Open Access
Antibiotics, volume 9, issue 1, pages 17
More Than a Pore: A Current Perspective on the In Vivo Mode of Action of the Lipopeptide Antibiotic Daptomycin
1
Newcastle University Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
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Publication type: Journal Article
Publication date: 2020-01-03
PubMed ID:
31947747
Biochemistry
Microbiology (medical)
Microbiology
Infectious Diseases
Pharmacology (medical)
General Pharmacology, Toxicology and Pharmaceutics
Abstract
Daptomycin is a cyclic lipopeptide antibiotic, which was discovered in 1987 and entered the market in 2003. To date, it serves as last resort antibiotic to treat complicated skin infections, bacteremia, and right-sided endocarditis caused by Gram-positive pathogens, most prominently methicillin-resistant Staphylococcus aureus. Daptomycin was the last representative of a novel antibiotic class that was introduced to the clinic. It is also one of the few membrane-active compounds that can be applied systemically. While membrane-active antibiotics have long been limited to topical applications and were generally excluded from systemic drug development, they promise slower resistance development than many classical drugs that target single proteins. The success of daptomycin together with the emergence of more and more multi-resistant superbugs attracted renewed interest in this compound class. Studying daptomycin as a pioneering systemic membrane-active compound might help to pave the way for future membrane-targeting antibiotics. However, more than 30 years after its discovery, the exact mechanism of action of daptomycin is still debated. In particular, there is a prominent discrepancy between in vivo and in vitro studies. In this review, we discuss the current knowledge on the mechanism of daptomycin against Gram-positive bacteria and try to offer explanations for these conflicting observations.
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Citations by publishers
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2
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14
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1 publication, 1.56%
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Public Library of Science (PLoS)
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1 publication, 1.56%
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1 publication, 1.56%
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1 publication, 1.56%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Gray D. A., Wenzel M. More Than a Pore: A Current Perspective on the In Vivo Mode of Action of the Lipopeptide Antibiotic Daptomycin // Antibiotics. 2020. Vol. 9. No. 1. p. 17.
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Gray D. A., Wenzel M. More Than a Pore: A Current Perspective on the In Vivo Mode of Action of the Lipopeptide Antibiotic Daptomycin // Antibiotics. 2020. Vol. 9. No. 1. p. 17.
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TY - JOUR
DO - 10.3390/antibiotics9010017
UR - https://doi.org/10.3390%2Fantibiotics9010017
TI - More Than a Pore: A Current Perspective on the In Vivo Mode of Action of the Lipopeptide Antibiotic Daptomycin
T2 - Antibiotics
AU - Gray, Declan Alan
AU - Wenzel, Michaela
PY - 2020
DA - 2020/01/03 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 17
IS - 1
VL - 9
PMID - 31947747
SN - 2079-6382
ER -
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@article{2020_Gray,
author = {Declan Alan Gray and Michaela Wenzel},
title = {More Than a Pore: A Current Perspective on the In Vivo Mode of Action of the Lipopeptide Antibiotic Daptomycin},
journal = {Antibiotics},
year = {2020},
volume = {9},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jan},
url = {https://doi.org/10.3390%2Fantibiotics9010017},
number = {1},
pages = {17},
doi = {10.3390/antibiotics9010017}
}
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MLA
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Gray, Declan Alan, and Michaela Wenzel. “More Than a Pore: A Current Perspective on the In Vivo Mode of Action of the Lipopeptide Antibiotic Daptomycin.” Antibiotics, vol. 9, no. 1, Jan. 2020, p. 17. https://doi.org/10.3390%2Fantibiotics9010017.