Open Access
Molecules, volume 26, issue 12, pages 3618
Cytoprotective Activity of p-Terphenyl Polyketides and Flavuside B from Marine-Derived Fungi against Oxidative Stress in Neuro-2a Cells
Menchinskaya Ekaterina S
1
,
Pislyagin E.A.
1
,
Chingizova Ekaterina A
1
,
Girich Elena V
2
,
Aminin Dmitry L.
1, 3
,
Mikhailov Valery V.
4
Publication type: Journal Article
Publication date: 2021-06-13
PubMed ID:
34199157
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
The influence of p-terphenyl polyketides 1–3 from Aspergillus candidus KMM 4676 and cerebroside flavuside B (4) from Penicillium islandicum (=Talaromyces islandicus) against the effect of neurotoxins, rotenone and paraquat, on Neuro-2a cell viability by MTT and LDH release assays and intracellular ROS level, as well as DPPH radical scavenging activity, was investigated. Pre-incubation with compounds significantly diminished the ROS level in rotenone- and paraquat-treated cells. It was shown that the investigated polyketides 1–3 significantly increased the viability of rotenone- and paraquat-treated cells in two of the used assays but they affected only the viability of paraquat-treated cells in the LDH release assay. Flavuside B statistically increased the viability of paraquat-treated cells in both MTT and LDH release assays, however, it increased the viability of rotenone-treated cells in the LDH release assay. Structure–activity relationships for p-terphenyl derivatives, as well as possible mechanisms of cytoprotective action of all studied compounds, were discussed.
Citations by journals
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1
2
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Marine Drugs
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Marine Drugs
2 publications, 28.57%
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Bioorganic and Medicinal Chemistry
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Bioorganic and Medicinal Chemistry
1 publication, 14.29%
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Molecules
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Molecules
1 publication, 14.29%
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Dyes and Pigments
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Dyes and Pigments
1 publication, 14.29%
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Oxygen
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Oxygen
1 publication, 14.29%
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1
2
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Citations by publishers
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1
2
3
4
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 57.14%
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Elsevier
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Elsevier
2 publications, 28.57%
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|
1
2
3
4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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YURCHENKO E. Y. et al. Cytoprotective Activity of p-Terphenyl Polyketides and Flavuside B from Marine-Derived Fungi against Oxidative Stress in Neuro-2a Cells // Molecules. 2021. Vol. 26. No. 12. p. 3618.
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YURCHENKO E. Y., Menchinskaya E. S., Pislyagin E., Chingizova E. A., Girich E. V., Yurchenko A. N., Aminin D. L., Mikhailov V. V. Cytoprotective Activity of p-Terphenyl Polyketides and Flavuside B from Marine-Derived Fungi against Oxidative Stress in Neuro-2a Cells // Molecules. 2021. Vol. 26. No. 12. p. 3618.
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TY - JOUR
DO - 10.3390/MOLECULES26123618
UR - https://doi.org/10.3390%2FMOLECULES26123618
TI - Cytoprotective Activity of p-Terphenyl Polyketides and Flavuside B from Marine-Derived Fungi against Oxidative Stress in Neuro-2a Cells
T2 - Molecules
AU - Girich, Elena V
AU - Aminin, Dmitry L.
AU - Mikhailov, Valery V.
AU - Menchinskaya, Ekaterina S
AU - Chingizova, Ekaterina A
AU - YURCHENKO, EKATERINA Y.
AU - Pislyagin, E.A.
AU - Yurchenko, Anton N
PY - 2021
DA - 2021/06/13 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 3618
IS - 12
VL - 26
PMID - 34199157
SN - 1420-3049
ER -
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@article{2021_YURCHENKO,
author = {Elena V Girich and Dmitry L. Aminin and Valery V. Mikhailov and Ekaterina S Menchinskaya and Ekaterina A Chingizova and EKATERINA Y. YURCHENKO and E.A. Pislyagin and Anton N Yurchenko},
title = {Cytoprotective Activity of p-Terphenyl Polyketides and Flavuside B from Marine-Derived Fungi against Oxidative Stress in Neuro-2a Cells},
journal = {Molecules},
year = {2021},
volume = {26},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jun},
url = {https://doi.org/10.3390%2FMOLECULES26123618},
number = {12},
pages = {3618},
doi = {10.3390/MOLECULES26123618}
}
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YURCHENKO, EKATERINA Y., et al. “Cytoprotective Activity of p-Terphenyl Polyketides and Flavuside B from Marine-Derived Fungi against Oxidative Stress in Neuro-2a Cells.” Molecules, vol. 26, no. 12, Jun. 2021, p. 3618. https://doi.org/10.3390%2FMOLECULES26123618.