Open Access
Single-Chain Fragment Variable: Recent Progress in Cancer Diagnosis and Therapy
Paola Muñoz López
1, 2
,
Rosa María Ribas-Aparicio
2
,
Elayne Irene Becerra Báez
1, 3
,
Karla Fraga Pérez
1
,
Luis Fernando Flores Martínez
1
,
Armando Alfredo Mateos Chávez
1
,
Rosendo Luria-Pérez
1
Publication type: Journal Article
Publication date: 2022-08-30
PubMed ID:
36077739
Cancer Research
Oncology
Abstract
Cancer remains a public health problem worldwide. Although conventional therapies have led to some excellent outcomes, some patients fail to respond to treatment, they have few therapeutic alternatives and a poor survival prognosis. Several strategies have been proposed to overcome this issue. The most recent approach is immunotherapy, particularly the use of recombinant antibodies and their derivatives, such as the single-chain fragment variable (scFv) containing the complete antigen-binding domains of a whole antibody that successfully targets tumor cells. This review describes the recent progress made with scFvs as a cancer diagnostic and therapeutic tool, with an emphasis on preclinical approaches and their potential use in clinical trials.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
|
|
|
International Immunopharmacology
3 publications, 4.62%
|
|
|
Molecular Pharmaceutics
3 publications, 4.62%
|
|
|
Frontiers in Immunology
3 publications, 4.62%
|
|
|
Nature Communications
2 publications, 3.08%
|
|
|
International Journal of Biological Macromolecules
2 publications, 3.08%
|
|
|
International Journal of Pharmaceutics
2 publications, 3.08%
|
|
|
International Journal of Molecular Sciences
2 publications, 3.08%
|
|
|
Cells
1 publication, 1.54%
|
|
|
Colloids and Surfaces A: Physicochemical and Engineering Aspects
1 publication, 1.54%
|
|
|
Journal of Controlled Release
1 publication, 1.54%
|
|
|
Applied Biochemistry and Biotechnology
1 publication, 1.54%
|
|
|
Journal of Cancer Research and Clinical Oncology
1 publication, 1.54%
|
|
|
Process Biochemistry
1 publication, 1.54%
|
|
|
Applied Physics Reviews
1 publication, 1.54%
|
|
|
Cancers
1 publication, 1.54%
|
|
|
ImmunoHorizons
1 publication, 1.54%
|
|
|
Journal of Drug Delivery Science and Technology
1 publication, 1.54%
|
|
|
Life
1 publication, 1.54%
|
|
|
Cell Death Discovery
1 publication, 1.54%
|
|
|
Antibody Therapeutics
1 publication, 1.54%
|
|
|
Molecules
1 publication, 1.54%
|
|
|
Journal of Biological Engineering
1 publication, 1.54%
|
|
|
Journal of Pharmaceutical Analysis
1 publication, 1.54%
|
|
|
Biochemical Pharmacology
1 publication, 1.54%
|
|
|
Current Protein and Peptide Science
1 publication, 1.54%
|
|
|
Molecular Therapy
1 publication, 1.54%
|
|
|
Scientific Reports
1 publication, 1.54%
|
|
|
Pharmaceutics
1 publication, 1.54%
|
|
|
Journal of Immunological Methods
1 publication, 1.54%
|
|
|
1
2
3
|
Publishers
|
5
10
15
20
25
|
|
|
Elsevier
21 publications, 32.31%
|
|
|
Springer Nature
14 publications, 21.54%
|
|
|
MDPI
8 publications, 12.31%
|
|
|
American Chemical Society (ACS)
6 publications, 9.23%
|
|
|
Frontiers Media S.A.
4 publications, 6.15%
|
|
|
Cold Spring Harbor Laboratory
2 publications, 3.08%
|
|
|
AIP Publishing
1 publication, 1.54%
|
|
|
The American Association of Immunologists
1 publication, 1.54%
|
|
|
Oxford University Press
1 publication, 1.54%
|
|
|
Research Square Platform LLC
1 publication, 1.54%
|
|
|
Bentham Science Publishers Ltd.
1 publication, 1.54%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 1.54%
|
|
|
Taylor & Francis
1 publication, 1.54%
|
|
|
Public Library of Science (PLoS)
1 publication, 1.54%
|
|
|
Pleiades Publishing
1 publication, 1.54%
|
|
|
5
10
15
20
25
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
66
Total citations:
66
Citations from 2024:
50
(76%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Muñoz López P. et al. Single-Chain Fragment Variable: Recent Progress in Cancer Diagnosis and Therapy // Cancers. 2022. Vol. 14. No. 17. p. 4206.
GOST all authors (up to 50)
Copy
Muñoz López P., Ribas-Aparicio R. M., Becerra Báez E. I., Fraga Pérez K., Flores Martínez L. F., Mateos Chávez A. A., Luria-Pérez R. Single-Chain Fragment Variable: Recent Progress in Cancer Diagnosis and Therapy // Cancers. 2022. Vol. 14. No. 17. p. 4206.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/cancers14174206
UR - https://doi.org/10.3390/cancers14174206
TI - Single-Chain Fragment Variable: Recent Progress in Cancer Diagnosis and Therapy
T2 - Cancers
AU - Muñoz López, Paola
AU - Ribas-Aparicio, Rosa María
AU - Becerra Báez, Elayne Irene
AU - Fraga Pérez, Karla
AU - Flores Martínez, Luis Fernando
AU - Mateos Chávez, Armando Alfredo
AU - Luria-Pérez, Rosendo
PY - 2022
DA - 2022/08/30
PB - MDPI
SP - 4206
IS - 17
VL - 14
PMID - 36077739
SN - 2072-6694
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Muñoz López,
author = {Paola Muñoz López and Rosa María Ribas-Aparicio and Elayne Irene Becerra Báez and Karla Fraga Pérez and Luis Fernando Flores Martínez and Armando Alfredo Mateos Chávez and Rosendo Luria-Pérez},
title = {Single-Chain Fragment Variable: Recent Progress in Cancer Diagnosis and Therapy},
journal = {Cancers},
year = {2022},
volume = {14},
publisher = {MDPI},
month = {aug},
url = {https://doi.org/10.3390/cancers14174206},
number = {17},
pages = {4206},
doi = {10.3390/cancers14174206}
}
Cite this
MLA
Copy
Muñoz López, Paola, et al. “Single-Chain Fragment Variable: Recent Progress in Cancer Diagnosis and Therapy.” Cancers, vol. 14, no. 17, Aug. 2022, p. 4206. https://doi.org/10.3390/cancers14174206.