Open Access
Dentistry Journal, volume 10, issue 12, pages 234
Application of the Extracts of Punica granatum in Oral Cancer: Scoping Review
Mario Dioguardi
1
,
Andrea Ballini
2
,
Diego Sovereto
1
,
Francesca Spirito
1
,
Angela Pia Cazzolla
1
,
Riccardo Aiuto
3
,
Vito Crincoli
4
,
Giorgia Apollonia Caloro
5
,
Lo Muzio
1
2
5
Unità Operativa Nefrologia e Dialisi, Presidio Ospedaliero Scorrano, ASL (Azienda Sanitaria Locale) Lecce, Via Giuseppina Delli Ponti, 73020 Scorrano, Italy
|
Publication type: Journal Article
Publication date: 2022-12-09
General Dentistry
Abstract
The Punica granatum L. is an ancient fruit plant native to south-western Asia. It belongs to the Litraceae family and of its genus we have only one other Punica protopunic species. The fruit is rich in polyphenols, whose extract is consumed as a food and is considered safe. In medicine, it is used for its antioxidant properties; it has a rich component of tannic polyphenols among which the most bioactive are: punicalagin (flavonoids) and anthocyanins (delphinidin, cyanidin, pelargonidin), which are found mainly in the skins and in the pericarp; however, all the parts of the Punica granatum are used for therapeutic purposes as anti-inflammatories and analgesics and in diabetes and cardio-vascular disease. Punica granatum extracts also show interesting anticancer activities in influencing tumorgenesis and angiogenesis and cell transformation and proliferation. The purpose of this scoping review is to summarize all the scientific evidence on the possible applications of Punica granatum extracts in the treatment and prevention of oral cavity tumors to investigate the anticancer properties of the active ingredients extracted from Punica granatum. Methods: The scoping review was carried out following the PRISMA-ScR checklist; the search was performed on three databases (Scopus, Science direct and PubMed) and one registry (Cochrane library). Results: The search produced a number of bibliographic sources equal to 11,403; with the removal of duplicates, 670 potentially admissible articles were obtained, from 24 of which only 7 in vitro studies on OSCC cell lines were included. Conclusions: From the preliminary data on the cellular lines of OSCC, it emerges that for oral cancer there are conditions for which the extracts of Punic granatum are effective at least from a prevention perspective.
Top-30
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Citations by publishers
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Wiley
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Dioguardi M. et al. Application of the Extracts of Punica granatum in Oral Cancer: Scoping Review // Dentistry Journal. 2022. Vol. 10. No. 12. p. 234.
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Dioguardi M., Ballini A., Sovereto D., Spirito F., Cazzolla A. P., Aiuto R., Crincoli V., Caloro G. A., Muzio L. Application of the Extracts of Punica granatum in Oral Cancer: Scoping Review // Dentistry Journal. 2022. Vol. 10. No. 12. p. 234.
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TY - JOUR
DO - 10.3390/dj10120234
UR - https://doi.org/10.3390/dj10120234
TI - Application of the Extracts of Punica granatum in Oral Cancer: Scoping Review
T2 - Dentistry Journal
AU - Dioguardi, Mario
AU - Ballini, Andrea
AU - Sovereto, Diego
AU - Spirito, Francesca
AU - Cazzolla, Angela Pia
AU - Aiuto, Riccardo
AU - Crincoli, Vito
AU - Caloro, Giorgia Apollonia
AU - Muzio, Lo
PY - 2022
DA - 2022/12/09 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 234
IS - 12
VL - 10
SN - 2304-6767
ER -
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@article{2022_Dioguardi,
author = {Mario Dioguardi and Andrea Ballini and Diego Sovereto and Francesca Spirito and Angela Pia Cazzolla and Riccardo Aiuto and Vito Crincoli and Giorgia Apollonia Caloro and Lo Muzio},
title = {Application of the Extracts of Punica granatum in Oral Cancer: Scoping Review},
journal = {Dentistry Journal},
year = {2022},
volume = {10},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {dec},
url = {https://doi.org/10.3390/dj10120234},
number = {12},
pages = {234},
doi = {10.3390/dj10120234}
}
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Dioguardi, Mario, et al. “Application of the Extracts of Punica granatum in Oral Cancer: Scoping Review.” Dentistry Journal, vol. 10, no. 12, Dec. 2022, p. 234. https://doi.org/10.3390/dj10120234.