Open Access
Antioxidants, volume 9, issue 10, pages 972
Antibacterial Activity of Synthetic Cationic Iron Porphyrins
1
Division of Neurobiology, Ivy Brain Tumor Center, Barrow Neurological Institute, Phoenix, AZ 85013, USA
|
2
Department of Radiation Oncology, Duke University School of Medicine, Durham, NC 27710, USA
|
Publication type: Journal Article
Publication date: 2020-10-10
PubMed ID:
33050461
Biochemistry
Molecular Biology
Cell Biology
Clinical Biochemistry
Physiology
Abstract
Widespread antibiotic resistance demands new strategies for fighting infections. Porphyrin-based compounds were long ago introduced as photosensitizers for photodynamic therapy, but light-independent antimicrobial activity of such compounds has not been systematically explored. The results of this study demonstrate that synthetic cationic amphiphilic iron N-alkylpyridylporphyrins exert strong bactericidal action at concentrations as low as 5 μM. Iron porphyrin, FeTnHex-2-PyP, which is well tolerated by laboratory animals, efficiently killed Gram-negative and Gram-positive microorganisms. Its bactericidal activity was oxygen-independent and was controlled by the lipophilicity and accumulation of the compound in bacterial cells. Such behavior is in contrast with the anionic gallium protoporphyrin IX, whose efficacy depends on cellular heme uptake systems. Under aerobic conditions, however, the activity of FeTnHex-2-PyP was limited by its destruction due to redox-cycling. Neither iron released from the Fe-porphyrin nor other decomposition products were the cause of the bactericidal activity. FeTnHex-2-PyP was as efficient against antibiotic-sensitive E. coli and S. aureus as against their antibiotic-resistant counterparts. Our data demonstrate that development of amphiphilic, positively charged metalloporphyrins might be a promising approach in the introduction of new weapons against antibiotic-resistant strains.
Citations by journals
|
1
|
|
|
International Journal of Molecular Sciences
|
International Journal of Molecular Sciences
1 publication, 10%
|
|
Nature Reviews Chemistry
|
Nature Reviews Chemistry
1 publication, 10%
|
|
Journal of Functional Biomaterials
|
Journal of Functional Biomaterials
1 publication, 10%
|
|
Photochemical and Photobiological Sciences
|
Photochemical and Photobiological Sciences
1 publication, 10%
|
|
ACS Infectious Diseases
|
ACS Infectious Diseases
1 publication, 10%
|
|
Inorganica Chimica Acta
|
Inorganica Chimica Acta
1 publication, 10%
|
|
Photodiagnosis and Photodynamic Therapy
|
Photodiagnosis and Photodynamic Therapy
1 publication, 10%
|
|
Journal of Cosmetic Dermatology
|
Journal of Cosmetic Dermatology
1 publication, 10%
|
|
Free Radical Research
|
Free Radical Research
1 publication, 10%
|
|
BIO Web of Conferences
|
BIO Web of Conferences
1 publication, 10%
|
|
1
|
Citations by publishers
|
1
2
|
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 20%
|
|
Springer Nature
|
Springer Nature
2 publications, 20%
|
|
Elsevier
|
Elsevier
2 publications, 20%
|
|
American Chemical Society (ACS)
|
American Chemical Society (ACS)
1 publication, 10%
|
|
Wiley
|
Wiley
1 publication, 10%
|
|
Taylor & Francis
|
Taylor & Francis
1 publication, 10%
|
|
EDP Sciences
|
EDP Sciences
1 publication, 10%
|
|
1
2
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2021,2022,2023,2024],"ids":[0,0,0,0],"codes":[0,0,0,0],"imageUrls":["","","",""],"datasets":[{"label":"Citations number","data":[2,1,6,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["20","10","60","10"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["International Journal of Molecular Sciences","Nature Reviews Chemistry","Journal of Functional Biomaterials","Photochemical and Photobiological Sciences","ACS Infectious Diseases","Inorganica Chimica Acta","Photodiagnosis and Photodynamic Therapy","Journal of Cosmetic Dermatology","Free Radical Research","BIO Web of Conferences"],"ids":[14627,6657,19043,2532,7781,1406,7488,17935,17295,28421],"codes":[0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/7GcDgL5Sa2zewDk4sRy4fs0GznbYZIsSV9wqMs28_medium.webp"],"datasets":[{"label":"","data":[1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[10,10,10,10,10,10,10,10,10,10],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Multidisciplinary Digital Publishing Institute (MDPI)","Springer Nature","Elsevier","American Chemical Society (ACS)","Wiley","Taylor & Francis","EDP Sciences"],"ids":[202,8,17,40,11,18,76],"codes":[0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/7GcDgL5Sa2zewDk4sRy4fs0GznbYZIsSV9wqMs28_medium.webp"],"datasets":[{"label":"","data":[2,2,2,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[20,20,20,10,10,10,10],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Tovmasyan A., Batinic-Haberle I., Benov L. Antibacterial Activity of Synthetic Cationic Iron Porphyrins // Antioxidants. 2020. Vol. 9. No. 10. p. 972.
GOST all authors (up to 50)
Copy
Tovmasyan A., Batinic-Haberle I., Benov L. Antibacterial Activity of Synthetic Cationic Iron Porphyrins // Antioxidants. 2020. Vol. 9. No. 10. p. 972.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/antiox9100972
UR - https://doi.org/10.3390%2Fantiox9100972
TI - Antibacterial Activity of Synthetic Cationic Iron Porphyrins
T2 - Antioxidants
AU - Batinic-Haberle, Ines
AU - Tovmasyan, Artak
AU - Benov, Ludmil
PY - 2020
DA - 2020/10/10 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 972
IS - 10
VL - 9
PMID - 33050461
SN - 2076-3921
ER -
Cite this
BibTex
Copy
@article{2020_Tovmasyan,
author = {Ines Batinic-Haberle and Artak Tovmasyan and Ludmil Benov},
title = {Antibacterial Activity of Synthetic Cationic Iron Porphyrins},
journal = {Antioxidants},
year = {2020},
volume = {9},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {oct},
url = {https://doi.org/10.3390%2Fantiox9100972},
number = {10},
pages = {972},
doi = {10.3390/antiox9100972}
}
Cite this
MLA
Copy
Tovmasyan, Artak, et al. “Antibacterial Activity of Synthetic Cationic Iron Porphyrins.” Antioxidants, vol. 9, no. 10, Oct. 2020, p. 972. https://doi.org/10.3390%2Fantiox9100972.