Open Access
The Role of Curcumin in Cancer Treatment
Vasiliki Zoi
1, 2
,
Vasiliki Galani
2
,
Georgios D. Lianos
3
,
Spyridon Voulgaris
1, 4
,
Athanassios P. Kyritsis
1
,
George A. Alexiou
1, 4
Publication type: Journal Article
Publication date: 2021-08-26
PubMed ID:
34572272
General Biochemistry, Genetics and Molecular Biology
Medicine (miscellaneous)
Abstract
Curcumin is a polyphenol extracted from the rhizomes of the turmeric plant, Curcuma longa which has anti-inflammatory, and anticancer properties. Chronic inflammation is associated with the development of cancer. Curcumin acts on the regulation of various immune modulators, including cytokines, cyclooxygenase-2 (COX-2), and reactive oxygen species (ROS), which partly explains its anticancer effects. It also takes part in the downregulation of growth factors, protein kinases, oncogenic molecules and various signaling pathways, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), c-Jun N-terminal kinase (JNK) and signal transducer and activator of transcription 3 (STAT3) signaling. Clinical trials of curcumin have been completed or are ongoing for various types of cancer. This review presents the molecular mechanisms of curcumin in different types of cancer and the evidence from the most recent clinical trials.
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Metrics
227
Total citations:
227
Citations from 2024:
180
(79.3%)
Cite this
GOST |
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BibTex |
MLA
Cite this
GOST
Copy
Zoi V. et al. The Role of Curcumin in Cancer Treatment // Biomedicines. 2021. Vol. 9. No. 9. p. 1086.
GOST all authors (up to 50)
Copy
Zoi V., Galani V., Lianos G. D., Voulgaris S., Kyritsis A. P., Alexiou G. A. The Role of Curcumin in Cancer Treatment // Biomedicines. 2021. Vol. 9. No. 9. p. 1086.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/biomedicines9091086
UR - https://doi.org/10.3390/biomedicines9091086
TI - The Role of Curcumin in Cancer Treatment
T2 - Biomedicines
AU - Zoi, Vasiliki
AU - Galani, Vasiliki
AU - Lianos, Georgios D.
AU - Voulgaris, Spyridon
AU - Kyritsis, Athanassios P.
AU - Alexiou, George A.
PY - 2021
DA - 2021/08/26
PB - MDPI
SP - 1086
IS - 9
VL - 9
PMID - 34572272
SN - 2227-9059
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Zoi,
author = {Vasiliki Zoi and Vasiliki Galani and Georgios D. Lianos and Spyridon Voulgaris and Athanassios P. Kyritsis and George A. Alexiou},
title = {The Role of Curcumin in Cancer Treatment},
journal = {Biomedicines},
year = {2021},
volume = {9},
publisher = {MDPI},
month = {aug},
url = {https://doi.org/10.3390/biomedicines9091086},
number = {9},
pages = {1086},
doi = {10.3390/biomedicines9091086}
}
Cite this
MLA
Copy
Zoi, Vasiliki, et al. “The Role of Curcumin in Cancer Treatment.” Biomedicines, vol. 9, no. 9, Aug. 2021, p. 1086. https://doi.org/10.3390/biomedicines9091086.