Open Access
Biomedicines, volume 10, issue 3, pages 728
Detection of TERT Promoter Mutations as a Prognostic Biomarker in Gliomas: Methodology, Prospects, and Advances
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Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Takatsuki 569-8686, Japan
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6
Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC), 69372 Lyon, France
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Publication type: Journal Article
Publication date: 2022-03-21
PubMed ID:
35327529
General Biochemistry, Genetics and Molecular Biology
Medicine (miscellaneous)
Abstract
This article reviews the existing approaches to determining the TERT promoter mutational status in patients with various tumoral diseases of the central nervous system. The operational characteristics of the most common methods and their transferability in medical practice for the selection or monitoring of personalized treatments based on the TERT status and other related molecular biomarkers in patients with the most common tumors, such as glioblastoma, oligodendroglioma, and astrocytoma, are compared. The inclusion of new molecular markers in the course of CNS clinical management requires their rapid and reliable assessment. Availability of molecular evaluation of gliomas facilitates timely decisions regarding patient follow-up with the selection of the most appropriate treatment protocols. Significant progress in the inclusion of molecular biomarkers for their subsequent clinical application has been made since 2016 when the WHO CNS classification first used molecular markers to classify gliomas. In this review, we consider the methodological approaches used to determine mutations in the promoter region of the TERT gene in tumors of the central nervous system. In addition to classical molecular genetical methods, other methods for determining TERT mutations based on mass spectrometry, magnetic resonance imaging, next-generation sequencing, and nanopore sequencing are reviewed with an assessment of advantages and disadvantages. Beyond that, noninvasive diagnostic methods based on the determination of the mutational status of the TERT promoter are discussed.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Hasanau T. et al. Detection of TERT Promoter Mutations as a Prognostic Biomarker in Gliomas: Methodology, Prospects, and Advances // Biomedicines. 2022. Vol. 10. No. 3. p. 728.
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Hasanau T., Pisarev E., Kisil O. V., Nonoguchi N., Le Calvez-Kelm F., Zvereva M. Detection of TERT Promoter Mutations as a Prognostic Biomarker in Gliomas: Methodology, Prospects, and Advances // Biomedicines. 2022. Vol. 10. No. 3. p. 728.
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TY - JOUR
DO - 10.3390/biomedicines10030728
UR - https://doi.org/10.3390%2Fbiomedicines10030728
TI - Detection of TERT Promoter Mutations as a Prognostic Biomarker in Gliomas: Methodology, Prospects, and Advances
T2 - Biomedicines
AU - Hasanau, Tsimur
AU - Nonoguchi, Naosuke
AU - Pisarev, Eduard
AU - Kisil, O V
AU - Le Calvez-Kelm, Florence
AU - Zvereva, Maria
PY - 2022
DA - 2022/03/21 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 728
IS - 3
VL - 10
PMID - 35327529
SN - 2227-9059
ER -
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@article{2022_Hasanau,
author = {Tsimur Hasanau and Naosuke Nonoguchi and Eduard Pisarev and O V Kisil and Florence Le Calvez-Kelm and Maria Zvereva},
title = {Detection of TERT Promoter Mutations as a Prognostic Biomarker in Gliomas: Methodology, Prospects, and Advances},
journal = {Biomedicines},
year = {2022},
volume = {10},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {mar},
url = {https://doi.org/10.3390%2Fbiomedicines10030728},
number = {3},
pages = {728},
doi = {10.3390/biomedicines10030728}
}
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MLA
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Hasanau, Tsimur, et al. “Detection of TERT Promoter Mutations as a Prognostic Biomarker in Gliomas: Methodology, Prospects, and Advances.” Biomedicines, vol. 10, no. 3, Mar. 2022, p. 728. https://doi.org/10.3390%2Fbiomedicines10030728.