Open Access
Open access
MDPI
Cancers
,  volume 15 ,  issue 3 ,  pages 756

Pentacyclic Triterpenoids-Based Ionic Compounds: Synthesis, Study of Structure–Antitumor Activity Relationship, Effects on Mitochondria and Activation of Signaling Pathways of Proliferation, Genome Reparation and Early Apoptosis

Publication type: Journal Article
Publication date: 2023-01-26
MDPI
scimago Q1
wos Q2
SJR: 1.462
CiteScore: 8.8
Impact factor: 4.4
ISSN: 20726694
Cancer Research
Oncology
Abstract

The present research paper details the synthesis of novel ionic compounds based on triterpene acids (betulinic, oleanolic and ursolic), with these acids acting both as anions and connected through a spacer with various nitrogen-containing compounds (pyridine, piperidine, morpholine, pyrrolidine, triethylamine and dimethylethanolamine) and acting as a cation. Based on the latter, a large number of ionic compounds with various counterions (BF4-, SbF6-, PF6-, CH3COO-, C6H5SO3-, m-C6H4(OH)COO- and CH3CH(OH)COO-) have been synthesized. We studied the cytotoxicity of the synthesized compounds on the example of various tumor (Jurkat, K562, U937, HL60, A2780) and conditionally normal (HEK293) cell lines. IC50 was determined, and the influence of the structure and nature of the anion and cation on the antitumor activity was specified. Intracellular signaling, apoptosis induction and effects of the most active ionic compounds on the cell cycle and mitochondria have been discussed by applying modern methods of multiparametric enzyme immunoassay and flow cytometry.

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GOST Copy
Dzhemileva L. U. et al. Pentacyclic Triterpenoids-Based Ionic Compounds: Synthesis, Study of Structure–Antitumor Activity Relationship, Effects on Mitochondria and Activation of Signaling Pathways of Proliferation, Genome Reparation and Early Apoptosis // Cancers. 2023. Vol. 15. No. 3. p. 756.
GOST all authors (up to 50) Copy
Dzhemileva L. U., Tuktarova R. A., Dzhemilev U. M., D'yakonov V. A. Pentacyclic Triterpenoids-Based Ionic Compounds: Synthesis, Study of Structure–Antitumor Activity Relationship, Effects on Mitochondria and Activation of Signaling Pathways of Proliferation, Genome Reparation and Early Apoptosis // Cancers. 2023. Vol. 15. No. 3. p. 756.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.3390/cancers15030756
UR - https://doi.org/10.3390/cancers15030756
TI - Pentacyclic Triterpenoids-Based Ionic Compounds: Synthesis, Study of Structure–Antitumor Activity Relationship, Effects on Mitochondria and Activation of Signaling Pathways of Proliferation, Genome Reparation and Early Apoptosis
T2 - Cancers
AU - Dzhemileva, Lilya U.
AU - Tuktarova, Regina A.
AU - Dzhemilev, Usein M.
AU - D'yakonov, Vladimir A
PY - 2023
DA - 2023/01/26
PB - MDPI
SP - 756
IS - 3
VL - 15
PMID - 36765714
SN - 2072-6694
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Dzhemileva,
author = {Lilya U. Dzhemileva and Regina A. Tuktarova and Usein M. Dzhemilev and Vladimir A D'yakonov},
title = {Pentacyclic Triterpenoids-Based Ionic Compounds: Synthesis, Study of Structure–Antitumor Activity Relationship, Effects on Mitochondria and Activation of Signaling Pathways of Proliferation, Genome Reparation and Early Apoptosis},
journal = {Cancers},
year = {2023},
volume = {15},
publisher = {MDPI},
month = {jan},
url = {https://doi.org/10.3390/cancers15030756},
number = {3},
pages = {756},
doi = {10.3390/cancers15030756}
}
MLA
Cite this
MLA Copy
Dzhemileva, Lilya U., et al. “Pentacyclic Triterpenoids-Based Ionic Compounds: Synthesis, Study of Structure–Antitumor Activity Relationship, Effects on Mitochondria and Activation of Signaling Pathways of Proliferation, Genome Reparation and Early Apoptosis.” Cancers, vol. 15, no. 3, Jan. 2023, p. 756. https://doi.org/10.3390/cancers15030756.