Open Access
Biomolecules, volume 12, issue 1, pages 93
The Sphingolipid Asset Is Altered in the Nigrostriatal System of Mice Models of Parkinson’s Disease
Blokhin Victor
1
,
Shupik Maria
2
,
Gutner Ulyana
2
,
Pavlova Ekaterina
1
,
Maloshitskaya Olga
2, 3
,
Bogdanov Vsevolod
1
,
Sokolov Sergey
3
,
Alessenko Alice
2
,
Ugrumov Michael
1
Publication type: Journal Article
Publication date: 2022-01-06
PubMed ID:
35053241
Biochemistry
Molecular Biology
Abstract
Parkinson’s disease (PD) is a neurodegenerative disease incurable due to late diagnosis and treatment. Therefore, one of the priorities of neurology is to study the mechanisms of PD pathogenesis at the preclinical and early clinical stages. Given the important role of sphingolipids in the pathogenesis of neurodegenerative diseases, we aimed to analyze the gene expression of key sphingolipid metabolism enzymes (ASAH1, ASAH2, CERS1, CERS3, CERS5, GBA1, SMPD1, SMPD2, UGCG) and the content of 32 sphingolipids (subspecies of ceramides, sphingomyelins, monohexosylceramides and sphinganine, sphingosine, and sphingosine-1-phosphate) in the nigrostriatal system in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse models of the preclinical and clinical stages of PD. It has been shown that in PD models, the expression of five of the nine studied genes (CERS1, CERS5, ASAH1, ASAH2, and GBA1) increases but only in the substantia nigra (SN) containing dopaminergic cell bodies. Changes in the expression of enzyme genes were accompanied by an increase in the content of 7 of the 32 studied sphingolipids. Such findings suggest these genes as attractive candidates for diagnostic purposes for preclinical and clinical stages of PD.
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Frontiers in Genetics
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Frontiers in Genetics
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 50%
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Blokhin V. et al. The Sphingolipid Asset Is Altered in the Nigrostriatal System of Mice Models of Parkinson’s Disease // Biomolecules. 2022. Vol. 12. No. 1. p. 93.
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Blokhin V., Shupik M., Gutner U., Pavlova E., Lebedev A. T., Maloshitskaya O., Bogdanov V., Sokolov S., Alessenko A., Ugrumov M. The Sphingolipid Asset Is Altered in the Nigrostriatal System of Mice Models of Parkinson’s Disease // Biomolecules. 2022. Vol. 12. No. 1. p. 93.
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TY - JOUR
DO - 10.3390/biom12010093
UR - https://doi.org/10.3390%2Fbiom12010093
TI - The Sphingolipid Asset Is Altered in the Nigrostriatal System of Mice Models of Parkinson’s Disease
T2 - Biomolecules
AU - Shupik, Maria
AU - Gutner, Ulyana
AU - Pavlova, Ekaterina
AU - Maloshitskaya, Olga
AU - Bogdanov, Vsevolod
AU - Sokolov, Sergey
AU - Alessenko, Alice
AU - Ugrumov, Michael
AU - Blokhin, Victor
AU - Lebedev, Albert T.
PY - 2022
DA - 2022/01/06 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 93
IS - 1
VL - 12
PMID - 35053241
SN - 2218-273X
ER -
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@article{2022_Blokhin,
author = {Maria Shupik and Ulyana Gutner and Ekaterina Pavlova and Olga Maloshitskaya and Vsevolod Bogdanov and Sergey Sokolov and Alice Alessenko and Michael Ugrumov and Victor Blokhin and Albert T. Lebedev},
title = {The Sphingolipid Asset Is Altered in the Nigrostriatal System of Mice Models of Parkinson’s Disease},
journal = {Biomolecules},
year = {2022},
volume = {12},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jan},
url = {https://doi.org/10.3390%2Fbiom12010093},
number = {1},
pages = {93},
doi = {10.3390/biom12010093}
}
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Blokhin, Victor, et al. “The Sphingolipid Asset Is Altered in the Nigrostriatal System of Mice Models of Parkinson’s Disease.” Biomolecules, vol. 12, no. 1, Jan. 2022, p. 93. https://doi.org/10.3390%2Fbiom12010093.
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