Open Access
Biomedicines, volume 11, issue 2, pages 396
gp130 Activates Mitochondrial Dynamics for Hepatocyte Survival in a Model of Steatohepatitis
Dakhnevich Anastasia
1
,
Shunkin Egor
1
,
Khaziakhmatova Olga
1
,
Shupletsova Valeria
1
,
Vulf Maria
1
,
Komar Aleksandra
1
,
Kirienkova Elena
1
,
Publication type: Journal Article
Publication date: 2023-01-29
General Biochemistry, Genetics and Molecular Biology
Medicine (miscellaneous)
Abstract
Obesity is the main cause of metabolic complications. Fatty liver infiltration is a companion of obesity. NAFLD is associated with impaired energy metabolism with an excess of nutrients. Mitochondrial dynamics are important for the regulation of energy balance, which regulates mitochondrial function, apoptosis, and mitophagy. The aim of this study was to investigate the effect of gp130 on the components of mitochondrial dynamics in a cellular model of steatohepatitis. Addition of IL-6/gp130 contributed to an increase in the percentage of live cells and a decrease in the percentage of dead and apoptotic cells. Addition of IL-6/gp130 increased the expression of NF-kB1 gene and mitochondrial dynamics markers (MFN2 and TFAM) in HepG2 with tBHP/Oleic. Addition of IL-6 or gp130 reduced the expression of cytoprotector genes (HSF1 and HSP70) in HepG2 cell cultures with tBHP/Oleic. Increased mitochondrial dynamics gene activity protected against HepG2 cell death in the steatohepatitis model. Trans-signaling resulted in increased TFAM and MAPLC3B, and decreased DNM1L gene expression in HepG2 with tBHP/Oleic.
Citations by journals
|
1
|
|
|
Medicina
|
Medicina
1 publication, 100%
|
|
1
|
Citations by publishers
|
1
|
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 100%
|
|
1
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2023],"ids":[0],"codes":[0],"imageUrls":[""],"datasets":[{"label":"Citations number","data":[1],"backgroundColor":["#3B82F6"],"percentage":["100"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Medicina"],"ids":[16451],"codes":[0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp"],"datasets":[{"label":"","data":[1],"backgroundColor":["#3B82F6"],"percentage":[100],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Multidisciplinary Digital Publishing Institute (MDPI)"],"ids":[202],"codes":[0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp"],"datasets":[{"label":"","data":[1],"backgroundColor":["#3B82F6"],"percentage":[100],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Skuratovskaia D. et al. gp130 Activates Mitochondrial Dynamics for Hepatocyte Survival in a Model of Steatohepatitis // Biomedicines. 2023. Vol. 11. No. 2. p. 396.
GOST all authors (up to 50)
Copy
Skuratovskaia D., Dakhnevich A., Shunkin E., Khaziakhmatova O., Shupletsova V., Vulf M., Komar A., Kirienkova E., Litvinova L. S. gp130 Activates Mitochondrial Dynamics for Hepatocyte Survival in a Model of Steatohepatitis // Biomedicines. 2023. Vol. 11. No. 2. p. 396.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/biomedicines11020396
UR - https://doi.org/10.3390%2Fbiomedicines11020396
TI - gp130 Activates Mitochondrial Dynamics for Hepatocyte Survival in a Model of Steatohepatitis
T2 - Biomedicines
AU - Skuratovskaia, Daria
AU - Dakhnevich, Anastasia
AU - Shunkin, Egor
AU - Khaziakhmatova, Olga
AU - Shupletsova, Valeria
AU - Vulf, Maria
AU - Komar, Aleksandra
AU - Kirienkova, Elena
AU - Litvinova, L. S.
PY - 2023
DA - 2023/01/29 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 396
IS - 2
VL - 11
SN - 2227-9059
ER -
Cite this
BibTex
Copy
@article{2023_Skuratovskaia,
author = {Daria Skuratovskaia and Anastasia Dakhnevich and Egor Shunkin and Olga Khaziakhmatova and Valeria Shupletsova and Maria Vulf and Aleksandra Komar and Elena Kirienkova and L. S. Litvinova},
title = {gp130 Activates Mitochondrial Dynamics for Hepatocyte Survival in a Model of Steatohepatitis},
journal = {Biomedicines},
year = {2023},
volume = {11},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jan},
url = {https://doi.org/10.3390%2Fbiomedicines11020396},
number = {2},
pages = {396},
doi = {10.3390/biomedicines11020396}
}
Cite this
MLA
Copy
Skuratovskaia, Daria, et al. “gp130 Activates Mitochondrial Dynamics for Hepatocyte Survival in a Model of Steatohepatitis.” Biomedicines, vol. 11, no. 2, Jan. 2023, p. 396. https://doi.org/10.3390%2Fbiomedicines11020396.