Open Access
Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus
Тип публикации: Journal Article
Дата публикации: 2019-12-23
PubMed ID:
31878044
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Краткое описание
Seven known echinulin-related indolediketopiperazine alkaloids (1–7) were isolated from the Vietnamese sediment-derived fungus Aspergillus niveoglaucus. Using chiral HPLC, the enantiomers of cryptoechinuline B (1) were isolated as individual compounds for the first time. (+)-Cryptoechinuline B (1a) exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson’s disease. (−)-Cryptoechinuline B (1b) and neoechinulin C (5) protected the neuronal cells against paraquat-induced damage in a Parkinson’s disease model. Neoechinulin B (4) exhibited cytoprotective activity in a rotenone-induced model, and neoechinulin (7) showed activity in the 6-OHDA-induced model.
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ГОСТ
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Smetanina O. F. et al. Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus // Molecules. 2019. Vol. 25. No. 1. p. 61.
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Smetanina O. F., Yurchenko A. N., Girich (ivanets) E. V., Trinh P. T. H., Antonov A. S., Dyshlovoy S. A., von Amsberg G., Kim N. Y., Chingizova E. A., Pislyagin E., Menchinskaya E. S., YURCHENKO E. Y., Van T. T. T., Afiyatullov S. S. Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus // Molecules. 2019. Vol. 25. No. 1. p. 61.
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TY - JOUR
DO - 10.3390/MOLECULES25010061
UR - https://www.mdpi.com/1420-3049/25/1/61
TI - Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus
T2 - Molecules
AU - Smetanina, Olga F
AU - Yurchenko, Anton N
AU - Girich (ivanets), Elena V
AU - Trinh, Phan Thi Hoai
AU - Antonov, Alexander S
AU - Dyshlovoy, Sergey A.
AU - von Amsberg, Gunhild
AU - Kim, Natalya Y
AU - Chingizova, Ekaterina A
AU - Pislyagin, E.A.
AU - Menchinskaya, Ekaterina S
AU - YURCHENKO, EKATERINA Y.
AU - Van, Tran Thi Thanh
AU - Afiyatullov, Shamil S
PY - 2019
DA - 2019/12/23
PB - MDPI
SP - 61
IS - 1
VL - 25
PMID - 31878044
SN - 1420-3049
ER -
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@article{2019_Smetanina,
author = {Olga F Smetanina and Anton N Yurchenko and Elena V Girich (ivanets) and Phan Thi Hoai Trinh and Alexander S Antonov and Sergey A. Dyshlovoy and Gunhild von Amsberg and Natalya Y Kim and Ekaterina A Chingizova and E.A. Pislyagin and Ekaterina S Menchinskaya and EKATERINA Y. YURCHENKO and Tran Thi Thanh Van and Shamil S Afiyatullov},
title = {Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus},
journal = {Molecules},
year = {2019},
volume = {25},
publisher = {MDPI},
month = {dec},
url = {https://www.mdpi.com/1420-3049/25/1/61},
number = {1},
pages = {61},
doi = {10.3390/MOLECULES25010061}
}
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MLA
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Smetanina, Olga F., et al. “Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus.” Molecules, vol. 25, no. 1, Dec. 2019, p. 61. https://www.mdpi.com/1420-3049/25/1/61.
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