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Antioxidants, volume 11, issue 3, pages 549

Sex-Dependent Protective Effect of Combined Application of Solubilized Ubiquinol and Selenium on Monocrotaline-Induced Pulmonary Hypertension in Wistar Rats

Kuropatkina Tatyana ¹

Pavlova Olga ^{1, 2}

Gulyaev Mikhail ¹

Pirogov Yury ²

Khutorova Anastasiya ³

Stvolinsky Sergey ³

Medvedeva Natalia ⁴

Medvedev Oleg ^{1, 5}

Hide authors affiliations Show authors affiliations: 5 affiliations

Faculty of Medicine, Lomonosov Moscow State University, Lomonosovsky Prospect 27-1, 119991 Moscow, Russia |

Faculty of Physics, Lomonosov Moscow State University, Leninskie Gory 1-2, 119991 Moscow, Russia |

Research Center of Neurology, Laboratory of Clinical and Experimental Neurochemistry, Volokolamskoye Shosse 80, 125367 Moscow, Russia |

⁴

Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, 119234 Moscow, Russia |

⁵

National Medical Research Center of Cardiology of the Ministry of Health of the Russian Federation, Laboratory of Experimental Pharmacology, 3rd Cherepkovskaya 15a, 121552 Moscow, Russia |

Publication type: Journal Article

Publication date: 2022-03-14

Multidisciplinary Digital Publishing Institute (MDPI)

Journal: Antioxidants

Quartile SCImago

Quartile WOS

Impact factor: 7

ISSN: 20763921

DOI: 10.3390/antiox11030549

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PubMed ID: 35326199

Biochemistry

Molecular Biology

Cell Biology

Clinical Biochemistry

Physiology

Abstract

Ubiquinol exhibits anti-inflammatory and antioxidant properties. Selenium is a part of a number of antioxidant enzymes. The monocrotaline inducible model of pulmonary hypertension used in this study includes pathological links that may act as an application for the use of ubiquinol with high bioavailability and selenium metabolic products. On day 1, male and female rats were subcutaneously injected with a water-alcohol solution of monocrotaline or only water-alcohol solution. On days 7 and 14, some animals were intravenously injected with either ubiquinol’s vehicle or solubilized ubiquinol, or orally with selenium powder daily, starting from day 7, or received both ubiquinol + selenium. Magnetic resonance imaging of the lungs was performed on day 20. Hemodynamic parameters and morphometry were measured on day 22. An increased right ventricle systolic pressure in relation to control was demonstrated in all groups of animals of both sexes, except the group of males receiving the combination of ubiquinol + selenium. The relative mass of the right ventricle did not differ from the control in all groups of males and females receiving either ubiquinol alone or the combination. Magnetic resonance imaging revealed impaired perfusion in almost all animals examined, but pulmonary fibrosis developed in only half of the animals in the ubiquinol group. Intravenous administration of ubiquinol has a protective effect on monocrotaline-induced pulmonary hypertension development resulting in reduced right ventricle hypertrophy, and lung mass. Ubiquinol + selenium administration resulted in a less severe increase in the right ventricle systolic pressure in male rats but not in females 3 weeks after the start of the experiment. This sex-dependent effect was not observed in the influence of ubiquinol alone.

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Citations by journals

	1
Applied Magnetic Resonance	Applied Magnetic Resonance, 1, 20% Applied Magnetic Resonance 1 publication, 20%
Pharmaceutics	Pharmaceutics, 1, 20% Pharmaceutics 1 publication, 20%
Biological Trace Element Research	Biological Trace Element Research, 1, 20% Biological Trace Element Research 1 publication, 20%
Magnetic Resonance in Medicine	Magnetic Resonance in Medicine, 1, 20% Magnetic Resonance in Medicine 1 publication, 20%
Pulmonologiya	Pulmonologiya, 1, 20% Pulmonologiya 1 publication, 20%
	1

Citations by publishers

	1 2
Springer Nature	Springer Nature, 2, 40% Springer Nature 2 publications, 40%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 1, 20% Multidisciplinary Digital Publishing Institute (MDPI) 1 publication, 20%
Wiley	Wiley, 1, 20% Wiley 1 publication, 20%
Federal Pulmonology Research Institute FMBA of Russia	Federal Pulmonology Research Institute FMBA of Russia, 1, 20% Federal Pulmonology Research Institute FMBA of Russia 1 publication, 20%
	1 2

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Kuropatkina T. et al. Sex-Dependent Protective Effect of Combined Application of Solubilized Ubiquinol and Selenium on Monocrotaline-Induced Pulmonary Hypertension in Wistar Rats // Antioxidants. 2022. Vol. 11. No. 3. p. 549.

GOST all authors (up to 50) Copy

Kuropatkina T., Pavlova O., Gulyaev M., Pirogov Y., Khutorova A., Stvolinsky S., Medvedeva N., Medvedev O. Sex-Dependent Protective Effect of Combined Application of Solubilized Ubiquinol and Selenium on Monocrotaline-Induced Pulmonary Hypertension in Wistar Rats // Antioxidants. 2022. Vol. 11. No. 3. p. 549.

RIS |

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RIS Copy

TY - JOUR

DO - 10.3390/antiox11030549

UR - https://doi.org/10.3390%2Fantiox11030549

TI - Sex-Dependent Protective Effect of Combined Application of Solubilized Ubiquinol and Selenium on Monocrotaline-Induced Pulmonary Hypertension in Wistar Rats

T2 - Antioxidants

AU - Kuropatkina, Tatyana

AU - Pirogov, Yury

AU - Khutorova, Anastasiya

AU - Stvolinsky, Sergey

AU - Medvedeva, Natalia

AU - Medvedev, Oleg

AU - Pavlova, Olga

AU - Gulyaev, Mikhail

PY - 2022

DA - 2022/03/14 00:00:00

PB - Multidisciplinary Digital Publishing Institute (MDPI)

SP - 549

IS - 3

VL - 11

PMID - 35326199

SN - 2076-3921

ER -

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@article{2022_Kuropatkina,

author = {Tatyana Kuropatkina and Yury Pirogov and Anastasiya Khutorova and Sergey Stvolinsky and Natalia Medvedeva and Oleg Medvedev and Olga Pavlova and Mikhail Gulyaev},

title = {Sex-Dependent Protective Effect of Combined Application of Solubilized Ubiquinol and Selenium on Monocrotaline-Induced Pulmonary Hypertension in Wistar Rats},

journal = {Antioxidants},

year = {2022},

volume = {11},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

month = {mar},

url = {https://doi.org/10.3390%2Fantiox11030549},

number = {3},

pages = {549},

doi = {10.3390/antiox11030549}

}

MLA

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MLA Copy

Kuropatkina, Tatyana, et al. “Sex-Dependent Protective Effect of Combined Application of Solubilized Ubiquinol and Selenium on Monocrotaline-Induced Pulmonary Hypertension in Wistar Rats.” Antioxidants, vol. 11, no. 3, Mar. 2022, p. 549. https://doi.org/10.3390%2Fantiox11030549.

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Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

Journal

Antioxidants

Quartile SCImago

Quartile WOS

Impact factor

ISSN

20763921 (Electronic)

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