = {Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus},
journal = {Molecules},
year = {2019},
volume = {25},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {dec},
url = {https://doi.org/10.3390%2FMOLECULES25010061},
number = {1},
pages = {61},
doi = {10.3390/MOLECULES25010061}
}
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Smetanina, Olga F., et al. “Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus.” Molecules, vol. 25, no. 1, Dec. 2019, p. 61. https://doi.org/10.3390%2FMOLECULES25010061.