Open Access
Bioengineering, volume 9, issue 1, pages 24
Unraveling the Mechanism of Platelet Aggregation Suppression by Monoterpenoids
Nikitina Liliya E.
1, 2
,
Gilfanov Ilmir R
2
,
Kiselev Sergei V
2
,
Azizova Zulfiya R
2
,
Bocharov Pavel S
3, 4
,
Antina Elena V.
3
,
Klochkov Vladimir V
1
,
Timerova Ayzira F
1
,
Rakhmatullin Ilfat Z.
1
,
Ostolopovskaya Olga V
1, 2
,
Khelkhal Mohammed A
1
,
Boichuk Sergei
2
,
Frolova Larisa L.
6
,
Kutchin Alexander V
6
,
1
Publication type: Journal Article
Publication date: 2022-01-10
PubMed ID:
35049733
Bioengineering
Abstract
Platelet aggregation causes various diseases and therefore challenges the development of novel antiaggregatory drugs. In this study, we report the possible mechanism of platelet aggregation suppression by newly synthesized myrtenol-derived monoterpenoids carrying different heteroatoms (sulphur, oxygen, or nitrogen). Despite all tested compounds suppressed the platelet aggregation in vitro, the most significant effect was observed for the S-containing compounds. The molecular docking confirmed the putative interaction of all tested compounds with the platelet’s P2Y12 receptor suggesting that the anti-aggregation properties of monoterpenoids are implemented by blocking the P2Y12 function. The calculated binding force depended on heteroatom in monoterpenoids and significantly decreased with the exchanging of the sulphur atom with oxygen or nitrogen. On the other hand, in NMR studies on dodecyl phosphocholine (DPC) as a membrane model, only S-containing compound was found to be bound with DPC micelles surface. Meanwhile, no stable complexes between DPC micelles with either O- or N-containing compounds were observed. The binding of S-containing compound with cellular membrane reinforces the mechanical properties of the latter, thereby preventing its destabilization and subsequent clot formation on the phospholipid surface. Taken together, our data demonstrate that S-containing myrtenol-derived monoterpenoid suppresses the platelet aggregation in vitro via both membrane stabilization and blocking the P2Y12 receptor and, thus, appears as a promising agent for hemostasis control.
Citations by journals
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1
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Biomolecules
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Biomolecules
1 publication, 20%
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MolBank
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MolBank
1 publication, 20%
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Biomimetics
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Biomimetics
1 publication, 20%
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Phytomedicine
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Phytomedicine
1 publication, 20%
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Russian Chemical Reviews
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Russian Chemical Reviews
1 publication, 20%
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1
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Citations by publishers
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1
2
3
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|
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 60%
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Elsevier
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Elsevier
1 publication, 20%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 20%
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1
2
3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Nikitina L. E. et al. Unraveling the Mechanism of Platelet Aggregation Suppression by Monoterpenoids // Bioengineering. 2022. Vol. 9. No. 1. p. 24.
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Nikitina L. E., Pavelyev R. S., Gilfanov I. R., Kiselev S. V., Azizova Z. R., Ksenofontov A. A., Bocharov P. S., Antina E. V., Klochkov V. V., Timerova A. F., Rakhmatullin I. Z., Ostolopovskaya O. V., Khelkhal M. A., Boichuk S., Galembikova A., Andriutsa N. S., Frolova L. L., Kutchin A. V., Kayumov A. R. Unraveling the Mechanism of Platelet Aggregation Suppression by Monoterpenoids // Bioengineering. 2022. Vol. 9. No. 1. p. 24.
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TY - JOUR
DO - 10.3390/bioengineering9010024
UR - https://doi.org/10.3390%2Fbioengineering9010024
TI - Unraveling the Mechanism of Platelet Aggregation Suppression by Monoterpenoids
T2 - Bioengineering
AU - Kiselev, Sergei V
AU - Azizova, Zulfiya R
AU - Timerova, Ayzira F
AU - Rakhmatullin, Ilfat Z.
AU - Ostolopovskaya, Olga V
AU - Khelkhal, Mohammed A
AU - Frolova, Larisa L.
AU - Kutchin, Alexander V
AU - Bocharov, Pavel S
AU - Gilfanov, Ilmir R
AU - Antina, Elena V.
AU - Klochkov, Vladimir V
AU - Nikitina, Liliya E.
AU - Pavelyev, Roman S.
AU - Ksenofontov, Alexander A
AU - Boichuk, Sergei
AU - Galembikova, Aigul
AU - Andriutsa, Natalia S
AU - Kayumov, Airat R.
PY - 2022
DA - 2022/01/10 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 24
IS - 1
VL - 9
PMID - 35049733
SN - 2306-5354
ER -
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@article{2022_Nikitina,
author = {Sergei V Kiselev and Zulfiya R Azizova and Ayzira F Timerova and Ilfat Z. Rakhmatullin and Olga V Ostolopovskaya and Mohammed A Khelkhal and Larisa L. Frolova and Alexander V Kutchin and Pavel S Bocharov and Ilmir R Gilfanov and Elena V. Antina and Vladimir V Klochkov and Liliya E. Nikitina and Roman S. Pavelyev and Alexander A Ksenofontov and Sergei Boichuk and Aigul Galembikova and Natalia S Andriutsa and Airat R. Kayumov},
title = {Unraveling the Mechanism of Platelet Aggregation Suppression by Monoterpenoids},
journal = {Bioengineering},
year = {2022},
volume = {9},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jan},
url = {https://doi.org/10.3390%2Fbioengineering9010024},
number = {1},
pages = {24},
doi = {10.3390/bioengineering9010024}
}
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Nikitina, Liliya E., et al. “Unraveling the Mechanism of Platelet Aggregation Suppression by Monoterpenoids.” Bioengineering, vol. 9, no. 1, Jan. 2022, p. 24. https://doi.org/10.3390%2Fbioengineering9010024.