Open Access
Biomedicines, volume 10, issue 6, pages 1346
Urokinase-Type Plasminogen Activator Enhances the Neuroprotective Activity of Brain-Derived Neurotrophic Factor in a Model of Intracerebral Hemorrhage
Dzhauari Stalik
1
,
Litvinova Svetlana
2
,
Efimenko Anastasia
1, 3
,
Alexandrushkina Natalia A
1, 3
,
Basalova Nataliya
1, 3
,
Abakumov Maxim
4, 5
,
Danilova Natalia
6
,
Malkov Pavel
6
,
Balabanyan Vadim
1, 3
,
Balayants Viktor
7
,
Mnikhovich Maxim
7
,
Gulyaev Mikhail
1
,
Skryabina Mariya
1
,
Popov Vladimir
1
,
Voronina Tatiana
2
,
Tkachuk Vsevolod
1, 3
,
Karagyaur Maxim N.
1, 3
Publication type: Journal Article
Publication date: 2022-06-08
PubMed ID:
35740368
General Biochemistry, Genetics and Molecular Biology
Medicine (miscellaneous)
Abstract
Brain-derived neurotrophic factor (BDNF) is a classic neuroprotective and pro-regenerative factor in peripheral and central nervous tissue. Its ability to stimulate the restoration of damaged nerve and brain tissue after ischemic stroke and intraventricular hemorrhage has been demonstrated. However, the current concept of regeneration allows us to assert that one factor, even if essential, cannot be the sole contributor to this complex biological process. We have previously shown that urokinase-type plasminogen activator (uPA) complements BDNF activity and stimulates restoration of nervous tissue. Using a model of intracerebral hemorrhage in rats, we investigated the neurotrophic and neuroprotective effect of BDNF combined with uPA. The local simultaneous administration of BDNF and uPA provided effective neuroprotection of brain tissue after intracerebral hemorrhage, promoted survival of experimental animals and their neurological recovery, and decreased lesion volume. The study of cellular mechanisms of the observed neurotrophic effect of BDNF and uPA combination revealed both known mechanisms (neuronal survival and neurite growth) and new ones (microglial activation) that had not been shown for BDNF and uPA. Our findings support the concept of using combinations of biological factors with diverse but complementary mechanisms of action as a promising regenerative approach.
Citations by journals
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1
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Pharmaceutics
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Pharmaceutics
1 publication, 50%
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Neurochemical Journal
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Neurochemical Journal
1 publication, 50%
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1
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Citations by publishers
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1
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 50%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 50%
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1
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Dzhauari S. et al. Urokinase-Type Plasminogen Activator Enhances the Neuroprotective Activity of Brain-Derived Neurotrophic Factor in a Model of Intracerebral Hemorrhage // Biomedicines. 2022. Vol. 10. No. 6. p. 1346.
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Dzhauari S., Litvinova S., Efimenko A., Alexandrushkina N. A., Basalova N., Abakumov M., Danilova N., Malkov P., Balabanyan V., Bezuglova T., Balayants V., Mnikhovich M., Gulyaev M., Skryabina M., Popov V., Stambolsky D., Voronina T., Tkachuk V., Karagyaur M. N. Urokinase-Type Plasminogen Activator Enhances the Neuroprotective Activity of Brain-Derived Neurotrophic Factor in a Model of Intracerebral Hemorrhage // Biomedicines. 2022. Vol. 10. No. 6. p. 1346.
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TY - JOUR
DO - 10.3390/biomedicines10061346
UR - https://doi.org/10.3390%2Fbiomedicines10061346
TI - Urokinase-Type Plasminogen Activator Enhances the Neuroprotective Activity of Brain-Derived Neurotrophic Factor in a Model of Intracerebral Hemorrhage
T2 - Biomedicines
AU - Dzhauari, Stalik
AU - Abakumov, Maxim
AU - Malkov, Pavel
AU - Balabanyan, Vadim
AU - Balayants, Viktor
AU - Mnikhovich, Maxim
AU - Voronina, Tatiana
AU - Tkachuk, Vsevolod
AU - Litvinova, Svetlana
AU - Danilova, Natalia
AU - Skryabina, Mariya
AU - Efimenko, Anastasia
AU - Alexandrushkina, Natalia A
AU - Basalova, Nataliya
AU - Bezuglova, Tatiana
AU - Gulyaev, Mikhail
AU - Popov, Vladimir
AU - Stambolsky, Dmitry
AU - Karagyaur, Maxim N.
PY - 2022
DA - 2022/06/08 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1346
IS - 6
VL - 10
PMID - 35740368
SN - 2227-9059
ER -
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@article{2022_Dzhauari,
author = {Stalik Dzhauari and Maxim Abakumov and Pavel Malkov and Vadim Balabanyan and Viktor Balayants and Maxim Mnikhovich and Tatiana Voronina and Vsevolod Tkachuk and Svetlana Litvinova and Natalia Danilova and Mariya Skryabina and Anastasia Efimenko and Natalia A Alexandrushkina and Nataliya Basalova and Tatiana Bezuglova and Mikhail Gulyaev and Vladimir Popov and Dmitry Stambolsky and Maxim N. Karagyaur},
title = {Urokinase-Type Plasminogen Activator Enhances the Neuroprotective Activity of Brain-Derived Neurotrophic Factor in a Model of Intracerebral Hemorrhage},
journal = {Biomedicines},
year = {2022},
volume = {10},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jun},
url = {https://doi.org/10.3390%2Fbiomedicines10061346},
number = {6},
pages = {1346},
doi = {10.3390/biomedicines10061346}
}
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Dzhauari, Stalik, et al. “Urokinase-Type Plasminogen Activator Enhances the Neuroprotective Activity of Brain-Derived Neurotrophic Factor in a Model of Intracerebral Hemorrhage.” Biomedicines, vol. 10, no. 6, Jun. 2022, p. 1346. https://doi.org/10.3390%2Fbiomedicines10061346.