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Urokinase-Type Plasminogen Activator Enhances the Neuroprotective Activity of Brain-Derived Neurotrophic Factor in a Model of Intracerebral Hemorrhage

Dzhauari S., Litvinova S., Efimenko A., Aleksandrushkina N., Basalova N., Abakumov M., Danilova N., Malkov P., Balabanyan V., Bezuglova T., Balayants V., Mnikhovich M., Gulyaev M., Skryabina M., Popov V., Stambolsky D., Voronina T., Tkachuk V., Karagyaur M.
Тип документаJournal Article
Дата публикации2022-06-01
Название журналаBiomedicines
ИздательMultidisciplinary Digital Publishing Institute (MDPI)
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ2
Импакт-фактор 20214.76
ISSN22279059
General Biochemistry, Genetics and Molecular Biology
Medicine (miscellaneous)
Краткое описание
Brain-derived neurotrophic factor (BDNF) is a classic neuroprotective and pro-regenerative factor in peripheral and central nervous tissue. Its ability to stimulate the restoration of damaged nerve and brain tissue after ischemic stroke and intraventricular hemorrhage has been demonstrated. However, the current concept of regeneration allows us to assert that one factor, even if essential, cannot be the sole contributor to this complex biological process. We have previously shown that urokinase-type plasminogen activator (uPA) complements BDNF activity and stimulates restoration of nervous tissue. Using a model of intracerebral hemorrhage in rats, we investigated the neurotrophic and neuroprotective effect of BDNF combined with uPA. The local simultaneous administration of BDNF and uPA provided effective neuroprotection of brain tissue after intracerebral hemorrhage, promoted survival of experimental animals and their neurological recovery, and decreased lesion volume. The study of cellular mechanisms of the observed neurotrophic effect of BDNF and uPA combination revealed both known mechanisms (neuronal survival and neurite growth) and new ones (microglial activation) that had not been shown for BDNF and uPA. Our findings support the concept of using combinations of biological factors with diverse but complementary mechanisms of action as a promising regenerative approach.
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1. Dzhauari S. и др. Urokinase-Type Plasminogen Activator Enhances the Neuroprotective Activity of Brain-Derived Neurotrophic Factor in a Model of Intracerebral Hemorrhage // Biomedicines. 2022. Т. 10. № 6. С. 1346.
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TY - JOUR

DO - 10.3390/biomedicines10061346

UR - http://dx.doi.org/10.3390/biomedicines10061346

TI - Urokinase-Type Plasminogen Activator Enhances the Neuroprotective Activity of Brain-Derived Neurotrophic Factor in a Model of Intracerebral Hemorrhage

T2 - Biomedicines

AU - Dzhauari, Stalik

AU - Litvinova, Svetlana

AU - Efimenko, Anastasia

AU - Aleksandrushkina, Natalia

AU - Basalova, Nataliya

AU - Abakumov, Maxim

AU - Danilova, Natalia

AU - Malkov, Pavel

AU - Balabanyan, Vadim

AU - Bezuglova, Tatiana

AU - Balayants, Viktor

AU - Mnikhovich, Maxim

AU - Gulyaev, Mikhail

AU - Skryabina, Mariya

AU - Popov, Vladimir

AU - Stambolsky, Dmitry

AU - Voronina, Tatiana

AU - Tkachuk, Vsevolod

AU - Karagyaur, Maxim

PY - 2022

DA - 2022/06/08

PB - MDPI AG

SP - 1346

IS - 6

VL - 10

SN - 2227-9059

ER -

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@article{Dzhauari_2022,

doi = {10.3390/biomedicines10061346},

url = {https://doi.org/10.3390%2Fbiomedicines10061346},

year = 2022,

month = {jun},

publisher = {{MDPI} {AG}},

volume = {10},

number = {6},

pages = {1346},

author = {Stalik Dzhauari and Svetlana Litvinova and Anastasia Efimenko and Natalia Aleksandrushkina and Nataliya Basalova and Maxim Abakumov and Natalia Danilova and Pavel Malkov and Vadim Balabanyan and Tatiana Bezuglova and Viktor Balayants and Maxim Mnikhovich and Mikhail Gulyaev and Mariya Skryabina and Vladimir Popov and Dmitry Stambolsky and Tatiana Voronina and Vsevolod Tkachuk and Maxim Karagyaur},

title = {Urokinase-Type Plasminogen Activator Enhances the Neuroprotective Activity of Brain-Derived Neurotrophic Factor in a Model of Intracerebral Hemorrhage},

journal = {Biomedicines}

}

MLA
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Dzhauari, Stalik, et al. “Urokinase-Type Plasminogen Activator Enhances the Neuroprotective Activity of Brain-Derived Neurotrophic Factor in a Model of Intracerebral Hemorrhage.” Biomedicines, vol. 10, no. 6, June 2022, p. 1346. Crossref, https://doi.org/10.3390/biomedicines10061346.