Acta Microbiologica Hellenica, volume 69, issue 3, pages 180-186

Anti-HIV Activity of Philippine Crocodile (Crocodylus mindorensis) Serum on Infected Human Mononuclear Cells

Alfredo A Hinay 1, 2
Nelyn Mae T. Cadotdot 1
Marilou V. Tablizo 3
Aprilyn F. Francisco 1
1
 
College of Medical and Biological Sciences, University of the Immaculate Conception, Davao City 8000, Philippines
2
 
Graduate School Department, University of the Immaculate Conception, Davao City 8000, Philippines
3
 
Science Resource Center, University of the Immaculate Conception, Davao City 8000, Philippines
Publication typeJournal Article
Publication date2024-08-07
scimago Q4
SJR0.108
CiteScore0.2
Impact factor
ISSN04389573, 24594113, 28139054
Abstract

The search for effective inhibitors of HIV-1 replication remains a critical research area of research in virology and immunology. Natural products have emerged as promising candidates for antiviral therapies. In the present study, we assessed the potential inhibitory activity of Philippine crocodile serum at both pre- and post-infection stages of the HIV-1 replication cycle. Freshly collected crocodile serum samples were used in a cell culture-based assay with peripheral blood mononuclear cells. HIV-1 reverse transcriptase activity in the treated cell culture system was assessed using colorimetric enzyme immunoassay. The crocodile serum at 0.5% and 0.25% vol/vol concentrations showed an inhibitory activity against HIV-1 replication both in pre-infection interactions (68.61 ± 1.67% and 69.95 ± 2.24%, respectively) and post-infection interactions (65.68 ± 2.93% and 69.92 ± 0.45%, respective). These findings suggest that Philippine crocodile serum may have potential as a natural inhibitor of HIV-1 replication and warrant further investigation into its therapeutic use.

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