Open Access
Current Issues in Molecular Biology, volume 44, issue 5, pages 1950-1959
Palladium Phthalocyanines Varying in Substituents Position for Photodynamic Inactivation of Flavobacterium hydatis as Sensitive and Resistant Species
V. Mantareva
1
,
Vesselin Kussovski
2
,
Petya Orozova
3
,
Ivan Angelov
1
,
Mahmut Durmuş
4
,
Hristo M. Najdenski
2
2
The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
|
3
National Reference Laboratory for Fish, Mollusks and Crustacean Diseases, National Diagnostic Research Veterinary Institute, 1000 Sofia, Bulgaria
|
Publication type: Journal Article
Publication date: 2022-04-29
Journal:
Current Issues in Molecular Biology
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 3.1
ISSN: 14673037, 14673045
Molecular Biology
General Medicine
Microbiology (medical)
Microbiology
Abstract
Antimicrobial photodynamic therapy (aPDT) has been considered as a promising methodology to fight the multidrug resistance of pathogenic bacteria. The procedure involves a photoactive compound (photosensitizer), the red or near infrared spectrum for its activation, and an oxygen environment. In general, reactive oxygen species are toxic to biomolecules which feature a mechanism of photodynamic action. The present study evaluates two clinical isolates of Gram-negative Flavobacteriumhydatis (F. hydatis): a multidrug resistant (R) and a sensitive (S) strain. Both occur in farmed fish, leading to the big production losses because of the inefficacy of antibiotics. Palladium phthalocyanines (PdPcs) with methylpyridiloxy groups linked peripherally (pPdPc) or non-peripherally (nPdPc) were studied with full photodynamic inactivation for 5.0 µM nPdPc toward both F. hydatis, R and S strains (6 log), but with a half of this value (3 log) for 5.0 µM pPdPc and only for F. hydatis, S. In addition to the newly synthesized PdPcs as a “positive control” was applied a well-known highly effective zinc phthalocyanine (ZnPcMe). ZnPcMe showed optimal photocytotoxicity for inactivation of both F. hydatis R and S. The present study is encouraging for a further development of aPDT with phthalocyanines as an alternative method to antibiotic medication to keep under control the harmful pathogens in aquacultures’ farms.
Top-30
Citations by journals
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1
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International Journal of Molecular Sciences
1 publication, 16.67%
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Frontiers in Cellular and Infection Microbiology
1 publication, 16.67%
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Russian Chemical Reviews
1 publication, 16.67%
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Environmental Microbiology Reports
1 publication, 16.67%
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Fishes
1 publication, 16.67%
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Archives of Microbiology
1 publication, 16.67%
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1
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Citations by publishers
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1
2
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 33.33%
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Frontiers Media S.A.
1 publication, 16.67%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 16.67%
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Wiley
1 publication, 16.67%
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Springer Nature
1 publication, 16.67%
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1
2
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Mantareva V. et al. Palladium Phthalocyanines Varying in Substituents Position for Photodynamic Inactivation of Flavobacterium hydatis as Sensitive and Resistant Species // Current Issues in Molecular Biology. 2022. Vol. 44. No. 5. pp. 1950-1959.
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Mantareva V., Kussovski V., Orozova P., Angelov I., Durmuş M., Najdenski H. M. Palladium Phthalocyanines Varying in Substituents Position for Photodynamic Inactivation of Flavobacterium hydatis as Sensitive and Resistant Species // Current Issues in Molecular Biology. 2022. Vol. 44. No. 5. pp. 1950-1959.
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TY - JOUR
DO - 10.3390/cimb44050133
UR - https://doi.org/10.3390/cimb44050133
TI - Palladium Phthalocyanines Varying in Substituents Position for Photodynamic Inactivation of Flavobacterium hydatis as Sensitive and Resistant Species
T2 - Current Issues in Molecular Biology
AU - Kussovski, Vesselin
AU - Orozova, Petya
AU - Angelov, Ivan
AU - Durmuş, Mahmut
AU - Mantareva, V.
AU - Najdenski, Hristo M.
PY - 2022
DA - 2022/04/29 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1950-1959
IS - 5
VL - 44
SN - 1467-3037
SN - 1467-3045
ER -
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@article{2022_Mantareva,
author = {Vesselin Kussovski and Petya Orozova and Ivan Angelov and Mahmut Durmuş and V. Mantareva and Hristo M. Najdenski},
title = {Palladium Phthalocyanines Varying in Substituents Position for Photodynamic Inactivation of Flavobacterium hydatis as Sensitive and Resistant Species},
journal = {Current Issues in Molecular Biology},
year = {2022},
volume = {44},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {apr},
url = {https://doi.org/10.3390/cimb44050133},
number = {5},
pages = {1950--1959},
doi = {10.3390/cimb44050133}
}
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MLA
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Mantareva, V., et al. “Palladium Phthalocyanines Varying in Substituents Position for Photodynamic Inactivation of Flavobacterium hydatis as Sensitive and Resistant Species.” Current Issues in Molecular Biology, vol. 44, no. 5, Apr. 2022, pp. 1950-1959. https://doi.org/10.3390/cimb44050133.