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Catalysts

, volume 10 , issue 10 , pages 1190

Biological Activities of NHC–Pd(II) Complexes Based on Benzimidazolylidene N-heterocyclic Carbene (NHC) Ligands Bearing Aryl Substituents

Ibrahim Al Nasr ^{1, 2}

Nedra Touj ³

Waleed Koko ²

Tariq Khan ⁴

İlker Özdemir ^{5, 6}

Sedat Yaşar ^{5, 6}

Naceur Hamdi ^{3, 7}

Hide authors affiliations Show authors affiliations: 7 affiliations

Department of Biology, College of Science and Arts, Qassim University, Unaizah 51911, Saudi Arabia |

Department of Science Laboratories, College of Science and Arts, Qassim University, Ar Rass 52719, Saudi Arabia |

Research Laboratory of Environmental Sciences and Technologies (LR16ES09), Higher Institute of Environmental Sciences and Technology, University of Carthage, Hammam-Lif 2050, Tunisia |

⁴

Department of Clinical Nutrition, College of Applied Health Sciences, Qassim University, Ar Rass 52719, Saudi Arabia |

⁵

Department of Chemistry, Faculty of Science and Art, İnönü University, Malatya 44280, Turkey |

⁶

Catalysis Research and Application Center, İnönü University, Malatya 44280, Turkey |

⁷

Department of Chemistry, College of Science and Arts, Qassim University, Ar Rass 52719, Saudi Arabia |

Publication type: Journal Article

Publication date: 2020-10-15

MDPI

Catalysts

scimago Q2

wos Q2

SJR: 0.746

CiteScore: 7.6

Impact factor: 4.0

ISSN: 20734344

DOI: 10.3390/catal10101190

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Catalysis

Physical and Theoretical Chemistry

Abstract

N-heterocyclic carbene (NHC) precursors (2a–i), their pyridine-enhanced precatalyst preparation stabilization and initiation (PEPPSI)-themed palladium N-heterocyclic carbene complexes (3a–i) and palladium N-heterocyclic triphenylphosphines complexes (4a–i) were synthesized and characterized by elemental analysis and 1H NMR, 13C NMR, IR, and LC–MS spectroscopic techniques. The (NHC)Pd(II) complexes 3–4 were tested against MCF7 and MDA-MB-231 cancer cells, Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA), Candida albicans microorganisms, Leishmania major promastigotes and amastigotes, Toxoplasma gondii parasites, and Vero cells in vitro. The biological assays indicated that all compounds are highly active against cancer cells, with an IC50 < 1.5 µg mL−1. Eight compounds proved antibacterial and antileishmanial activities, while only three compounds had strong antifungal activities against C. albicans. In our conclusion, compounds 3 (b, f, g, and h) and 4b are the most suitable drug candidates for anticancer, antimicrobial, and antiparasitical.

Found

1 citation

Islamov Daut

PhD

168 publications, 1 552 citations

h-index: 20

Kazan Scientific Center of the Russian Academy of Sciences

Research interests

X-ray diffraction analysis

1 citation

Tikhonov Sergey

🥼 🤝

PhD in Chemistry

10 publications, 53 citations

h-index: 5

MIREA — Russian Technological University

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Al Nasr I. et al. Biological Activities of NHC–Pd(II) Complexes Based on Benzimidazolylidene N-heterocyclic Carbene (NHC) Ligands Bearing Aryl Substituents // Catalysts. 2020. Vol. 10. No. 10. p. 1190.

GOST all authors (up to 50) Copy

Al Nasr I., Touj N., Koko W., Khan T., Özdemir İ., Yaşar S., Hamdi N. Biological Activities of NHC–Pd(II) Complexes Based on Benzimidazolylidene N-heterocyclic Carbene (NHC) Ligands Bearing Aryl Substituents // Catalysts. 2020. Vol. 10. No. 10. p. 1190.

RIS |

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RIS Copy

TY - JOUR

DO - 10.3390/catal10101190

UR - https://doi.org/10.3390/catal10101190

TI - Biological Activities of NHC–Pd(II) Complexes Based on Benzimidazolylidene N-heterocyclic Carbene (NHC) Ligands Bearing Aryl Substituents

T2 - Catalysts

AU - Al Nasr, Ibrahim

AU - Touj, Nedra

AU - Koko, Waleed

AU - Khan, Tariq

AU - Özdemir, İlker

AU - Yaşar, Sedat

AU - Hamdi, Naceur

PY - 2020

DA - 2020/10/15

PB - MDPI

SP - 1190

IS - 10

VL - 10

SN - 2073-4344

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2020_Al Nasr,

author = {Ibrahim Al Nasr and Nedra Touj and Waleed Koko and Tariq Khan and İlker Özdemir and Sedat Yaşar and Naceur Hamdi},

title = {Biological Activities of NHC–Pd(II) Complexes Based on Benzimidazolylidene N-heterocyclic Carbene (NHC) Ligands Bearing Aryl Substituents},

journal = {Catalysts},

year = {2020},

volume = {10},

publisher = {MDPI},

month = {oct},

url = {https://doi.org/10.3390/catal10101190},

number = {10},

pages = {1190},

doi = {10.3390/catal10101190}

}

MLA

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MLA Copy

Al Nasr, Ibrahim, et al. “Biological Activities of NHC–Pd(II) Complexes Based on Benzimidazolylidene N-heterocyclic Carbene (NHC) Ligands Bearing Aryl Substituents.” Catalysts, vol. 10, no. 10, Oct. 2020, p. 1190. https://doi.org/10.3390/catal10101190.

Publisher

MDPI

Journal

Catalysts

scimago Q2

wos Q2

SJR

0.746

CiteScore

7.6

Impact factor

4.0

ISSN

20734344 (Print, Electronic)