Open Access
Catalysts, volume 10, issue 10, pages 1190
Biological Activities of NHC–Pd(II) Complexes Based on Benzimidazolylidene N-heterocyclic Carbene (NHC) Ligands Bearing Aryl Substituents
Ibrahim Al Nasr
1, 2
,
Nedra Touj
3
,
Waleed Koko
2
,
Tariq Khan
4
,
İlker Özdemir
5, 6
,
Sedat Yaşar
5, 6
,
Naceur Hamdi
3, 7
1
3
Research Laboratory of Environmental Sciences and Technologies (LR16ES09), Higher Institute of Environmental Sciences and Technology, University of Carthage, Hammam-Lif 2050, Tunisia
|
Publication type: Journal Article
Publication date: 2020-10-15
Catalysis
Physical and Theoretical Chemistry
Abstract
N-heterocyclic carbene (NHC) precursors (2a–i), their pyridine-enhanced precatalyst preparation stabilization and initiation (PEPPSI)-themed palladium N-heterocyclic carbene complexes (3a–i) and palladium N-heterocyclic triphenylphosphines complexes (4a–i) were synthesized and characterized by elemental analysis and 1H NMR, 13C NMR, IR, and LC–MS spectroscopic techniques. The (NHC)Pd(II) complexes 3–4 were tested against MCF7 and MDA-MB-231 cancer cells, Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA), Candida albicans microorganisms, Leishmania major promastigotes and amastigotes, Toxoplasma gondii parasites, and Vero cells in vitro. The biological assays indicated that all compounds are highly active against cancer cells, with an IC50 < 1.5 µg mL−1. Eight compounds proved antibacterial and antileishmanial activities, while only three compounds had strong antifungal activities against C. albicans. In our conclusion, compounds 3 (b, f, g, and h) and 4b are the most suitable drug candidates for anticancer, antimicrobial, and antiparasitical.
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Citations by publishers
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Al Nasr I. et al. Biological Activities of NHC–Pd(II) Complexes Based on Benzimidazolylidene N-heterocyclic Carbene (NHC) Ligands Bearing Aryl Substituents // Catalysts. 2020. Vol. 10. No. 10. p. 1190.
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Al Nasr I., Touj N., Koko W., Khan T., Özdemir İ., Yaşar S., Hamdi N. Biological Activities of NHC–Pd(II) Complexes Based on Benzimidazolylidene N-heterocyclic Carbene (NHC) Ligands Bearing Aryl Substituents // Catalysts. 2020. Vol. 10. No. 10. p. 1190.
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TY - JOUR
DO - 10.3390/catal10101190
UR - https://doi.org/10.3390/catal10101190
TI - Biological Activities of NHC–Pd(II) Complexes Based on Benzimidazolylidene N-heterocyclic Carbene (NHC) Ligands Bearing Aryl Substituents
T2 - Catalysts
AU - Al Nasr, Ibrahim
AU - Touj, Nedra
AU - Koko, Waleed
AU - Khan, Tariq
AU - Yaşar, Sedat
AU - Özdemir, İlker
AU - Hamdi, Naceur
PY - 2020
DA - 2020/10/15 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1190
IS - 10
VL - 10
SN - 2073-4344
SN - 2073-4344
ER -
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@article{2020_Al Nasr,
author = {Ibrahim Al Nasr and Nedra Touj and Waleed Koko and Tariq Khan and Sedat Yaşar and İlker Özdemir and Naceur Hamdi},
title = {Biological Activities of NHC–Pd(II) Complexes Based on Benzimidazolylidene N-heterocyclic Carbene (NHC) Ligands Bearing Aryl Substituents},
journal = {Catalysts},
year = {2020},
volume = {10},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {oct},
url = {https://doi.org/10.3390/catal10101190},
number = {10},
pages = {1190},
doi = {10.3390/catal10101190}
}
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MLA
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Al Nasr, Ibrahim, et al. “Biological Activities of NHC–Pd(II) Complexes Based on Benzimidazolylidene N-heterocyclic Carbene (NHC) Ligands Bearing Aryl Substituents.” Catalysts, vol. 10, no. 10, Oct. 2020, p. 1190. https://doi.org/10.3390/catal10101190.