Open Access
Biomolecules, volume 11, issue 9, pages 1284
Impact of G-Quadruplexes on the Regulation of Genome Integrity, DNA Damage and Repair
Publication type: Journal Article
Publication date: 2021-08-27
PubMed ID:
34572497
Biochemistry
Molecular Biology
Abstract
DNA G-quadruplexes (G4s) are known to be an integral part of the complex regulatory systems in both normal and pathological cells. At the same time, the ability of G4s to impede DNA replication plays a critical role in genome integrity. This review summarizes the results of recent studies of G4-mediated genomic and epigenomic instability, together with associated DNA damage and repair processes. Although the underlying mechanisms remain to be elucidated, it is known that, among the proteins that recognize G4 structures, many are linked to DNA repair. We analyzed the possible role of G4s in promoting double-strand DNA breaks, one of the most deleterious DNA lesions, and their repair via error-prone mechanisms. The patterns of G4 damage, with a focus on the introduction of oxidative guanine lesions, as well as their removal from G4 structures by canonical repair pathways, were also discussed together with the effects of G4s on the repair machinery. According to recent findings, there must be a delicate balance between G4-induced genome instability and G4-promoted repair processes. A broad overview of the factors that modulate the stability of G4 structures in vitro and in vivo is also provided here.
Citations by journals
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International Journal of Molecular Sciences
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DNA
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Biochemistry (Moscow)
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1 publication, 3.57%
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Life
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1 publication, 3.57%
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1 publication, 3.57%
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1 publication, 3.57%
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1 publication, 3.57%
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Molecular Diversity
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1 publication, 3.57%
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Citations by publishers
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14
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
14 publications, 50%
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Elsevier
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Elsevier
4 publications, 14.29%
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Oxford University Press
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Oxford University Press
2 publications, 7.14%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
1 publication, 3.57%
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Mary Ann Liebert
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Mary Ann Liebert
1 publication, 3.57%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 3.57%
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Springer Nature
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Springer Nature
1 publication, 3.57%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Pavlova G. V. et al. Impact of G-Quadruplexes on the Regulation of Genome Integrity, DNA Damage and Repair // Biomolecules. 2021. Vol. 11. No. 9. p. 1284.
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Pavlova G. V., KUBAREVA E. A., Monakhova M. V., Zvereva M., Dolinnaya N. Impact of G-Quadruplexes on the Regulation of Genome Integrity, DNA Damage and Repair // Biomolecules. 2021. Vol. 11. No. 9. p. 1284.
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TY - JOUR
DO - 10.3390/biom11091284
UR - https://doi.org/10.3390%2Fbiom11091284
TI - Impact of G-Quadruplexes on the Regulation of Genome Integrity, DNA Damage and Repair
T2 - Biomolecules
AU - KUBAREVA, ELENA A.
AU - Pavlova, G V
AU - Monakhova, Mayya V
AU - Zvereva, Maria
AU - Dolinnaya, Nina
PY - 2021
DA - 2021/08/27 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1284
IS - 9
VL - 11
PMID - 34572497
SN - 2218-273X
ER -
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@article{2021_Pavlova,
author = {ELENA A. KUBAREVA and G V Pavlova and Mayya V Monakhova and Maria Zvereva and Nina Dolinnaya},
title = {Impact of G-Quadruplexes on the Regulation of Genome Integrity, DNA Damage and Repair},
journal = {Biomolecules},
year = {2021},
volume = {11},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {aug},
url = {https://doi.org/10.3390%2Fbiom11091284},
number = {9},
pages = {1284},
doi = {10.3390/biom11091284}
}
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MLA
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Pavlova, G. V., et al. “Impact of G-Quadruplexes on the Regulation of Genome Integrity, DNA Damage and Repair.” Biomolecules, vol. 11, no. 9, Aug. 2021, p. 1284. https://doi.org/10.3390%2Fbiom11091284.