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Unraveling the Mechanism of Platelet Aggregation Suppression by Monoterpenoids

Nikitina L.E., Pavelyev R.S., Gilfanov I.R., Kiselev S.V., Azizova Z.R., Ksenofontov A.A., Bocharov P.S., Antina E.V., Klochkov V.V., Timerova A.F., Rakhmatullin I.Z., Ostolopovskaya O.V., Khelkhal M.A., Boichuk S.V., Galembikova A.R., Andriutsa N.S., Frolova L.L., Kutchin A.V., Kayumov A.R.
Тип документаJournal Article
Дата публикации2022-01-10
Название журналаBioengineering
ИздательMultidisciplinary Digital Publishing Institute (MDPI)
Квартиль по SCImagoQ2
Квартиль по Web of ScienceQ2
Импакт-фактор 20215.05
ISSN23065354
Bioengineering
Краткое описание

Platelet aggregation causes various diseases and therefore challenges the development of novel antiaggregatory drugs. In this study, we report the possible mechanism of platelet aggregation suppression by newly synthesized myrtenol-derived monoterpenoids carrying different heteroatoms (sulphur, oxygen, or nitrogen). Despite all tested compounds suppressed the platelet aggregation in vitro, the most significant effect was observed for the S-containing compounds. The molecular docking confirmed the putative interaction of all tested compounds with the platelet’s P2Y12 receptor suggesting that the anti-aggregation properties of monoterpenoids are implemented by blocking the P2Y12 function. The calculated binding force depended on heteroatom in monoterpenoids and significantly decreased with the exchanging of the sulphur atom with oxygen or nitrogen. On the other hand, in NMR studies on dodecyl phosphocholine (DPC) as a membrane model, only S-containing compound was found to be bound with DPC micelles surface. Meanwhile, no stable complexes between DPC micelles with either O- or N-containing compounds were observed. The binding of S-containing compound with cellular membrane reinforces the mechanical properties of the latter, thereby preventing its destabilization and subsequent clot formation on the phospholipid surface. Taken together, our data demonstrate that S-containing myrtenol-derived monoterpenoid suppresses the platelet aggregation in vitro via both membrane stabilization and blocking the P2Y12 receptor and, thus, appears as a promising agent for hemostasis control.

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ГОСТ |
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1. Nikitina L. E. и др. Unraveling the Mechanism of Platelet Aggregation Suppression by Monoterpenoids // Bioengineering. 2022. Т. 9. № 1. С. 24.
RIS |
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TY - JOUR

DO - 10.3390/bioengineering9010024

UR - http://dx.doi.org/10.3390/bioengineering9010024

TI - Unraveling the Mechanism of Platelet Aggregation Suppression by Monoterpenoids

T2 - Bioengineering

AU - Nikitina, Liliya E.

AU - Pavelyev, Roman S.

AU - Gilfanov, Ilmir R.

AU - Kiselev, Sergei V.

AU - Azizova, Zulfiya R.

AU - Ksenofontov, Alexander A.

AU - Bocharov, Pavel S.

AU - Antina, Elena V.

AU - Klochkov, Vladimir V.

AU - Timerova, Ayzira F.

AU - Rakhmatullin, Ilfat Z.

AU - Ostolopovskaya, Olga V.

AU - Khelkhal, Mohammed A.

AU - Boichuk, Sergei V.

AU - Galembikova, Aigul R.

AU - Andriutsa, Natalia S.

AU - Frolova, Larisa L.

AU - Kutchin, Alexander V.

AU - Kayumov, Airat R.

PY - 2022

DA - 2022/01/10

PB - MDPI AG

SP - 24

IS - 1

VL - 9

SN - 2306-5354

ER -

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@article{Nikitina_2022,

doi = {10.3390/bioengineering9010024},

url = {https://doi.org/10.3390%2Fbioengineering9010024},

year = 2022,

month = {jan},

publisher = {{MDPI} {AG}},

volume = {9},

number = {1},

pages = {24},

author = {Liliya E. Nikitina and Roman S. Pavelyev and Ilmir R. Gilfanov and Sergei V. Kiselev and Zulfiya R. Azizova and Alexander A. Ksenofontov and Pavel S. Bocharov and Elena V. Antina and Vladimir V. Klochkov and Ayzira F. Timerova and Ilfat Z. Rakhmatullin and Olga V. Ostolopovskaya and Mohammed A. Khelkhal and Sergei V. Boichuk and Aigul R. Galembikova and Natalia S. Andriutsa and Larisa L. Frolova and Alexander V. Kutchin and Airat R. Kayumov},

title = {Unraveling the Mechanism of Platelet Aggregation Suppression by Monoterpenoids},

journal = {Bioengineering}

}

MLA
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Nikitina, Liliya E., et al. “Unraveling the Mechanism of Platelet Aggregation Suppression by Monoterpenoids.” Bioengineering, vol. 9, no. 1, Jan. 2022, p. 24. Crossref, https://doi.org/10.3390/bioengineering9010024.