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Cells

, том 9 , издание 2 , страницы 406

Future Therapeutic Directions for Smac-Mimetics

Emma Morrish ^{1, 2}

Gabriela Brumatti ^{1, 2}

John Silke ^{1, 2}

Скрыть аффилиации авторов Показать аффилиации авторов: 2 аффилиации

Inflammation Division, Walter and Eliza Hall Institute of Medical Research, Melbourne VIC 3052, Australia

Институт медицинских исследований Уолтера и Элизы Холл

Королевская детская больница

Department of Medical Biology, University of Melbourne, Melbourne VIC 3010, Australia |

Тип публикации: Journal Article

Дата публикации: 2020-02-11

MDPI

Cells

scimago Q1

wos Q2

БС1

SJR: 1.670

CiteScore: 10.5

Impact factor: 5.2

ISSN: 20734409

DOI: 10.3390/cells9020406

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PubMed ID: 32053868

General Medicine

Краткое описание

It is well accepted that the ability of cancer cells to circumvent the cell death program that untransformed cells are subject to helps promote tumor growth. Strategies designed to reinstate the cell death program in cancer cells have therefore been investigated for decades. Overexpression of members of the Inhibitor of APoptosis (IAP) protein family is one possible mechanism hindering the death of cancer cells. To promote cell death, drugs that mimic natural IAP antagonists, such as second mitochondria-derived activator of caspases (Smac/DIABLO) were developed. Smac-Mimetics (SMs) have entered clinical trials for hematological and solid cancers, unfortunately with variable and limited results so far. This review explores the use of SMs for the treatment of cancer, their potential to synergize with up-coming treatments and, finally, discusses the challenges and optimism facing this strategy.

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Московский государственный университет имени М.В. Ломоносова

Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН

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Институт органической и физической химии им. А.Е. Арбузова КазНЦ РАН

Казанский национальный исследовательский технологический университет

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Morrish E. et al. Future Therapeutic Directions for Smac-Mimetics // Cells. 2020. Vol. 9. No. 2. p. 406.

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Morrish E., Brumatti G., Silke J. Future Therapeutic Directions for Smac-Mimetics // Cells. 2020. Vol. 9. No. 2. p. 406.

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TY - JOUR

DO - 10.3390/cells9020406

UR - https://doi.org/10.3390/cells9020406

TI - Future Therapeutic Directions for Smac-Mimetics

T2 - Cells

AU - Morrish, Emma

AU - Brumatti, Gabriela

AU - Silke, John

PY - 2020

DA - 2020/02/11

PB - MDPI

SP - 406

IS - 2

VL - 9

PMID - 32053868

SN - 2073-4409

ER -

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@article{2020_Morrish,

author = {Emma Morrish and Gabriela Brumatti and John Silke},

title = {Future Therapeutic Directions for Smac-Mimetics},

journal = {Cells},

year = {2020},

volume = {9},

publisher = {MDPI},

month = {feb},

url = {https://doi.org/10.3390/cells9020406},

number = {2},

pages = {406},

doi = {10.3390/cells9020406}

}

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Morrish, Emma, et al. “Future Therapeutic Directions for Smac-Mimetics.” Cells, vol. 9, no. 2, Feb. 2020, p. 406. https://doi.org/10.3390/cells9020406.

Издатель

MDPI

Журнал

Cells

scimago Q1

wos Q2

БС1

SJR

1.670

CiteScore

10.5

Impact factor

5.2

ISSN

20734409 (Print, Electronic)