Open Access
Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects
Publication type: Journal Article
Publication date: 2020-06-25
scimago Q1
wos Q1
SJR: 1.273
CiteScore: 9.0
Impact factor: 4.9
ISSN: 16616596, 14220067
PubMed ID:
32630547
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
Aptamers are short single stranded DNA or RNA oligonucleotides that can recognize analytes with extraordinary target selectivity and affinity. Despite their promising properties and diagnostic potential, the number of commercial applications remains scarce. In order to endow them with novel recognition motifs and enhanced properties, chemical modification of aptamers has been pursued. This review focuses on chemical modifications, aimed at increasing the binding affinity for the aptamer’s target either in a non-covalent or covalent fashion, hereby improving their application potential in a diagnostic context. An overview of current methodologies will be given, thereby distinguishing between pre- and post-SELEX (Systematic Evolution of Ligands by Exponential Enrichment) modifications.
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135
Total citations:
135
Citations from 2024:
60
(44.44%)
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GOST
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Elskens J. P., Elskens J. M., Madder A. Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects // International Journal of Molecular Sciences. 2020. Vol. 21. No. 12. p. 4522.
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Elskens J. P., Elskens J. M., Madder A. Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects // International Journal of Molecular Sciences. 2020. Vol. 21. No. 12. p. 4522.
Cite this
RIS
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TY - JOUR
DO - 10.3390/ijms21124522
UR - https://doi.org/10.3390/ijms21124522
TI - Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects
T2 - International Journal of Molecular Sciences
AU - Elskens, Jan P
AU - Elskens, Joke M
AU - Madder, Annemieke
PY - 2020
DA - 2020/06/25
PB - MDPI
SP - 4522
IS - 12
VL - 21
PMID - 32630547
SN - 1661-6596
SN - 1422-0067
ER -
Cite this
BibTex (up to 50 authors)
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@article{2020_Elskens,
author = {Jan P Elskens and Joke M Elskens and Annemieke Madder},
title = {Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects},
journal = {International Journal of Molecular Sciences},
year = {2020},
volume = {21},
publisher = {MDPI},
month = {jun},
url = {https://doi.org/10.3390/ijms21124522},
number = {12},
pages = {4522},
doi = {10.3390/ijms21124522}
}
Cite this
MLA
Copy
Elskens, Jan P., et al. “Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects.” International Journal of Molecular Sciences, vol. 21, no. 12, Jun. 2020, p. 4522. https://doi.org/10.3390/ijms21124522.