Open Access
Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects
Тип публикации: Journal Article
Дата публикации: 2020-06-25
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 1.316
CiteScore: 9
Impact factor: 4.9
ISSN: 16616596, 14220067
PubMed ID:
32630547
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Краткое описание
Aptamers are short single stranded DNA or RNA oligonucleotides that can recognize analytes with extraordinary target selectivity and affinity. Despite their promising properties and diagnostic potential, the number of commercial applications remains scarce. In order to endow them with novel recognition motifs and enhanced properties, chemical modification of aptamers has been pursued. This review focuses on chemical modifications, aimed at increasing the binding affinity for the aptamer’s target either in a non-covalent or covalent fashion, hereby improving their application potential in a diagnostic context. An overview of current methodologies will be given, thereby distinguishing between pre- and post-SELEX (Systematic Evolution of Ligands by Exponential Enrichment) modifications.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Для доступа к списку цитирований публикации необходимо авторизоваться.
Для доступа к списку профилей, цитирующих публикацию, необходимо авторизоваться.
Топ-30
Журналы
|
1
2
3
4
5
|
|
|
International Journal of Molecular Sciences
5 публикаций, 3.5%
|
|
|
ChemBioChem
4 публикации, 2.8%
|
|
|
Biomedicines
3 публикации, 2.1%
|
|
|
Molecules
3 публикации, 2.1%
|
|
|
Molecular Therapy - Nucleic Acids
3 публикации, 2.1%
|
|
|
Chemical Science
3 публикации, 2.1%
|
|
|
Microchemical Journal
3 публикации, 2.1%
|
|
|
Sensors
2 публикации, 1.4%
|
|
|
Biotechnology Advances
2 публикации, 1.4%
|
|
|
Trends in Biotechnology
2 публикации, 1.4%
|
|
|
Journal of Physical Chemistry B
2 публикации, 1.4%
|
|
|
Exploration of Medicine
2 публикации, 1.4%
|
|
|
ACS Sensors
2 публикации, 1.4%
|
|
|
Biosensors
2 публикации, 1.4%
|
|
|
Journal of Biomolecular Structure and Dynamics
2 публикации, 1.4%
|
|
|
Analytica Chimica Acta
2 публикации, 1.4%
|
|
|
Angewandte Chemie - International Edition
2 публикации, 1.4%
|
|
|
Angewandte Chemie
2 публикации, 1.4%
|
|
|
Journal of Drug Targeting
2 публикации, 1.4%
|
|
|
Journal of Agricultural and Food Chemistry
2 публикации, 1.4%
|
|
|
Microchimica Acta
2 публикации, 1.4%
|
|
|
Analytical Chemistry
1 публикация, 0.7%
|
|
|
Current Pharmaceutical Design
1 публикация, 0.7%
|
|
|
Tropical Medicine and Infectious Disease
1 публикация, 0.7%
|
|
|
Processes
1 публикация, 0.7%
|
|
|
Biophysica
1 публикация, 0.7%
|
|
|
Coatings
1 публикация, 0.7%
|
|
|
Science China Chemistry
1 публикация, 0.7%
|
|
|
World Journal of Microbiology and Biotechnology
1 публикация, 0.7%
|
|
|
1
2
3
4
5
|
Издатели
|
5
10
15
20
25
30
35
40
45
|
|
|
Elsevier
44 публикации, 30.77%
|
|
|
MDPI
22 публикации, 15.38%
|
|
|
Wiley
17 публикаций, 11.89%
|
|
|
American Chemical Society (ACS)
13 публикаций, 9.09%
|
|
|
Springer Nature
13 публикаций, 9.09%
|
|
|
Royal Society of Chemistry (RSC)
10 публикаций, 6.99%
|
|
|
Taylor & Francis
5 публикаций, 3.5%
|
|
|
Bentham Science Publishers Ltd.
3 публикации, 2.1%
|
|
|
Open Exploration Publishing
3 публикации, 2.1%
|
|
|
Public Library of Science (PLoS)
2 публикации, 1.4%
|
|
|
openRxiv
1 публикация, 0.7%
|
|
|
IntechOpen
1 публикация, 0.7%
|
|
|
AIP Publishing
1 публикация, 0.7%
|
|
|
The Electrochemical Society
1 публикация, 0.7%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 публикация, 0.7%
|
|
|
Mary Ann Liebert
1 публикация, 0.7%
|
|
|
Oxford University Press
1 публикация, 0.7%
|
|
|
Ovid Technologies (Wolters Kluwer Health)
1 публикация, 0.7%
|
|
|
Frontiers Media S.A.
1 публикация, 0.7%
|
|
|
Ural Federal University
1 публикация, 0.7%
|
|
|
5
10
15
20
25
30
35
40
45
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.
Вы ученый?
Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Войти с ORCID
Метрики
143
Всего цитирований:
143
Цитирований c 2025:
36
(25.17%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Elskens J. P., Elskens J. M., Madder A. Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects // International Journal of Molecular Sciences. 2020. Vol. 21. No. 12. p. 4522.
ГОСТ со всеми авторами (до 50)
Скопировать
Elskens J. P., Elskens J. M., Madder A. Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects // International Journal of Molecular Sciences. 2020. Vol. 21. No. 12. p. 4522.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.3390/ijms21124522
UR - https://doi.org/10.3390/ijms21124522
TI - Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects
T2 - International Journal of Molecular Sciences
AU - Elskens, Jan P
AU - Elskens, Joke M
AU - Madder, Annemieke
PY - 2020
DA - 2020/06/25
PB - MDPI
SP - 4522
IS - 12
VL - 21
PMID - 32630547
SN - 1661-6596
SN - 1422-0067
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2020_Elskens,
author = {Jan P Elskens and Joke M Elskens and Annemieke Madder},
title = {Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects},
journal = {International Journal of Molecular Sciences},
year = {2020},
volume = {21},
publisher = {MDPI},
month = {jun},
url = {https://doi.org/10.3390/ijms21124522},
number = {12},
pages = {4522},
doi = {10.3390/ijms21124522}
}
Цитировать
MLA
Скопировать
Elskens, Jan P., et al. “Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects.” International Journal of Molecular Sciences, vol. 21, no. 12, Jun. 2020, p. 4522. https://doi.org/10.3390/ijms21124522.
Ошибка в публикации?